Article
Biochemistry & Molecular Biology
Shuai Qiu, Yimeng Zhou, Jin Tae Kim, Cheng Bao, Hong Jin Lee, Jing Chen
Summary: The study demonstrated that amentoflavone inhibited the migration and invasion of TNF alpha-induced breast cancer cells by modulating the AKT/mTOR/S6K1 signaling pathway, ultimately reducing the invasiveness of human breast cancer cells. Amentoflavone may be considered as a potent food ingredient for slowing down mammary tumorigenesis.
Review
Biochemistry & Molecular Biology
Niraj Kumar Jha, Wei-Chih Chen, Sanjay Kumar, Rajni Dubey, Lung-Wen Tsai, Rohan Kar, Saurabh Kumar Jha, Piyush Kumar Gupta, Ankur Sharma, Rohit Gundamaraju, Kumud Pant, Shalini Mani, Sandeep Kumar Singh, Ricardo B. Maccioni, Tirtharaj Datta, Sachin Kumar Singh, Gaurav Gupta, Parteek Prasher, Kamal Dua, Abhijit Dey, Charu Sharma, Yasir Hayat Mughal, Janne Ruokolainen, Kavindra Kumar Kesari, Shreesh Ojha
Summary: Developmental signalling pathways play a central role in neuronal development and any aberration in these pathways can contribute towards neurological disorders. Extensive research has been conducted in the past decade on these pathways, revealing their potential as therapeutic targets for diseases.
Article
Multidisciplinary Sciences
T. Kloskowski, K. