Review
Endocrinology & Metabolism
Aleck Hercbergs, Hung-Yun Lin, Shaker A. Mousa, Paul J. Davis
Summary: Thyroid hormone acts on cancer cells through its receptor on the cell surface to promote cell proliferation. It can promote the growth of estrogen receptor-positive breast cancer cells in the absence of estrogen. Additionally, it may contribute to aggressive breast cancer behavior by stimulating immune checkpoint inhibitor gene expression and anti-apoptosis mechanisms.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Stephen Halada, Victoria Casado-Medrano, Julia A. Baran, Joshua Lee, Poojita Chinmay, Andrew J. Bauer, Aime T. Franco
Summary: Differentiated thyroid cancer and breast cancer, predominantly affecting women, share hormonal connections. The breast is responsive to thyroid hormone signaling and the thyroid is responsive to estrogen, leading to cancer progression. Obesity-related adipocyte alterations and environmental toxicants also contribute to hormonal changes in both breast and thyroid tissues. Further research on hormonal crosstalk is necessary to understand and develop potential therapeutic options for these cancers.
Article
Medicine, General & Internal
Annelie Johansson, Athanasia E. Christakou, Adina Iftimi, Mikael Eriksson, Jose Tapia, Lambert Skoog, Christopher C. Benz, Kenny A. Rodriguez-Wallberg, Per Hall, Kamila Czene, Linda S. Lindstrom
Summary: The study found that the risk of benign breast diseases varies by age, hormonal factors, and family history of breast cancer. Factors such as nulliparity, oral contraceptive use, hormone replacement therapy, obesity, and family history were associated with different risks of various breast disease subtypes, highlighting the importance of understanding benign breast diseases for breast cancer prevention.
Review
Endocrinology & Metabolism
Mingyue Han, Yao Wang, Yuanhui Jin, Xue Zhao, Haiying Cui, Guixia Wang, Xiaokun Gang
Summary: This study suggests a correlation between autoimmune thyroiditis, goiter, and Graves' disease and an increased risk of breast cancer. However, hypothyroidism and hyperthyroidism were not significantly associated with the risk of breast cancer. Benign thyroid disease may increase the aggressiveness of breast cancer in the European population.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Respiratory System
Marina Dehara, Michael C. Sachs, Susanna Kullberg, Johan Grunewald, Anders Blomberg, Elizabeth Arkema
Summary: The study found that higher sarcoidosis risk was associated with older age at menarche, natural menopause, later age at first pregnancy, and ever hormone replacement therapy (HRT) use. Lower risk was associated with older age at menopause, longer duration of oral contraceptive use, longer duration of HRT use, ever local estrogen therapy (LET) use, and longer duration of LET use. However, the study indicated that it is still unclear whether longer estrogen exposure is associated with reduced sarcoidosis risk due to inconsistency and modest magnitude in the estimates, as well as the wide credible intervals.
BMC PULMONARY MEDICINE
(2022)
Review
Oncology
Luz Angela de la Roche, Angelica Acevedo-Mesa, Ingrid Lizeth Lizarazo, Rajesh Devassy, Sven Becker, Harald Krentel, Rudy Leon De Wilde
Summary: This study aims to summarize evidence from observational studies on the association between lifetime use of hormonal contraceptives and the risk of breast cancer in women of reproductive age. The meta-analysis of 22 studies suggests that there is a significantly higher risk of developing breast cancer in ever users of hormonal contraceptives. However, the high heterogeneity among studies and publication biases should be taken into consideration when interpreting the results.
Article
Public, Environmental & Occupational Health
Meng Wang, Wei-Wei Gong, Qing-Fang He, Ru-Ying Hu, Min Yu
Summary: The study found that women with later age at first pregnancy and longer duration of breastfeeding had a lower risk of thyroid cancer, supporting the role of reproductive factors in thyroid cancer risk.
Article
Oncology
Lusine Yaghjyan, Rebecca J. Austin-Datta, Hannah Oh, Yujing J. Heng, Adithya D. Vellal, Korsuk Sirinukunwattana, Gabrielle M. Baker, Laura C. Collins, Divya Murthy, Bernard Rosner, Rulla M. Tamimi
Summary: Our study found that nulliparous and women with fewer children tend to have a smaller proportion of epithelium and a greater proportion of stroma in benign breast biopsy samples. Additionally, breastfeeding for >=24 months was associated with a reduced proportion of fat. Older age at first birth in premenopausal women was also linked to specific changes in tissue proportions.
