Article
Oncology
Lian Chen, Jinpeng Zhou, Long Li, Junshuang Zhao, Hao Li, Wei Zheng, Jinkun Xu, Zhitao Jing
Summary: SLC39A7 promotes the malignant behaviors of glioma cells by activating the TNF-alpha-mediated NF-kappa B signaling pathway, providing potential targets for glioma therapy.
Article
Biochemistry & Molecular Biology
Li-Ping Lin, Tung-Yang Yu, Hsiang-Ning Chang, Wen-Chung Tsai, Jong-Hwei S. Pang
Summary: Statins, particularly simvastatin, have been found to inhibit the proliferation and migration of skeletal muscle cells by affecting the rearrangement of the cytoskeleton. This inhibition is attributed to the reduced expressions of cofilin and stathmin, which are crucial for cell migration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Mathilde Kerherve, Sara Rosinska, Kilian Trillet, Alya Zeinaty, Magalie Feyeux, Steven Nedellec, Julie Gavard
Summary: Glioblastoma multiforme (GBM) is a rare but devastating brain tumor in adults, with current treatments being generally ineffective. This study focused on a population of self-sustaining transformed cells with stem-like properties (GSCs) within GBM, which play a crucial role in tumor initiation, growth, invasion, and recurrence. An ex vivo model was established to explore the invasive behavior of GSCs, and it was found that the glycoprotein Neuropilin-1 (NRP1) contributes to their spreading and invasion. This study proposes a reliable approach to studying invasive properties of patient glioma cells and identifies NRP1 as a mediator in this malignant process.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Yan Wang, Yu Zhang, Ben Sang, Xianlong Zhu, Rutong Yu, Xiuping Zhou
Summary: Hugl-1 promotes migration and invasion of malignant glioma cells by decreasing N-cadherin expression while inhibiting cell proliferation. It may serve a dual biological role in cellular processes, and could be applied in targeted and personalized treatment development.
Article
Pharmacology & Pharmacy
Jingwen Yuan, Shahid Ullah Khan, Jiajun Luo, Yue Jiang, Yu Yang, Junfeng Yan, Qiang Tong
Summary: Biosynthetic silver nanoparticles (b-Ag) exhibit strong cytotoxic effects on gastric cancer (GC) and enhance the inhibitory effect of 5-fluorouracil (5F) on GC by promoting cell apoptosis and increasing intracellular ROS generation.
Article
Pharmacology & Pharmacy
Ruiyan Cen, Liqun Wang, Yongqing He, Chenda Yue, Yang Tan, Lingfei Li, Xia Lei
Summary: This study reveals an important role of stathmin in the migration and proliferation of dermal fibroblasts. Stathmin is shown to increase with p38/MAPK pathway activation in response to lipopolysaccharide stimulation, resulting in microtubule depolymerization and increased migration and proliferation of dermal fibroblasts. Targeting stathmin or the p38/MAPK pathway could be a potential strategy for clinical interventions in wound healing.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Qiuyu Chen, Lingyun Zhang, Changshan Wan, Boli Yang, Xiangxu Kong, Xin Xu, Yu Gu, Chen Wang, Xiaotong Liu, Qian Ding, Lanping Zhu, Ying Li, Bangmao Wang, Weilong Zhong
Summary: The aim of this study was to investigate the role of transgelin (TAGLN) in the ferroptosis of esophageal squamous cell carcinoma (ESCC). TAGLN expression was negatively associated with ESCC prognosis. TAGLN overexpression inhibited the migration, invasion, viability, and proliferation of ESCC cells. TAGLN also promoted ferroptosis in ESCC by interacting with p53. These findings suggest that TAGLN may inhibit the malignant development of ESCC through the induction of ferroptosis.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Qiuyun Yuan, Wanchun Yang, Shuxin Zhang, Tengfei Li, Mingrong Zuo, Xingwang Zhou, Junhong Li, Mao Li, Xiaoqiang Xia, Mina Chen, Yanhui Liu
Summary: The study revealed a close association between MTCH2 expression and glioma malignancy, as well as poor patient survival. Silencing MTCH2 expression weakened cell migration/invasion abilities and increased sensitivity to temozolomide, possibly through regulating mitochondrial oxidative damage and repressing AKT signaling.
