Article
Surgery
Zachary M. Callahan, Wennuan Liu, Jun Hou, S. Lilly Zheng, Jamaal Rehman, H. Mason Hedberg, Craig S. Brown, Bailey Su, Mikhail Attaar, Kristine Kuchta, MaryAnn Regner, JoAnn Carbray, Jianfeng Xu, Michael Ujiki
Summary: This study found that patients who progressed from non-dysplastic Barrett's esophagus (NDBE) to high-grade dysplasia (HGD) or esophageal adenocarcinoma (EAC) were older at diagnosis and reported fewer reflux symptoms. Progression was associated with the presence of any somatic DNA copy number alterations (CNAs) and specific CNAs in GATA6 or ERBB2.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Review
Biochemistry & Molecular Biology
Pelin Ergun, Sezgi Kipcak, Serhat Bor
Summary: Barrett's esophagus (BE) is a condition resulting from chronic gastroesophageal reflux disease, which may progress to esophageal adenocarcinoma (EAC). The histological dysplasia grade is commonly used as a biomarker, but its effectiveness is limited due to cost and lack of progression in many BE patients. Clinicians require multiple or more quantitative biomarkers for early diagnosis of EAC, which has high mortality. Epigenetic factors in the early stages of neoplastic transformation show promise as predictive biomarkers. This review summarizes current research on DNA methylations, histone modifications, and noncoding RNAs (miRNAs) during the progression from BE dysplasia to EAC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
James A. Evans, Emanuela Carlotti, Meng-Lay Lin, Richard J. Hackett, Magnus J. Haughey, Adam M. Passman, Lorna Dunn, George Elia, Ross J. Porter, Mairi H. McLean, Frances Hughes, Joanne ChinAleong, Philip Woodland, Sean L. Preston, S. Michael Griffin, Laurence Lovat, Manuel Rodriguez-Justo, Weini Huang, Nicholas A. Wright, Marnix Jansen, Stuart A. C. McDonald
Summary: This study investigated the distribution of gland phenotypes in Barrett's esophagus (BE) and found that diverse gland phenotypes represent an evolutionary process, with changes in gland diversity potentially playing a role in disease progression.
Article
Oncology
Carlijn A. M. Roumans, Pauline A. Zellenrath, Ewout W. Steyerberg, Iris Lansdorp-Vogelaar, Michael Doukas, Katharina Biermann, Joyce Alderliesten, Gert van Ingen, Wouter B. Nagengast, Arend Karrenbeld, Frank ter Borg, Mariska Hage, Pieter C. J. ter Borg, Michael A. den Bakker, Alaa Alkhalaf, Frank C. P. Moll, Lieke Brouwer-Hol, Joop van Baarlen, Rutger Quispel, Arjan van Tilburg, Jordy P. W. Burger, Antonie J. P. van Tilburg, Ariadne H. A. G. Ooms, Thjon J. Tang, Marielle J. L. Romberg-Camps, Danny Goudkade, Marco J. Bruno, Dimitris Rizopoulos, Manon C. W. Spaander
Summary: Barrett's esophagus (BE) is the precursor lesion of esophageal adenocarcinoma (EAC). The cost-effectiveness of current surveillance strategies for BE is debatable. This multicenter prospective cohort study aimed to evaluate sex differences in 868 BE patients. The results showed that males had higher risk and shorter time to neoplastic progression, while females were more likely to be diagnosed with (advanced) EAC. These findings can guide the development of sex-specific guidelines and improve neoplastic risk stratification in BE surveillance.