BREAST CANCER RESEARCH
(2021)
Article
Oncology
Sushmita Katuwal, Juha Tapanainen, Eero Pukkala
Summary: This case-control study found that occupational status, occupational physical activity, reproductive history, and postmenopausal hormonal therapy are associated with the risk of breast cancer. White-collar workers had a significantly higher risk of ductal and lobular breast cancer, while moderate occupational physical activity reduced the risk of lobular breast cancer. There was a temporary increase in breast cancer risk after each birth, followed by a long-term protective effect. Continuous estrogen-progestin therapy significantly increased the risk of both ductal and lobular breast cancer, and the use of estradiol plus levonorgestrel intrauterine system devices was also associated with higher risk.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Marta Roman, Javier Louro, Margarita Posso, Rodrigo Alcantara, Lupe Penalva, Maria Sala, Javier del Riego, Miguel Prieto, Carmen Vidal, Mar Sanchez, Xavier Bargallo, Ignasi Tusquets, Xavier Castells
Summary: The study shows that breast density and benign breast disease have independent effects on the risk of breast cancer, with women with benign breast disease and extremely dense breasts having a significantly higher risk of developing breast cancer.
EUROPEAN RADIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Elise A. Lucotte, Yazdan Asgari, Pierre-Emmanuel Sugier, Mojgan Karimi, Cloe Domenighetti, Fabienne Lesueur, Anne Boland-Auge, Evgenia Ostroumova, Florent de Vathaire, Monia Zidane, Pascal Guenel, Jean-Francois Deleuze, Marie-Christine Boutron-Ruault, Gianluca Severi, Benoit Liquet, Therese Truong
Summary: The study reveals a positive genetic correlation between breast cancer and thyroxine levels, as well as a negative genetic correlation between breast cancer and thyroid-stimulating hormone levels. Polygenic risk scores for FT4 and hyperthyroidism are positively associated with breast cancer risk, while the PRS for TSH is inversely associated with breast cancer risk. The research also identifies shared genetic risk factors between breast cancer and thyroid traits.
HUMAN MOLECULAR GENETICS
(2023)
Article
Obstetrics & Gynecology
Lucy Richards, Martin Healey, Claudia Cheng, Charlotte Reddington, Caitlin Robson-Hamond, Uri Dior
Summary: The study identified risk factors for conversion from gynecologic laparoscopy to open surgery, including previous history of pelvic inflammatory disease, open surgery, endometriosis, and elevated body mass index. Conversion to laparotomy was associated with higher rates of intraoperative and post-operative complications and prolonged length of stay.
JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY
(2021)
Article
Multidisciplinary Sciences
Larry Onyango Akoko, Amonius K. Rutashobya, Evelyne W. Lutainulwa, Ally H. Mwanga, Sokoine L. Kivuyo
Summary: This study aimed to determine the factors affecting the development of breast cancer among Tanzanian black women. It found that older age at menopause is a significant risk factor for breast cancer development.
Article
Medicine, General & Internal
Ryoko Katagiri, Motoki Iwasaki, Sarah Krull Abe, Md. Rashedul Islam, Md. Shafiur Rahman, Eiko Saito, Melissa A. Merritt, Ji-Yeob Choi, Aesun Shin, Norie Sawada, Akiko Tamakoshi, Woon-Puay Koh, Ritsu Sakata, Ichiro Tsuji, Jeongseon Kim, Chisato Nagata, Sue K. Park, Sun-Seog Kweon, Xiao-Ou Shu, Yu-Tang Gao, Shoichiro Tsugane, Takashi Kimura, Jian-Min Yuan, Seiki Kanemura, Yukai Lu, Yumi Sugawara, Keiko Wada, Min-Ho Shin, Habibul Ahsan, Paolo Boffetta, Kee Seng Chia, Keitaro Matsuo, You-Lin Qiao, Nathaniel Rothman, Wei Zheng, Manami Inoue, Daehee Kang
Summary: This study found that late menarche, early menopause, and a higher number of deliveries were significantly associated with a lower risk of endometrial cancer. These findings from a large pooled study of Asian women add to the growing body of evidence on the association between reproductive factors and endometrial cancer risk.
Article
Oncology
Ji Young Kwon, Kena Park, Jeong Min Song, Seung Yeon Pyeon, Seon Hwa Lee, Young Shin Chung, Jong-Min Lee
Summary: This study evaluated the risk factors for stroke and its prognosis in patients with gynecological cancers. Stroke had a higher occurrence rate in these patients compared to the general population and was significantly associated with age and hypertension. However, it was not found to be an independent prognostic factor for progression-free or overall survival. Therefore, an appropriate management plan considering the patient's age, medical history, and tumor characteristics is important.