MOLECULAR MEDICINE
(2021)
Article
Oncology
Xiangdong Xu, Yang Liu, Yan Li, Huajian Chen, Yuxuan Zhang, Jie Liu, Shaokang Deng, Yaofeng Zheng, Xinlin Sun, Jihui Wang, Taoliang Chen, Min Huang, Yiquan Ke
Summary: MiR-375 expression is downregulated in gliomas, and it suppresses glioma proliferation, migration, and invasion by inhibiting the CTGF-EGFR signaling pathway. MiR-375-containing exosomes were found in human blood samples from glioma patients, with levels correlating with disease progression. Exosomal miR-375 secretion impacts the activity of the CTGF-EGFR pathway, and once secreted, exosomal miR-375 is not taken back up by glioma cells.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Review
Oncology
Shihong Lv, Zhiye Chen, Hailong Mi, Xingjiang Yu
Summary: Cofilin plays a crucial role in actin structural reorganization and dynamic regulation. It has the potential to serve as a biomarker for predicting tumor metastasis and prognosis in malignant tumors. Targeting cofilin regulating kinases and the cofilin-mediated mitochondrial pathway could be effective options for the development of novel anti-malignant tumor drugs.
CANCER MANAGEMENT AND RESEARCH
(2022)
Article
Cell Biology
Xiaosong Wang, Xiaojun Yu, Haoran Xu, Kang Wei, Shanxi Wang, Yingguang Wang, Junfei Han
Summary: In this study, the researchers found that extracellular vesicles (EVs) transfer a long non-coding RNA (lncRNA) called HOTAIR, which regulates resistance to the chemotherapy drug temozolomide (TMZ) in glioblastoma (GBM). Through in vitro and in vivo experiments, it was demonstrated that HOTAIR promotes tumor growth, increases invasiveness, and enhances resistance to TMZ. In GBM cells, HOTAIR competitively binds to miR-526b-3p, weakening its ability to bind to EVA1 and consequently increasing EVA1 expression. Furthermore, HOTAIR carried by serum-EVs suppresses miR-526b-3p-mediated inhibition of EVA1, promoting tumor growth and TMZ resistance in vivo.
CELL DEATH & DISEASE
(2022)
Article
Immunology
Sen Zhang, Huangfu Hui, Qinli Zhao, Yujun Li, Lina Wu
Summary: This study revealed that the long noncoding RNA HCP5 is highly expressed in laryngeal squamous cell carcinoma (LSCC) and plays a role in promoting cancer cell growth, migration, and invasion. HCP5 interacts with miR-216a-5p, and its knockdown inhibits the malignant biological function of LSCC cells. Moreover, miR-216a-5p downregulates the expression of ZEB1, a target gene involved in LSCC progression. These findings suggest that targeting HCP5 may be a potential therapeutic strategy for LSCC.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biology
Qiang Wu, Ling Liu, Yan Feng, Liqun Wang, Xin Liu, Yanan Li
Summary: This study found that UBR5 is highly expressed in human glioma and promotes the migration and invasion of glioma cells by regulating the ECRG4/NF-kappa B pathway.
JOURNAL OF BIOSCIENCES
(2022)
Article
Oncology
Yue Xiao, Wenjing Ma, Weiwei Hu, Qianqian Di, Xibao Zhao, Xingyu Ma, Xinyi Chen, Ping Sun, Han Wu, Zherui Wu, Weilin Chen
Summary: USP39 induces the expression of ADAM9 in glioma cells, promoting cell invasion and migration, and reducing overall survival in patients with glioma.