Article
Gastroenterology & Hepatology
Allon Kahn, Julia Crook, Michael G. Heckman, Mikolaj A. Wieczorek, Sarmed Sami, Diana Snyder, Siddharth Agarwal, Jose Santiago, Jacobo Ortiz Fernandez-Sordo, W. Keith Tan, Ramona Lansing, Kenneth K. Wang, Krish Ragunath, Massimiliano DiPietro, Herbert Wolfsen, Francisco Ramirez, David Fleischer, Cadman L. Leggett, Prasad G. Iyer
Summary: This study proposes optimal surveillance intervals after complete eradication of intestinal metaplasia (CE-IM) based on a multicenter international cohort, aiming to reduce the endoscopic burden for patients.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Multidisciplinary Sciences
Chunyang Bao, Richard W. Tourdot, Gregory J. Brunette, Chip Stewart, Lili Sun, Hideo Baba, Masayuki Watanabe, Agoston T. Agoston, Kunal Jajoo, Jon M. Davison, Katie S. Nason, Gad Getz, Kenneth K. Wang, Yu Imamura, Robert Odze, Adam J. Bass, Matthew D. Stachler, Cheng-Zhong Zhang
Summary: By analyzing chromosomal copy-number evolution in early cancers and precancerous lesions of the esophagus, the authors reveal signatures of ongoing chromosomal instability and its role in promoting tumor progression.
NATURE COMMUNICATIONS
(2023)
Article
Gastroenterology & Hepatology
Vidhi Patel, Madhusudhan R. Sanaka, Yi Qin, John McMichael, James Bena, Claire Beveridge, John Barron, Siva Raja, Jamak Modaresi Esfeh, Prashanthi N. Thota
Summary: This retrospective cohort study demonstrates that immunosuppressant use is associated with neoplastic progression in Barrett's esophagus (BE) patients, while solid organ transplantation (SOT) is not. Therefore, close surveillance of BE patients on chronic immunosuppressants needs to be considered.
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Article
Gastroenterology & Hepatology
Kazuaki Norita, Tomoyuki Koike, Masahiro Saito, Hirohiko Shinkai, Reiko Ami, Yasuhiko Abe, Naohiro Dairaku, Yoshifumi Inomata, Shoichi Kayaba, Fumitake Ishiyama, Tomoyuki Oikawa, Motoki Ohyauchi, Hirotaka Ito, Sho Asonuma, Tatsuya Hoshi, Katsuaki Kato, Shuichi Ohara, Yosuke Shimodaira, Kenta Watanabe, Tooru Shimosegawa, Atsushi Masamune, Katsunori Iijima
Summary: This study followed 98 patients with Barrett's esophagus (BE) of maximum length ≥ 2 cm in Japan for over 5 years and found that the incidence of esophageal adenocarcinoma (EAC) was 0.47% per year, lower than the previously reported 1.2% per year. Further large-scale studies are needed to validate these results.
DIGESTIVE ENDOSCOPY
(2021)
Article
Multidisciplinary Sciences
A. C. Katz-Summercorn, S. Jammula, A. Frangou, I Peneva, M. O'Donovan, M. Tripathi, S. Malhotra, M. di Pietro, S. Abbas, G. Devonshire, W. Januszewicz, A. Blasko, K. Nowicki-Osuch, S. MacRae, A. Northrop, A. M. Redmond, D. C. Wedge, R. C. Fitzgerald
Summary: In this study, a multi-omics analysis was performed on a cohort of Barrett's esophagus patients, revealing the impact of structural variants on disease progression and molecular events. The results show that genomic complexity occurs early in Barrett's esophagus and is associated with increased gene expression related to chromosomal instability, cell cycle, and DNA repair.
NATURE COMMUNICATIONS
(2022)
Article
Gastroenterology & Hepatology
Richard Phillips, Wladyslaw Januszewicz, Nastazja D. Pilonis, Maria O'Donovan, Tarek Sawas, David A. Katzka, Rebecca C. Fitzgerald, Massimiliano di Pietro
Summary: Patients with BE-IND have a high risk of neoplastic progression and need close monitoring. BE length is associated with neoplastic progression.
GASTROINTESTINAL ENDOSCOPY
(2021)
Article
Biochemistry & Molecular Biology
Aubrey K. Hubbard, Derek W. Brown, Weiyin Zhou, Shu-Hong Lin, Giulio Genovese, Stephen J. Chanock, Mitchell J. Machiela
Summary: Age-related clonal expansion of cells with chromosomal alterations is an important aspect of clonal haematopoiesis. This study investigated the association between widely measured serum biomarkers and clonal expansion of cells with chromosomal alterations, providing new insights into the molecular changes that promote acquisition and expansion of these cells. The results showed that commonly measured serum biomarkers related to lipid levels, sex hormones, blood sugar homeostasis, inflammation and immune function, vitamins and minerals, kidney function, and liver function were associated with clonal expansion. The findings suggest that the mechanisms underlying these diseases may be related to clonal cell proliferation and expansion.