Article
Oncology
Michael Hauptmann, Graham Byrnes, Elisabeth Cardis, Marie-Odile Bernier, Maria Blettner, Jeremie Dabin, Hilde Engels, Tore S. Istad, Christoffer Johansen, Magnus Kaijser, Kristina Kjaerheim, Neige Journy, Johanna M. Meulepas, Monika Moissonnier, Cecile Ronckers, Isabelle Thierry-Chef, Lucian Le Cornet, Andreas Jahnen, Roman Pokora, Magda Bosch de Basea, Jordi Figuerola, Carlo Maccia, Arvid Nordenskjold, Richard W. Harbron, Choonsik Lee, Steven L. Simon, Amy Berrington de Gonzalez, Joachim Schuz, Ausrele Kesminiene
Summary: The European EPI-CT study aims to assess the risk of brain cancer from CT examinations in children and young adults. Using data from nine European countries, the study found a significant dose-response relationship between CT-related radiation exposure and brain cancer.
Article
Oncology
Nicolas R. Smoll, Zoe Brady, Katrina J. Scurrah, Choonsik Lee, Amy Berrington de Gonzalez, John D. Mathews
Summary: This study found that about 40% of brain tumors in children may be attributable to CT radiation rather than reverse causation. However, due to a relatively low rate of CT scanning in Australia, only 3.7% of all brain cancers are attributable to CT scans. The population-attributable fraction may be greater in countries with higher rates of pediatric scanning.
Editorial Material
Public, Environmental & Occupational Health
Mary K. Schubauer-Berigan, David B. Richardson, Matthew P. Fox, Lin Fritschi, Irina Guseva Canu, Neil Pearce, Leslie Stayner, Amy Berrington de Gonzalez
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2023)
Article
Oncology
Katherine L. Ho, Meredith S. Shiels, Cody Ramin, Lene H. S. Veiga, Yingxi Chen, Amy Berrington de Gonzalez, Jacqueline B. Vo
Summary: Disparities in cardiovascular disease mortality among breast cancer survivors were found to be influenced by county-level socioeconomic status and rurality. Individuals with lower SES and living in rural areas had higher mortality rates.
JNCI CANCER SPECTRUM
(2023)
Article
Public, Environmental & Occupational Health
Montserrat Garcia-Closas, Thomas U. Ahearn, Mia M. Gaudet, Amber N. Hurson, Jeya Balaji Balasubramanian, Parichoy Pal Choudhury, Nicole M. Gerlanc, Bhaumik Patel, Daniel Russ, Mustapha Abubakar, Neal D. Freedman, Wendy S. W. Wong, Stephen J. Chanock, Amy Berrington de Gonzalez, Jonas S. Almeida
Summary: Data sharing is crucial for reproducibility, replication, pooled analyses, and maximizing study value in epidemiology. Obstacles such as confidentiality, costs, and incentives often hinder data sharing, but practicing the FAIR principles can address these barriers by making data findable, accessible, interoperable, and reusable. Implementing these principles requires moving data to accessible servers, using open-source code, and providing funding, training, and incentives for sharing resources.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Oncology
Anika T. Haque, Amy Berrington de Gonzalez, Yingxi Chen, Emily A. Haozous, Maki Inoue-Choi, Wayne R. Lawrence, Jennifer K. McGee-Avila, Anna M. Napoles, Eliseo J. Perez-Stable, Kekoa Taparra, Jacqueline B. Vo, Neal D. Freedman, Meredith S. Shiels
Summary: The study estimated cancer death rates among different racial and ethnic groups in the United States from 2018 to 2020. The results found significant disparities in cancer death rates, with the highest rates observed among Black individuals and Native Hawaiian and Pacific Islander (NHPI) individuals. Separating NHPI and Asian individuals revealed large differences in cancer mortality between the two groups that were previously combined in vital statistics data.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Multidisciplinary Sciences
Lee J. Mason, Amy Berrington de Gonzalez, Montserrat S. Garcia-Closas, Stephen Chanock, Blanaid Hicks, Jonas Almeida
Summary: This paper introduces EpiForecast, a tool that performs interpretable, non-mechanistic forecasts using interactive visualization and a simple, data-focused forecasting technique. EpiForecast's primary feature is a four-plot interactive dashboard which displays a variety of information to help the user understand how the forecasts are generated.
Article
Oncology
Meredith S. Shiels, Stanley Lipkowitz, Nicole G. Campos, Mark Schiffman, John T. Schiller, Neal D. Freedman, Amy Berrington de Gonzalez
Summary: President Biden and First Lady Dr. Biden have reignited the Cancer Moonshot with the goal of reducing age-standardized cancer mortality rates by at least 50% in the United States over the next 25 years. From 2000 to 2019, overall cancer death rates declined, driven by significant decreases in lung, colorectal, and breast cancer mortality. However, progress for other cancer types was less promising, highlighting the need for new strategies. Achieving the Moonshot goal requires maintaining or accelerating progress in controlling lung, colorectal, and breast cancer deaths, and developing new approaches for prostate, liver, pancreatic, and other cancers.
