Article
Biotechnology & Applied Microbiology
Lijun Zhong, Lin Tang, Xiaoxia He
Summary: It has been discovered that ANGPTL3 plays an oncogenic role in several types of human malignancies. This study found that ANGPTL3 is highly expressed in cervical cancer cells and silencing ANGPTL3 can inhibit cell proliferation, migration, invasion, and angiogenesis. The inhibitory effect of ANGPTL3 can be offset by upregulating the expression of alpha v beta 3, which also promotes blood vessel formation and the secretion of VEGF and VEGFR2 in cervical cancer cells.
Article
Medicine, Research & Experimental
Lei Xiang, Qi Rao, Bin He, Xiao-hong Guo, Yun-dan Xu, Bao-ping Luo, Gang Zhao, Feng-hua Wu
Summary: This study found that breast cancer cells overexpressing cyclin D1b can induce the differentiation of macrophages into a tumor-associated macrophage-like phenotype, which promotes tumor metastasis.
CURRENT MEDICAL SCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Ewa Brzozowska, Sameer Deshmukh
Summary: Integrins are crucial for cell adhesion, migration, and positioning. Studies have shown that the expression levels of Integrin αVβ6 are closely related to malignant diseases and patient prognosis. It plays a significant role in cancer progression and the activation of transforming growth factor β(TGF-β). While essential for normal function in healthy individuals, it can also be a target for cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Sophie Ayama-Canden, Rodolfo Tondo, Liliana Pineros, Noelle Ninane, Catherine Demazy, Marc Dieu, Antoine Fattaccioli, Tijani Tabarrant, Stephane Lucas, Davide Bonifazi, Carine Michiels
Summary: In the context of breast cancer metastasis study, the study investigated the regulation mechanism of cell migration and found that the IGDQ fibronectin motif activates integrin and influences cell migration. Integrins α5 and αv are related to cell migration, and they control cell migration by regulating the expression and function of ITGA5 and ITGB3.
Article
Radiology, Nuclear Medicine & Medical Imaging
Liang Zhao, Xuejun Wen, Weizhi Xu, Yizhen Pang, Long Sun, Xiaoming Wu, Pengfei Xu, Jingjing Zhang, Zhide Guo, Qin Lin, Xiaoyuan Chen, Haojun Chen
Summary: This study evaluated the radiolabeled FAPI-RGD heterodimer using Ga-68 for imaging in cancer patients. The results showed that Ga-68-FAPI-RGD had improved tumor uptake and tumor-to-background ratio compared to F-18-FDG and Ga-68-FAPI PET/CT. The study concluded that Ga-68-FAPI-RGD PET/CT is safe and clinically feasible for imaging various types of cancer.
JOURNAL OF NUCLEAR MEDICINE
(2023)
Review
Endocrinology & Metabolism
Aleck Hercbergs, Hung-Yun Lin, Shaker A. Mousa, Paul J. Davis
Summary: Thyroid hormone acts on cancer cells through its receptor on the cell surface to promote cell proliferation. It can promote the growth of estrogen receptor-positive breast cancer cells in the absence of estrogen. Additionally, it may contribute to aggressive breast cancer behavior by stimulating immune checkpoint inhibitor gene expression and anti-apoptosis mechanisms.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Milene N. O. Moritz, Alyssa R. Merkel, Ean G. Feldman, Heloisa S. Selistre-de-Araujo, Julie A. Rhoades (Sterling)
Summary: The expression of α2β1 integrin is inversely correlated with bone metastatic potential in breast cancer. Overexpression of the α2 integrin subunit increases primary tumor growth and dissemination to bone, with no impact on tumor establishment and bone destruction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Yi-Fong Chen, Yung-Ning Yang, Hung-Ru Chu, Tung-Yung Huang, Shwu-Huey Wang, Han-Yu Chen, Zi-Lin Li, Yu-Chen S. H. Yang, Hung-Yun Lin, Aleck Hercbergs, Jacqueline Whang-Peng, Kuan Wang, Paul J. Davis
Summary: The study reveals that doxycycline inhibits proliferation and downregulates PD-L1 gene expression in breast cancer cells, possibly by interacting with integrin alpha v beta 3 and inhibiting ERK1/2 activation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jingyi Zhu, Wenjuan Li, Jian Jing
Summary: Tumor tissues exhibit unique integrin receptor presentation during development, which can be targeted for antitumor therapy. A novel fusion protein called Echistatin-Annexin V (EAV) was developed, which showed strong inhibitory effects on melanoma tumor cells and angiogenesis in mouse models. The unique biological effects of EAV are based on its high selectivity for specific integrin receptors and its ability to bind to phosphatidylserine molecules. EAV-mediated tumor suppression provides a possible mechanism for the treatment of melanoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Dan-yang Guo, Zhong-hua Chen, Yi-fei Fu, Yue-yue Li, Meng-nan Chen, Jun-jie Wu, Zheng-dong Yuan, Jun-Xing Ye, Xia Li, Feng-lai Yuan
Summary: By blocking the signaling pathway of integrin alpha(v)beta(3), cilengitide effectively inhibits the functionality and formation of osteoclasts, resulting in diminished adhesion and bone resorption. The expression of key signaling molecules associated with the osteoclast cytoskeleton are downregulated by cilengitide.