HUMAN MOLECULAR GENETICS
(2023)
Review
Microbiology
Caitlin Guccione, Rena Yadlapati, Shailja Shah, Rob Knight, Kit Curtius
Summary: Esophageal adenocarcinoma (EAC) is a deadly disease with a high mortality rate, and its precursor Barrett's esophagus (BE) has been rapidly increasing since the 1970s. Changes in the esophageal microbiome in modern populations may help explain the rise in EAC cases, and non-invasive procedures to detect microbial communities in saliva, oral swabs, and brushings may offer an alternative means of BE detection. Further studies are needed to understand the dynamic changes in microbial communities within BE and their potential causal role in cancer formation.
Review
Gastroenterology & Hepatology
Shashank Garg, Jesse Xie, Sumant Inamdar, Sheila L. Thomas, Arvind J. Trindade
Summary: Dysplasia in Barrett's esophagus is predominantly located in the right half of the esophagus before ablation therapy. Post-ablation recurrence of dysplasia is more commonly found at the top of the gastric folds and is non-visible compared to the tubular esophagus.
Article
Multidisciplinary Sciences
Chinthalapally V. V. Rao, Chao Xu, Yuting Zhang, Adam S. S. Asch, Hiroshi Y. Y. Yamada
Summary: This study identified specific genes associated with genomic instability in colorectal cancer, providing new insights and targets for the development of therapeutic approaches.
SCIENTIFIC REPORTS
(2022)
Article
Gastroenterology & Hepatology
Siddharth Agarwal, Mohammad Alshelleh, Jamie Scott, Lovekirat Dhaliwal, D. Chamil Codipilly, Ross Dierkhising, Cadman L. Leggett, Kenneth K. Wang, Fouad A. Otaki, Arvind J. Trindade, Prasad G. Iyer
Summary: This study compared the effectiveness and safety of radiofrequency ablation (RFA) and cryoballoon ablation (CBA) in the treatment of dysplastic Barrett's esophagus (BE). The histologic outcomes of endoscopic eradication therapy (EET) using RFA and CBA were found to be comparable. A randomized trial is needed to definitively compare outcomes between these two modalities.
GASTROINTESTINAL ENDOSCOPY
(2022)
Article
Oncology
Mary K. Kuhner, Rumen Kostadinov, Brian J. Reid
CANCER PREVENTION RESEARCH
(2016)
Article
Biochemical Research Methods
Rumen Kostadinov, Carlo C. Maley, Mary K. Kuhner
PLOS COMPUTATIONAL BIOLOGY
(2016)
Article
Genetics & Heredity
Patricia C. Galipeau, Kenji M. Oman, Thomas G. Paulson, Carissa A. Sanchez, Qing Zhang, Jerry A. Marty, Jeffrey J. Delrow, Mary K. Kuhner, Thomas L. Vaughan, Brian J. Reid, Xiaohong Li
Article
Oncology
Michael J. Burke, Rumen Kostadinov, Richard Sposto, Lia Gore, Shannon M. Kelley, Cara Rabik, Jane B. Trepel, Min-Jung Lee, Akira Yuno, Seonju Lee, Deepa Bhojwani, Sima Jeha, Bill H. Chang, Maria Luisa Sulis, Michelle L. Hermiston, Paul Gaynon, Van Huynh, Anupam Verma, Rebecca Gardner, Kenneth M. Heym, Robyn M. Dennis, David S. Ziegler, Theodore W. Laetsch, Javier E. Oesterheld, Steven G. Dubois, Jessica A. Pollard, Julia Glade-Bender, Todd M. Cooper, Joel A. Kaplan, Midhat S. Farooqi, Byunggil Yoo, Erin Guest, Alan S. Wayne, Patrick A. Brown