MOLECULAR ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Jialin Wang, Zhendong Liu, Cheng Zhang, Hongbo Wang, Ang Li, Binfeng Liu, Xiaoyu Lian, Zhishuai Ren, Wang Zhang, Yanbiao Wang, Bo Zhang, Bo Pang, Yanzheng Gao
Summary: High expression of HOXD11 is significantly associated with survival and clinical characteristics of glioma patients, serving as a potential biomarker for targeted therapy and prognostic assessment. Knockout of HOXD11 can inhibit proliferation and invasion of glioma cells, altering cell behavior.
Article
Chemistry, Applied
Fei-Hua Yao, Xiao Liang, Shu-Hua Qi
Summary: By altering culture medium compositions, the OSMAC strategy was used to isolate new cyclopentenone and cyclohexenone derivatives from a fungal strain, with structures elucidated and absolute configurations confirmed for specific compounds through extensive spectroscopic analysis and single-crystal X-ray diffraction experiments.
NATURAL PRODUCT RESEARCH
(2021)
Review
Chemistry, Multidisciplinary
Carlos Sanchez-Cano, Ramon A. Alvarez-Puebla, John M. Abendroth, Tobias Beck, Robert Blick, Yuan Cao, Frank Caruso, Indranath Chakraborty, Henry N. Chapman, Chunying Chen, Bruce E. Cohen, Andre L. C. Conceicao, David P. Cormode, Daxiang Cui, Kenneth A. Dawson, Gerald Falkenberg, Chunhai Fan, Neus Feliu, Mingyuan Gao, Elisabetta Gargioni, Claus-C Glueer, Florian Gruener, Moustapha Hassan, Yong Hu, Yalan Huang, Samuel Huber, Nils Huse, Yanan Kang, Ali Khademhosseini, Thomas F. Keller, Christian Koernig, Nicholas A. Kotov, Dorota Koziej, Xing-Jie Liang, Beibei Liu, Sijin Liu, Yang Liu, Ziyao Liu, Luis M. Liz-Marzan, Xiaowei Ma, Andres Machicote, Wolfgang Maison, Adrian P. Mancuso, Saad Megahed, Bert Nickel, Ferdinand Otto, Cristina Palencia, Sakura Pascarelli, Arwen Pearson, Oula Penate-Medina, Bing Qi, Joachim Raedler, Joseph J. Richardson, Axel Rosenhahn, Kai Rothkamm, Michael Rubhausen, Milan K. Sanyal, Raymond E. Schaak, Heinz-Peter Schlemmer, Marius Schmidt, Oliver Schmutzler, Theo Schotten, Florian Schulz, A. K. Sood, Kathryn M. Spiers, Theresa Staufer, Dominik M. Stemer, Andreas Stierle, Xing Sun, Gohar Tsakanova, Paul S. Weiss, Horst Weller, Fabian Westermeier, Ming Xu, Huijie Yan, Yuan Zeng, Ying Zhao, Yuliang Zhao, Dingcheng Zhu, Ying Zhu, Wolfgang J. Parak
Summary: X-ray-based analytics are widely used in physics, chemistry, materials science, and engineering, but their full potential in life sciences and medicine has not been fully utilized. Current and upcoming advances in applying these techniques to investigate the nano-bio interface are discussed, along with addressing current limitations and potential strategies for future in vivo use.