Article
Oncology
Kishan J. Pithadia, Pragati G. Advani, Deborah E. Citrin, Justin E. Bekelman, Diana R. Withrow, Amy Berrington de Gonzalez, Lindsay M. Morton, Sara J. Schonfeld
Summary: A retrospective cohort study found that intensity-modulated radiotherapy (IMRT) for prostate cancer is not associated with an increased risk of second primary cancers. Any inverse associations may be correlated with the calendar year of treatment.
Article
Medical Informatics
Daniel E. Russ, Nicole M. Gerlanc, Brian Shen, Bhaumik Patel, Amy Berrington de Gonzalez, Neal D. Freedman, Julie M. Cusack, Mia M. Gaudet, Montserrat Garcia-Closas, Jonas S. Almeida
Summary: Developed an open-source markup language called Quest for presenting questionnaire content and logic, along with a real-time renderer for testing logic and viewing data structure. Questionnaire markup, such as Quest, can be a standard format for storing and sharing questionnaires, facilitating FAIR data generation and interoperability in epidemiological studies using open-source tools.
BMC MEDICAL INFORMATICS AND DECISION MAKING
(2023)
Article
Oncology
Mark P. Little, Richard Wakeford, Lydia B. Zablotska, David Borrego, Keith T. Griffin, Rodrigue S. Allodji, Florent de Vathaire, Choonsik Lee, Alina V. Brenner, Jeremy S. Miller, David Campbell, Mark S. Pearce, Siegal Sadetzki, Michele M. Doody, Erik Holmberg, Marie Lundell, Benjamin French, Michael Jacob Adams, Amy Berrington de Gonzalez, Martha S. Linet
Summary: In this study, the researchers investigated the risk of leukemia in children exposed to radiation. They found that even at doses below 1 Gy, exposure to radiation increased the risk of developing AML, CML, and ALL.
BRITISH JOURNAL OF CANCER
(2023)
Article
Medicine, General & Internal
Wayne R. Lawrence, Neal D. Freedman, Jennifer K. McGee-Avila, Amy Berrington de Gonzalez, Yingxi Chen, Marc A. Emerson, Gilbert C. Gee, Emily A. Haozous, Anika T. Haque, Maki Inoue-Choi, Sarah S. Jackson, Brittany Lord, Anna M. Napoles, Eliseo J. Perez-Stable, Jacqueline B. Vo, Faustine Williams, Meredith S. Shiels
Summary: From 1999 to 2020, death rates due to external causes, including poisonings, firearms, and other injuries, increased significantly in the US. There were variations in mortality rates among different demographic groups, particularly among American Indian and Alaska Native populations. The findings highlight the urgent need for public health interventions to address the increasing deaths from poisonings and firearm homicides.
JAMA INTERNAL MEDICINE
(2023)
Article
Oncology
Amy Berrington de Gonzalez, Todd M. Gibson, Choonsik Lee, Paul S. Albert, Keith T. Griffin, Cari Meinhold Kitahara, Danping Liu, Matthew M. Mille, Jungwook Shin, Benjamin V. M. Bajaj, Tristin E. Flood, Sara L. Gallotto, Harald Paganetti, Safia K. Ahmed, Bree R. Eaton, Daniel J. Indelicato, Sarah A. Milgrom, Joshua D. Palmer, Sujith Baliga, Matthew M. Poppe, Derek S. Tsang, Kenneth Wong, Torunn I. Yock
Summary: Purpose: Protons have the potential to lower radiation doses to normal tissues, reducing adverse effects, including subsequent cancers. However, the magnitude of this benefit is uncertain and requires direct comparative studies. The Pediatric Proton and Photon Therapy Comparison Cohort aims to meet this need.
ADVANCES IN RADIATION ONCOLOGY
(2023)
Article
Oncology
Cody Ramin, Lene H. S. Veiga, Jacqueline B. Vo, Rochelle E. Curtis, Clara Bodelon, Erin J. Aiello Bowles, Diana S. M. Buist, Sheila Weinmann, Heather Spencer Feigelson, Gretchen L. Gierach, Amy Berrington de Gonzalez
Summary: Breast cancer survivors treated in recent decades have an increased risk of developing second primary cancers. This study found that they had a 70% higher risk of any cancer and a 45% higher risk of non-breast cancer compared to the general population. Enhanced surveillance and efforts to reduce the occurrence of second cancers are needed for breast cancer survivors.
BREAST CANCER RESEARCH
(2023)
Meeting Abstract
Oncology
Jacqueline B. Vo, Cody Ramin, Wayne Lawrence, Ana Barac, Katherine Ho, Jongeun Rhee, Lene H. S. Veiga, Amy Berrington de Gonzalez
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)