CLINICAL CANCER RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Kevin Hadi, Xiaotong Yao, Julie M. Behr, Aditya Deshpande, Charalampos Xanthopoulakis, Huasong Tian, Sarah Kudman, Joel Rosiene, Madison Darmofal, Joseph DeRose, Rick Mortensen, Emily M. Adney, Alon Shaiber, Zoran Gajic, Michael Sigouros, Kenneth Eng, Jeremiah A. Wala, Kazimierz O. Wrzeszczynski, Kanika Arora, Minita Shah, Anne-Katrin Emde, Vanessa Felice, Mayu O. Frank, Robert B. Darnell, Mahmoud Ghandi, Franklin Huang, Sally Dewhurst, John Maciejowski, Titia de Lange, Jeremy Setton, Nadeem Riaz, Jorge S. Reis-Filho, Simon Powell, David A. Knowles, Ed Reznik, Bud Mishra, Rameen Beroukhim, Michael C. Zody, Nicolas Robine, Kenji M. Oman, Carissa A. Sanchez, Mary K. Kuhner, Lucian P. Smith, Patricia C. Galipeau, Thomas G. Paulson, Brian J. Reid, Xiaohong Li, David Wilkes, Andrea Sboner, Juan Miguel Mosquera, Olivier Elemento, Marcin Imielinski
Article
Evolutionary Biology
Lucian P. Smith, Jon A. Yamato, Patricia C. Galipeau, Thomas G. Paulson, Xiaohong Li, Carissa A. Sanchez, Brian J. Reid, Mary K. Kuhner
Summary: Barrett's Esophagus is a neoplastic condition that can progress to esophageal adenocarcinoma. Early steps in the formation of the Barrett's segment strongly influence whether patients will develop cancer in the future.
EVOLUTIONARY APPLICATIONS
(2021)
Article
Surgery
Luigi Marchionni, Francisco Pereira Lobo, Rumen Kostadinov, Anna Serra, Federico Genzano Besso, Silvia Deaglio, Piero Stratta, Monica Berrino, Claudio Zanettini, Eddie Luidy Imada, Mohamed N. Omar, Gianluca Gaidano, Benedetto Bruno, Giuseppe Saglio, Antonio Amoroso
Summary: We report a case of transmission of AML from a self-donor to two kidney and one liver recipients. The recipients showed donor chimerism and distinct clonal evolution, providing a potential molecular explanation for tumor escape.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Meeting Abstract
Hematology
Jillian Fry, Midhat S. Farooqi, Byunggil Yoo, Rumen Kostadinov, Emily Farrow, Shannon Kelley, Margaret Gibson, Neil Miller, Jeffrey Johnston, Patrick Brown, Erin Guest
Meeting Abstract
Oncology
E. Guest, B. Yoo, M. Farooqi, N. Miller, J. Johnston, R. Kostadinov, E. Farrow, S. Kelley, M. Gibson, P. Brown
PEDIATRIC BLOOD & CANCER
(2017)
Meeting Abstract
Oncology
Byunggil Yoo, Midhat S. Farooqi, Rumen Kostadinov, Neil Miller, Jeff Johnston, Emily Farrow, Shannon Kelley, Margaret Gibson, Patrick Brown, Erin Guest
Article
Biochemistry & Molecular Biology
Jason A. Somarelli, Kathryn E. Ware, Rumen Kostadinov, Jeffrey M. Robinson, Hakima Amri, Mones Abu-Asab, Nicolaas Fourie, Rui Diogo, David Swofford, Jeffrey P. Townsend
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2017)
Meeting Abstract
Hematology
Rumen Kostadinov, Midhat Farooqi, Byunggil Yoo, Emily Farrow, Shannon Kelley, Margaret Gibson, Neil Miller, Erin M. Guest, Patrick Brown
Meeting Abstract
Hematology
Jevon Cutler, Raiha Tahir, Rumen Kostadinov, Raja Sekhar, Tai-Chung Huang, Akhilesh Pandey, Patrick Brown, Mohammad Heydarian, Karen Reddy
Meeting Abstract
Hematology
Genevieve Marie Crane, Helen Powell, Rumen Kostadinov, Peter C. Burger, Richard F. Ambinder, Lode J. Swinnen, Michael J. Borowitz, Amy S. Duffield
Meeting Abstract
Hematology
Rumen Kostadinov, Robert Scharpf, Patrick Brown