Letter
Chemistry, Medicinal
Alberto Boretti
Summary: Quercetin has a wide range of potential health benefits as it can act as a supplement or treatment for various conditions. It possesses antioxidant and anti-inflammatory properties, making it a potential cancer chemopreventive and chemotherapeutic agent that can kill cancer cells and possess senolytic properties. While clinical trials are needed for specific drug uses, it can be used as a general chemo-preventive supplement without contraindications.
PHYTOTHERAPY RESEARCH
(2023)
Article
Chemistry, Medicinal
Lei Jing, Jieru Lin, Yang Yang, Li Tao, Yuyin Li, Zhenxing Liu, Qing Zhao, Aipo Diao
Summary: Quercetin dihydrate can inhibit the interaction of PD-1/PD-L1, enhance the killing activity of T cells on cancer cells, and exhibit anti-tumor effects in mouse experiments.
PHYTOTHERAPY RESEARCH
(2021)
Review
Medicine, Research & Experimental
Soudeh Ghafouri-Fard, Hamed Shoorei, Ali Khanbabapour Sasi, Mohammad Taheri, Seyed Abdulmajid Ayatollahi
Summary: Quercetin, a flavonoid found in various plants, exerts beneficial effects on human health by mediating antioxidant activities, immune-modulatory impacts, and regulating metabolic pathways. These effects are likely induced through modulation of signaling pathways and gene expression.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Fabienne Bejjani, Claire Tolza, Mathias Boulanger, Damien Downes, Raphael Romero, Muhammad Ahmad Maqbool, Amal Zine El Aabidine, Jean-Christophe Andrau, Sophie Lebre, Laurent Brehelin, Hughes Parrinello, Marine Rohmer, Tony Kaoma, Laurent Vallar, Jim R. Hughes, Kazem Zibara, Charles-Henri Lecellier, Marc Piechaczyk, Isabelle Jariel-Encontre
Summary: The dimeric transcription factors AP-1, composed of Fos and Jun family proteins, play a key role in gene regulation. The overexpression of the Fos family protein Fra-1 in triple negative breast cancers contributes to tumor aggressiveness, while its actions in controlling transcription remain complex and involve a wide range of biological processes.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Cell Biology
Alessandra Franceschini, Giacomo Mazzamuto, Curzio Checcucci, Lorenzo Chicchi, Duccio Fanelli, Irene Costantini, Maria Beatrice Passani, Bianca Ambrogina Silva, Francesco Saverio Pavone, Ludovico Silvestri
Summary: Fear responses are adaptive behaviors strengthened as memories. Understanding the neural circuitry modulating fear memory is crucial for comprehension of this emotion and its pathological states. The brain-wide neuron quantification toolkit (BRANT) allows for mapping whole-brain neuronal activation at micron-scale resolution, providing a comprehensive characterization of the evolution of fear memory.
Article
Chemistry, Medicinal
Puwei Zhang, Jianing Zhang, Lin Zhao, Shizheng Li, Kun Li
Summary: The study found that quercetin can alleviate AC-induced cardiotoxicity and enhance the antitumor activity of AC in TNBC cells, making it a potential novel agent for treating TNBC.
PHYTOTHERAPY RESEARCH
(2022)
Article
Oncology
Hiroyuki Kato, Aya Naiki-Ito, Shugo Suzuki, Shingo Inaguma, Masayuki Komura, Kenju Nakao, Taku Naiki, Kenta Kachi, Akihisa Kato, Yoichi Matsuo, Satoru Takahashi
Summary: The study found that the flavonoid Luteolin (Lut) has chemopreventive effects on pancreatic cancer in a hamster model, potentially through inhibiting the STAT3-DPYD pathway. Additionally, high expression of DPYD in human PDAC was associated with poor prognosis.