Article
Medicine, Research & Experimental
Jingyun Ren, Shiyu Zhu, Guojin Zhang, Xiaoyue Tan, Ling Qiu, Jianguo Lin, Lei Jiang
Summary: In this study, a PET probe named 68Ga-DOTA-R01-MG was developed for imaging alpha v beta 6-positive lung cancer, which demonstrated excellent stability and specific binding to the target. The probe showed rapid and good tumor uptake and clearance in animal models, indicating its potential as a promising PET tracer for imaging alpha v beta 6-positive lung cancer.
MOLECULAR PHARMACEUTICS
(2022)
Article
Oncology
Marius Kemper, Alina Schiecke, Hanna Maar, Sergey Nikulin, Andrey Poloznikov, Vladimir Galatenko, Michael Tachezy, Florian Gebauer, Tobias Lange, Kristoffer Riecken, Alexander Tonevitsky, Achim Aigner, Jakob Izbicki, Udo Schumacher, Daniel Wicklein
Summary: The knockdown of ITGAV in PDA cells significantly reduces primary tumor growth, peritoneal carcinomatosis, and spontaneous pulmonary metastasis. ITGAV activates latent TGF-beta and drives epithelial-mesenchymal transition. Combined depletion of ITGAV on tumor cells and E- and P-selectins in the tumor-host almost abolishes intraperitoneal spread.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Mark Sutherland, Andrew Gordon, Fatemah O. F. O. Al-Shammari, Adam Throup, Amy Cilia La Corte, Helen Philippou, Steven D. Shnyder, Laurence H. Patterson, Helen M. Sheldrake
Summary: This study presents a new ligand-mimetic beta 3 integrin antagonist that exhibits high activity against alpha v beta 3 and moderate affinity for alpha IIb beta 3, suggesting a new approach to integrin targeting in cancer.
Article
Multidisciplinary Sciences
Zeynep Itah, Shanzah Chaudhry, Sithara Raju Ponny, Ozkan Aydemir, Alexandra Lee, Julie Cavanagh-Kyros, Cathy Tournier, William J. Muller, Roger J. Davis
Summary: The HER2(+) subtype of human breast cancer is associated with the malignant transformation of luminal ductal cells of the mammary epithelium. Loss of function mutations and deletions of the MAP2K4 and MAP2K7genes that encode direct activators of the JUN NH2-terminal kinase (JNK) were found in tumor DNA sequence analysis. In vitro and in vivo studies demonstrated that JNK pathway deficiency promotes HER2(+)-driven breast cancer.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Medicine, Research & Experimental
Yuxue Wang, Yi Liu, Lei Xiang, Lintao Han, Xiaowei Yao, Yibing Hu, Fenghua Wu
Summary: The study found that by overexpressing cyclin D1b, breast cancer cells can regulate macrophage differentiation and promote tumor cell invasion and migration, revealing the important role of cyclin D1b in the breast cancer microenvironment.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2021)
Review
Oncology
Xinru Zhou, Yin Jia, Chuanbin Mao, Shanrong Liu
Summary: Small extracellular vesicles (sEVs), such as exosomes, have emerged as crucial targets for liquid biopsy and promising drug delivery vehicles in tumor progression. They can serve as biomarkers for tumor diagnosis and as drug carriers for cancer treatment.
Article
Oncology
Ruochan Chen, Ju Zhu, Xiao Zhong, Jie Li, Rui Kang, Daolin Tang
Summary: The interplay between autophagy and apoptosis plays a crucial role in tumorigenesis and cancer therapy, with HMGB1 serving as a key regulator in these processes.
Article
Oncology
Zongfu Pan, Xixuan Lu, Tong Xu, Jinming Chen, Lisha Bao, Ying Li, Yingying Gong, Yulu Che, Xiaozhou Zou, Zhuo Tan, Ping Huang, Minghua Ge
Summary: This study uncovered the emerging role of HN1 in promoting dedifferentiation of anaplastic thyroid cancer (ATC) cells. HN1 negatively regulated the thyroid differentiation markers and had an inhibitory effect on the transcriptional activation of CTCF, thereby influencing the chromatin accessibility of thyroid differentiation genes.
Article
Oncology
Yi Qin, Shengjun Xiong, Jun Ren, Gautam Sethi
Summary: Autophagy plays an important regulatory role in glioblastoma, and its dysregulation can lead to drug resistance and radioresistance. It also affects stem cell characteristics, overall growth, and metastasis. Therefore, autophagy is a promising target for glioblastoma therapy.
Article
Oncology
Katsuya Nagaoka, Xuewei Bai, Dan Liu, Kevin Cao, Joud Mulla, Chengcheng Ji, Hongze Chen, Muhammad Azhar Nisar, Amalia Bay, William Mueller, Grace Hildebrand, Jin-Song Gao, Shaolei Lu, Hiroko Setoyama, Yasuhito Tanaka, Jack R. Wands, Chiung-Kuei Huang
Summary: This study found that serum 2-OG levels in cholangiocarcinoma patients are associated with the effectiveness of chemotherapy. Patients with progressive disease showed significantly higher levels of serum 2-OG compared to stable disease and partial response patients. The study also revealed that overexpression of ASPH mimics the effects of 2-OG, and knockdown of ASPH improves chemotherapy. Targeting ASPH enhances the effects of chemotherapy by modulating ATM and ATR, two key regulators of DDRs.