Article
Chemistry, Multidisciplinary
Hong-Bo Cheng, Bin Qiao, Hao Li, Jin Cao, Yuanli Luo, Kunemadihalli Mathada Kotraiah Swamy, Jing Zhao, Zhigang Wang, Jin Yong Lee, Xing-Jie Liang, Juyoung Yoon
Summary: This study developed a novel reversible photodynamic therapy switch for controlling the production of singlet oxygen, providing a potential strategy for photodynamic-immunotherapy.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Multidisciplinary
Chunhui Li, Junhui Zhou, Yidi Wu, Yanliang Dong, Lili Du, Tongren Yang, Yongheng Wang, Shuai Guo, Mengjie Zhang, Abid Hussain, Haihua Xiao, Yuhua Weng, Yong Huang, Xiaoxia Wang, Zicai Liang, Huiqing Cao, Yongxiang Zhao, Xing-Jie Liang, Anjie Dong, Yuanyu Huang
Summary: The study synthesized a series of quaternary ammonium-based amphiphilic triblock polymers with a pH-sensitive hydrophobic core that can rapidly release internalized siRNA in endosomal pH environment, leading to enhanced gene silencing activity and significant therapeutic effects in tumor models.
Article
Chemistry, Multidisciplinary
Tongren Yang, Dong Huang, Chunhui Li, Deyao Zhao, Junshi Li, Mengjie Zhang, Yufeng Chen, Qining Wang, Zicai Liang, Xing-Jie Liang, Zhihong Li, Yuanyu Huang
Summary: Topical administration of siRNA is a promising therapeutic modality, and RoMEA, an engineered rolling microneedle electrode array, enables efficient and extensive siRNA therapy. The use of RoMEA leads to effective siRNA delivery and gene silencing.
Review
Chemistry, Multidisciplinary
Hong-Bo Cheng, Shuchun Zhang, Ji Qi, Xing-Jie Liang, Juyoung Yoon
Summary: Azobenzene, a well-known derivative of stimulus-responsive molecular switches, has shown superior performance in biomedical applications. Recent studies have focused on developing long-wavelength-responsive azobenzene, matching its characteristics to the bio-optical window for larger and more effective stimulus response. The use of azobenzene as a hypoxia-sensitive connector has also resulted in on/off state switching of properties such as pharmacology and fluorescence activity. Here, we summarize recent advances in utilizing azobenzene as a trigger in biomedicine.
ADVANCED MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Xiaoli Liu, Yifan Zhang, Yu Guo, Wangbo Jiao, Xiao Gao, Wee Siang Vincent Lee, Yanyun Wang, Xia Deng, Yuan He, Ju Jiao, Ce Zhang, Guoqing Hu, Xing-Jie Liang, Haiming Fan
Summary: A strategy is described to induce a succession of magnetoresponses in magnetic nanovehicles by employing sequential EF frequencies, aiming to achieve cascaded tissue penetration and nuclear accumulation. Programming the order of low frequency and medium frequency EF operations enables effective delivery of 86.2% drug into the nucleus by DOX-PI/FVIOs.
Article
Chemistry, Analytical
Tiantian Si, Shuai Wang, Haixia Zhang, Xiaofeng Lu, Licheng Wang, Xiaojing Liang, Yong Guo
Summary: The preparation of metal-organic frameworks@silica core-shell microspheres as stationary phases relies on electrostatic interaction between metal ions of MOFs and silanol groups. By modifying MOFs ligands to silica surface, the evenness of MOFs particles on silica surface is improved, resulting in composites with excellent reproducibility and stability. The obtained composites show enhanced separation selectivity for various compounds, including alkaloids, nucleosides, antibiotics, and alkylbenzenes, demonstrating superior reproducibility, stability, and satisfactory separation performance.
ANALYTICA CHIMICA ACTA
(2021)
Article
Engineering, Environmental
Xianlei Li, Zi'an Pan, Chenyang Xiang, Yuan Yuan, Jing Chen, Guangchao Qing, Jing Ma, Xing-Jie Liang, Yan Wu, Weisheng Guo
Summary: Researchers have developed transformable CuS@GNPs nanoparticles that can undergo enzyme-induced multistage delivery, leading to enhanced accumulation at the tumor site and deeper penetration.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Dentistry, Oral Surgery & Medicine
Congna Chai, Lei Cheng, Jianjun Jiao, Juan Dang, Shubin Jin
Summary: This study identified potential risk factors for non-syndromic cleft lip with or without palate (NSCL/P) in rural districts, including maternal periconceptional exposure to pesticides and herbicides, low parental education level, as well as maternal folic acid and multivitamin supplementation use during the preconception period. In addition, genetic risk factors associated with NSCL/P were also identified.
