期刊
CANCER LETTERS
卷 353, 期 1, 页码 87-94出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2014.07.008
关键词
FOXC2; Colorectal cancer; Prognosis; Nuclear localization; Proliferation
类别
资金
- National Natural Science Foundation of China [30901791, 81172055, 81071735, 81090422, U1201226]
- National Basic Research Program of China (973 Program) [2010CB529402, 2010CB529403]
- Guangdong Provincial Natural Science Foundation of China [S2012010009643]
- Zhu Jiang Science and Technology New Star Foundation in Guangzhou city [2012J2200052, 2012J2200044]
- Science and Technology Innovation Foundation of Guangdong Higher Education [CXZD1016]
- National Natural Science Foundation of Guangdong, China [2010B031500012]
Abnormal expression of FOXC2 has been found in several human cancers. However, the role of FOXC2 in the progression of colorectal cancer (CRC) has not been well characterized. In analysis of 206 CRC specimens, we revealed that both high expression and nuclear localization of FOXC2 were correlated to aggressive characteristics and poor survival of patients with CRC. FOXC2 promoted cell proliferation through activation of MAPK and ART pathways, subsequently down-regulating p27, up-regulating cyclin D1 and p-FOXO3a. Furthermore, FOXC2 nuclear localization was required for its promotion of cell proliferation. These findings suggest that FOXC2 plays an essential role in CRC progression and may serve as a valuable clinical prognostic marker of this disease. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
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