Article
Medicine, General & Internal
Indah Jamtani, Kwang-Woong Lee, Yunhee Choi, YoungRok Choi, Jeong-Moo Lee, Eui-Soo Han, Kwangpyo Hong, Gyu-Seong Choi, Jong Man Kim, Nam-Joon Yi, Suk Kyun Hong, Jeik Byun, Su Young Hong, Sanggyeun Suh, Jae-Won Joh, Kyung-Suk Suh
Summary: This study aimed to develop a tailored prediction model of HCC-specific survival after transplantation, validated internally and externally. By combining multiple risk factors, the model showed good accuracy in predicting HCC-specific survival tailored for patients undergoing transplantation. The calculated SALT predictor provided accurate information on expected survival rates based on risk scores and specific characteristics.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Immunology
Kathryn A. Knoop, Keely G. McDonald, Chyi-Song Hsieh, Phillip Tarr, Rodney D. Newberry
Summary: Atopic disorders are on the rise in Western societies, characterized by immune responses to environmental triggers. Early life exposure to diet and microbes shapes the intestinal Treg population significantly. Tregs developed early in life play a crucial role in restraining systemic inflammatory responses into adulthood.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Christina Seitz, Anne-Laure Joly, Fang Fang, Katie Frith, Paul Gray, John Andersson
Summary: The transcription factor FOXP3 is crucial for the development and function of CD4(+)FOXP3(+) regulatory T (Treg) cells. Alterations in the expression of FOXP3 isoforms are associated with inflammatory disease progression. This study investigates the effects of a specific FOXP3 mutation on Treg cell subsets. The findings suggest that the full-length FOXP3 isoform is important for maintaining Treg cell lineage stability but not essential for Treg cell activation.
CLINICAL IMMUNOLOGY
(2022)
Article
Immunology
Lauren Van Zeebroeck, Rebeca Arroyo Hornero, Beatriz F. Corte-Real, Ibrahim Hamad, Torsten B. Meissner, Markus Kleinewietfeld
Summary: Tregs are crucial for maintaining immune homeostasis and have potential therapeutic value in various diseases. While current genome editing protocols for Tregs are limited, our rapid and effective method may advance possibilities for Treg-based cellular therapies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Beatriz F. F. Corte-Real, Rebeca Arroyo Hornero, Aleksandra Dyczko, Ibrahim Hamad, Markus Kleinewietfeld
Summary: CSF2RB (CD131) may serve as a potential biomarker for autoimmune diseases in Tregs, with its overexpression potentially being linked to disease development.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Yiran Qiu, Shouyu Ke, Jieqiong Chen, Zhizhen Qin, Wenle Zhang, Yaqin Yuan, Dehua Meng, Gang Zhao, Kejin Wu, Bin Li, Dan Li
Summary: This review summarizes the latest findings on the dynamic connections and reciprocal regulations of non-lymphoid Treg cell subsets in the immune escape of tumour cells in solid tumors, providing new insights for the development of next-generation engineered T cell-based immune treatments for solid tumors.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Disha Rao, Johanna A. A. Stunnenberg, Ruben Lacroix, Petros Dimitriadis, Joanna Kaplon, Fabienne Verburg, Paula T. T. van van Royen, Esmee P. Hoefsmit, Kathrin Renner, Christian U. U. Blank, Daniel S. S. Peeper
Summary: Glucose limitation and increased lactic acid levels due to elevated glycolytic activity of tumor cells create a metabolic barrier for tumor infiltrating immune cells. Regulatory T cells (Tregs) are not inhibited in lactic acid-rich environments, and lactic acid enhances the induction of Tregs. Acidicity in the tumor microenvironment can be targeted therapeutically to reduce Treg-mediated immune suppression within tumors.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Review
Immunology
Tracoyia Roach, Laurence Morel
Summary: Immune homeostasis relies on the balance between effector T cells and regulatory T cells. Studies have identified genetic factors that maintain the stability and suppressive function of regulatory T cells, which could potentially be targeted for therapeutic intervention against autoimmunity.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Biaolong Deng, Weiqi Zhang, Yicheng Zhu, Yangyang Li, Dan Li, Bin Li
Summary: Regulatory T (Treg) cells play a critical role in maintaining immune homeostasis and their dysfunction in aged patients may contribute to age-related diseases. Immune therapies targeting Treg cells show promising results in treating cancers and autoimmune diseases. Understanding Treg cell function better may help in developing new immune therapies against aging.
Article
Biochemical Research Methods
Shuai Yang, Jiangang Zhang, Jingchun Wang, Yanquan Xu, Huakan Zhao, Juan Lei, Yu Zhou, Yu Chen, Lei Wu, Mingyue Zhou, Dingshan Li, Enwen Wang, Yongsheng Li
Summary: A robust prognostic nomogram for predicting the prognosis of patients with HCC was developed. The results suggested that Th2 cells, VEGF-related angiogenesis, and HIF1A-related hypoxia may be promising therapeutic targets for prolonging the overall survival of HCC patients.
CURRENT BIOINFORMATICS
(2022)
Article
Gastroenterology & Hepatology
Feng Zhang, Keshu Hu, Bei Tang, Mengxin Tian, Shenxin Lu, Jia Yuan, Miao Li, Rongxin Chen, Zhenggang Ren, Yinghong Shi, Xin Yin
Summary: A new scoring method (PSM-CHCC model) was developed for personalized prognostic prediction in cHCC-CCA patients undergoing surgical resection, outperforming current prognostic staging systems. Subgroup analysis confirmed the discrimination efficacy of the PSM-CHCC model, which may aid in prognostic stratification and clinical decision-making.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Oncology
Zhaowei Wang, Lei He, Weina Li, Chuanyang Xu, Jieyu Zhang, Desheng Wang, Kefeng Dou, Ran Zhuang, Boquan Jin, Wei Zhang, Qiang Hao, Kuo Zhang, Wangqian Zhang, Shuning Wang, Yuan Gao, Jintao Gu, Lei Shang, Zhijun Tan, Haichuan Su, Yingqi Zhang, Cun Zhang, Meng Li
Summary: This study highlights the role of GDF15 in promoting Treg cell expansion and enhancing their suppressive function in HCC, with CD48 identified as a receptor for GDF15 in the immune system. Inhibiting GDF15 shows promising results in reversing HCC-related immunosuppression. The findings suggest a potential new target for immunotherapy in HCC.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Immunology
Qi Wang, Wenying Qiao, Honghai Zhang, Biyu Liu, Jianjun Li, Chaoran Zang, Tingting Mei, Jiasheng Zheng, Yonghong Zhang
Summary: This study established a prediction model for predicting recurrence in early-stage HCC based on the Lasso-Cox regression model. The nomogram plotted based on the model has a better predictive ability and can guide the screening of populations at high risk of recurrence after treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Juyeun Lee, Dongkyun Kim, Booki Min
Summary: Foxp3(+) regulatory T (Treg) cells are crucial for immune regulation and tolerance, and tissue resident Treg cells play a central role in regulating tissue homeostasis, inflammation, and repair.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, Research & Experimental
Vahid Karpisheh, Seyedeh Mahboubeh Mousavi, Parinaz Naghavi Sheykholeslami, Mehrdad Fathi, Mehran Mohammadpour Saray, Leili Aghebati-Maleki, Reza Jafari, Naime Majidi Zolbanin, Farhad Jadidi-Niaragh
Summary: Treg cells play a critical role in the progression of prostate cancer, with higher levels of Tregs associated with an increased risk of cancer recurrence. Suppressing Tregs or depleting Tregs may be an effective strategy for prostate cancer immunotherapy.