CLEFT PALATE CRANIOFACIAL JOURNAL
(2023)
Article
Chemistry, Analytical
Fangbin Fan, Xiaofeng Lu, Shuai Wang, Licheng Wang, Xiaojing Liang, Yong Guo
Summary: By introducing functional groups, the hydrogel composite-modified silica showed improved separation effects and can be used for selective separation of various analytes. The new stationary phase exhibited excellent performance, with low relative standard deviations and high efficiency in liquid chromatography separation.
Review
Nanoscience & Nanotechnology
Hong Tan, Mengyu Zhang, Yuqing Wang, Peter Timashev, Yuanyuan Zhang, Shouwen Zhang, Xing-Jie Liang, Fangzhou Li
Summary: Tumor multidrug resistance is a major cause of clinical chemotherapy failure, and nanotechnology offers various strategies to overcome this issue. Further research is needed to explore the mechanisms of drug endocytosis and fate.
Article
Engineering, Biomedical
Meirong Li, Zheng-Ian Lin, Jingyu Yang, Haoqiang Huang, Guan-Lin Liu, Qiqi Liu, Xinmeng Zhang, Ying Zhang, Zhourui Xu, Haoming Lin, Yujuan Chai, Xin Chen, Bao-Tsan Ko, Jia Liu, Chih-Kuang Chen, Chengbin Yang
Summary: Osteosarcoma is a highly invasive and deadly cancer that often occurs in children and adolescents. The overexpression of PLK1 gene in tumors promotes cancer cell proliferation and transformation, making it a therapeutic target for osteosarcoma. However, current RNA interference-based therapies lack a safe and efficient nonviral gene vector. In this study, biodegradable and CO2-derivative cationic poly(vinylcyclohexene carbonates) (CPCHCs) were used as gene vectors for siPLK1 therapeutic strategy in osteosarcoma treatment. Among them, CPCHC60 showed excellent performance in gene transfection efficiency, endo-lysosome escaping, biodegradability, and biosafety. The treatment with CPCHCs/siRNA nanoparticles significantly down-regulated the expression level of PLK1 gene in osteosarcoma cells, leading to cell arrest and apoptosis, resulting in significant tumor regression both in vitro and in vivo. This study provides new insights into the development of superior nonviral gene vectors for cancer treatment and holds high potential for translational nanomedicine applications.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Analytical
Fangbin Fan, Licheng Wang, Xiaofeng Lu, Xiaojing Liang, Yong Guo
Summary: Inspired by porous smart gel materials, researchers designed pH-responsive polymer-modified silica microspheres for use as liquid chromatography stationary phase materials. The hydrophilicity of the stationary phase can change in response to the pH of the mobile phase, leading to differences in separation selectivity. This study provides guidance for achieving more pH-responsive hydrophilic/hydrophobic stationary phases in the future.
Article
Biochemistry & Molecular Biology
Ren Yang, Yao Deng, Baoying Huang, Lei Huang, Ang Lin, Yuhua Li, Wenling Wang, Jingjing Liu, Shuaiyao Lu, Zhenzhen Zhan, Yufei Wang, A. Ruhan, Wen Wang, Peihua Niu, Li Zhao, Shiqiang Li, Xiaopin Ma, Luyao Zhang, Yujian Zhang, Weiguo Yao, Xingjie Liang, Jincun Zhao, Zhongmin Liu, Xiaozhong Peng, Hangwen Li, Wenjie Tan
Summary: SW0123 is a highly efficacious mRNA vaccine candidate with strong immunogenicity, inducing T cell and antibody responses, capable of neutralizing multiple variants, and providing effective protection in animal challenge experiments.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)