Article
Multidisciplinary Sciences
Yarely C. Hoffiz, Alexandra Castillo-Ruiz, Megan A. L. Hall, Taylor A. Hite, Jennifer M. Gray, Carla D. Cisternas, Laura R. Cortes, Andrew J. Jacobs, Nancy G. Forger
Summary: Research showed that birth triggers neural activation in the hypothalamus, predominantly in vasopressinergic neurons. Levels of vasopressin increase significantly before birth, with different levels released after vaginal and C-section births, impacting neurodevelopment.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Liyuan Wang, Chan Chen, Zemin Song, Honghong Wang, Minghui Ye, Donghai Wang, Wenqian Kang, Hudan Liu, Guoliang Qing
Summary: This study demonstrates that EZH2 directly interacts with MYC and MYCN, promoting their stabilization in a methyltransferase-independent manner. By competing against SCFFBW7 ubiquitin ligase, EZH2 counteracts the degradation of MYC and MYCN, highlighting their role as global oncogenic effectors of EZH2. This research suggests that pharmacologic degradation of EZH2 may be a potential therapeutic approach for MYC-driven cancers.
NATURE COMMUNICATIONS
(2022)
Article
Plant Sciences
Yujun Tan, Qian Lin, Jingchun Yao, Guimin Zhang, Xue Peng, Jun Tian
Summary: This study evaluated the antifungal capacity of quercetin (QC) against Candida albicans and found that QC can inhibit biofilm formation and adhesion of C. albicans. Oral QC showed a protective effect against C. albicans infection in mice, reducing inflammation and protecting the integrity of the vaginal mucosa.
Article
Physiology
A. B. Cherepov, A. A. Tiunova, K. V. Anokhin
Summary: Newly hatched chicks show a preference for naturalistic stimuli, but artificial imprinting stimuli can initially elicit a stronger response. However, over time, the preference for artificial stimuli decreases and is replaced by a preference for natural stimuli.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
James T. Leech, Andrew Brennan, Nicola A. Don, Jody M. Mason, Neil M. Kad
Summary: The AP-1 transcription factor family plays a crucial role in regulating the cell cycle and has various functions in proliferation, differentiation, and stress response. This study shows that cFos can bind to DNA independently of cJun and can interact with DNA as both monomers and dimers.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Behavioral Sciences
Alejandro Borja Grau-Perales, Fernando Gamiz, Milagros Gallo
Summary: Research has shown that the hippocampal administration of 6-OHDA disrupts context-dependent taste recognition memory, indicating that auditory background can modulate safe taste memory acquisition through catecholaminergic activity in the hippocampus.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Multidisciplinary Sciences
Mariann Eilertsen, Benjamin G. J. Clokie, Lars O. E. Ebbesson, Cristina Tanase, Herve Migaud, Jon Vidar Helvik
Summary: Photoreceptive inputs to the teleost brain are perceived as images of the visual world and modulation of neuroendocrine and neuronal signals. This study tested the effects of narrow bandwidth light on brain neural activity in Atlantic salmon, revealing an increase in c-fos expression and activation of specific brain regions following light stimulation. The overlapping expression patterns of c-fos and nonvisual opsins suggest a direct light stimulation of deep brain photoreceptors.
Article
Oncology
Cristian Prieto-Garcia, Oliver Hartmann, Michaela Reissland, Fabian Braun, Suleyman Bozkurt, Nikolett Pahor, Carmina Fuss, Andreas Schirbel, Christina Schuelein-Voelk, Alexander Buchberger, Marco A. Calzado Canale, Mathias Rosenfeldt, Ivan Dikic, Christian Muench, Markus E. Diefenbacher
Summary: The oncogenic transformation of lung epithelial cells is a complex process involving the regulation of protein abundance of proto-oncogenes, such as c-JUN and c-MYC, by USP28. Inhibition of USP28 activity shows potential for the treatment of early-stage lung tumors and has synergistic effects with existing inhibitors targeting specific mutations.
MOLECULAR ONCOLOGY
(2022)