Review
Biochemistry & Molecular Biology
Rahul Advani, Sara Luzzi, Emma Scott, Caroline Dalgliesh, Joachim Weischenfeldt, Jennifer Munkley, David J. Elliott
Summary: This article discusses the expression of splicing regulators ESRP1 and ESRP2 in aggressively proliferating primary prostate tumors as markers of disease progression. It suggests that ESRP1 and ESRP2 act as lineage survival oncogenes in prostate cancer and highlights the need to identify the gene expression targets controlled by these regulators to develop targeted therapies.
Article
Biochemistry & Molecular Biology
Xiao Liu, Yu He, Yonghua Tong, Qiu Huang, Haojie Shang, Zhiqiang Chen, Kun Tang
Summary: PODNL1 has been identified as a potential therapeutic target and prognostic biomarker for bladder cancer (BLCA). Its high expression is associated with the clinical and pathological characteristics of BLCA, as well as poor prognosis. It plays a role in regulating the proliferation, migration, and epithelial mesenchymal transition (EMT) process of BLCA cells.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Lei Na, Zhuo Wang, Yu Bai, Yu Sun, Dan Dong, Wei Wang, Chenghai Zhao
Summary: This study identified that WNT7B is downregulated in high-grade bladder urothelial carcinomas, and its low expression is associated with poor prognosis. WNT7B inhibits bladder urothelial carcinoma progression by suppressing EMT, stem-like properties, and chemoresistance.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Cell Biology
Yejin Kim, Dahae Lee, Hyejung Jo, Cheolhyeon Go, Jongwon Yang, Dongmin Kang, Jae Seung Kang
Summary: GV1001 effectively suppresses the proliferation of prostate cells, including stromal myofibroblasts and epithelial cells, by regulating cell growth and reducing hypertrophy. It also prevents prostatic fibrosis by inhibiting epithelial-mesenchymal transition through competing with testosterone for binding to androgen receptors, suggesting its potential as a therapeutic drug for BPH with fibrosis.
Article
Cell Biology
Weiyu Wang, Yufan Ying, Haiyun Xie, Jiangfeng Li, Xueyou Ma, Liujia He, Mingjie Xu, Shiming Chen, Haixiang Shen, Xiangyi Zheng, Ben Liu, Xiao Wang, Liping Xie
Summary: Research shows miR-665's role in regulating SMAD3 and SNAIL genes in bladder cancer, making it a potential therapeutic target.
Article
Biochemistry & Molecular Biology
Xiaoqiang Wang, Ruirui Zhang, Tong Wu, Yumiao Shi, Xiao Zhou, Dan Tang, Weifeng Yu, Edmund Cheung So, Xiaodan Wu, Zhiying Pan, Jie Tian
Summary: The study found that successive treatment with naltrexone may promote bladder cancer cell proliferation and induce epithelial-to-mesenchymal transition, along with increased cell migration and invasion abilities. This process may be facilitated through activation of the PI3K/AKT signaling pathway. Consequently, caution should be exercised when using long-term exposure to naltrexone in patients with bladder cancer.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2021)
Review
Oncology
Xiaobo Zheng, Fuzhen Dai, Lei Feng, Hong Zou, Li Feng, Mingqing Xu
Summary: The interplay between epithelial-mesenchymal plasticity and cancer stem cells plays a crucial role in cancer progression, affecting the aggressiveness of tumor cells and their response to treatment. Understanding the dynamic nature of EMT as a hybrid state rather than a binary model is important for unraveling the complexities of cancer biology and developing targeted therapeutic interventions.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Henrik Schinke, Min Pan, Merve Akyol, Jiefu Zhou, Enxian Shi, Gisela Kranz, Darko Libl, Tanja Quadt, Florian Simon, Martin Canis, Philipp Baumeister, Olivier Gires
Summary: pEMT-Singscores serve as a novel risk predictor for HNSCC stratification regarding clinical outcome and therapy response, partly controlled by SLUG.
MOLECULAR ONCOLOGY
(2022)
Article
Oncology
Yaoyao Xiong, Xiongbing Zu, Long Wang, Yuan Li, Minfeng Chen, Wei He, Lin Qi
Summary: The study identified lncRNA VIM-AS1 as highly expressed in bladder cancer, especially in metastatic tissues and high-metastatic cell lines. VIM-AS1 acted as a ceRNA for miR-655, competing with ZEB1 for miR-655 binding, promoting EMT in both high- and low-metastatic bladder cancer cells, and enhancing cancer cell metastasis.
CANCER CELL INTERNATIONAL
(2021)
Review
Biochemistry & Molecular Biology
Claudia Martins-Lima, Ugo Chianese, Rosaria Benedetti, Lucia Altucci, Carmen Jeronimo, Margareta P. Correia
Summary: Bladder cancer is an immunogenic cancer with different stages and treatment options. The tumor microenvironment plays a crucial role in the progression of bladder cancer. Cytokines and chemokines in the microenvironment have dual effects on inflammation and tumor progression. Understanding the immune landscape and cytokine regulation can provide insights into epithelial-mesenchymal transition and metastasis formation in bladder cancer.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Hyun Ji Kim, Mi Kyung Park, Hyun Jung Byun, Minkyoung Kim, Boram Kim, Lu Yu, Tuan Minh Nguyen, Thi Ha Nguyen, Phuong Anh Do, Eun Ji Kim, Ji Hyun Kim, Enkhmend Enkhtaivan, Kyung Sung Kim, Ji Yun Jang, Gyeoung Jin Kang, Ho Lee, Misun Won, Kyeong Lee, Jungsook Cho, Chang Hoon Lee
Summary: LW1497 suppresses cancer progression by inhibiting EMT through downregulation of Slug.
Article
Cell Biology
Zhengnan Huang, Jiakuan Liu, Jiale Yang, Yilin Yan, Chenkai Yang, Xiao He, Ruimin Huang, Mingyue Tan, Denglong Wu, Jun Yan, Bing Shen
Summary: The study identified PDE4B as a potential therapeutic target in urinary bladder cancer, showing that its upregulation promoted cancer cell migration and invasion through the beta-catenin/EMT pathway. Furthermore, PDE4B expression was correlated with aggressive clinicopathological characteristics and unfavorable prognosis in UBC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Dong Han, Jude N. Owiredu, Bridget M. Healy, Muqing Li, Maryam Labaf, Jocelyn S. Steinfeld, Susan Patalano, Shuai Gao, Mingyu Liu, Jill A. Macoska, Kourosh Zarringhalam, Kellee R. Siegfried, Xin Yuan, Timothy R. Rebbeck, Changmeng Cai
Summary: Prostate cancer affects men of African ancestry disproportionately with higher prevalence and worse outcomes compared to American men of European ancestry. Genetic variations such as SNP, particularly in the NEDD9 gene, may play a crucial role in driving racial disparities in prostate cancer aggressiveness and treatment outcomes. The identified prostate cancer susceptibility SNP in NEDD9 increases NEDD9 expression and promotes tumor growth and metastasis, providing new insights into the genetic mechanisms of prostate cancer disparities.
Article
Cell Biology
Dan Dong, Lei Na, Kailing Zhou, Zhuo Wang, Yu Sun, Qianqian Zheng, Jian Gao, Chenghai Zhao, Wei Wang
Summary: The research revealed that FZD5 prevents EMT in gastric cancer and is associated with longer survival. ELF3 acts as a downstream effector of FZD5, repressing ZEB1 expression and guarding against EMT.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Plant Sciences
Yingyu Lu, Ting Guan, Shuoxi Xu, Yong-er Chen, Qi Shen, Shumin Zhu, Ying Liu, Jian Liang, Shaozhen Hou
Summary: Asperuloside shows potential in preventing colorectal cancer by inhibiting epithelial-mesenchymal transition (EMT) development through regulation of VDR/Smad3 pathway. This natural compound exhibits significant anti-tumor effects and may serve as a promising therapeutic agent for colorectal cancer.
Review
Oncology
Xinru Zhou, Yin Jia, Chuanbin Mao, Shanrong Liu
Summary: Small extracellular vesicles (sEVs), such as exosomes, have emerged as crucial targets for liquid biopsy and promising drug delivery vehicles in tumor progression. They can serve as biomarkers for tumor diagnosis and as drug carriers for cancer treatment.
Article
Oncology
Ruochan Chen, Ju Zhu, Xiao Zhong, Jie Li, Rui Kang, Daolin Tang
Summary: The interplay between autophagy and apoptosis plays a crucial role in tumorigenesis and cancer therapy, with HMGB1 serving as a key regulator in these processes.
Article
Oncology
Zongfu Pan, Xixuan Lu, Tong Xu, Jinming Chen, Lisha Bao, Ying Li, Yingying Gong, Yulu Che, Xiaozhou Zou, Zhuo Tan, Ping Huang, Minghua Ge
Summary: This study uncovered the emerging role of HN1 in promoting dedifferentiation of anaplastic thyroid cancer (ATC) cells. HN1 negatively regulated the thyroid differentiation markers and had an inhibitory effect on the transcriptional activation of CTCF, thereby influencing the chromatin accessibility of thyroid differentiation genes.
Article
Oncology
Yi Qin, Shengjun Xiong, Jun Ren, Gautam Sethi
Summary: Autophagy plays an important regulatory role in glioblastoma, and its dysregulation can lead to drug resistance and radioresistance. It also affects stem cell characteristics, overall growth, and metastasis. Therefore, autophagy is a promising target for glioblastoma therapy.
Article
Oncology
Katsuya Nagaoka, Xuewei Bai, Dan Liu, Kevin Cao, Joud Mulla, Chengcheng Ji, Hongze Chen, Muhammad Azhar Nisar, Amalia Bay, William Mueller, Grace Hildebrand, Jin-Song Gao, Shaolei Lu, Hiroko Setoyama, Yasuhito Tanaka, Jack R. Wands, Chiung-Kuei Huang
Summary: This study found that serum 2-OG levels in cholangiocarcinoma patients are associated with the effectiveness of chemotherapy. Patients with progressive disease showed significantly higher levels of serum 2-OG compared to stable disease and partial response patients. The study also revealed that overexpression of ASPH mimics the effects of 2-OG, and knockdown of ASPH improves chemotherapy. Targeting ASPH enhances the effects of chemotherapy by modulating ATM and ATR, two key regulators of DDRs.
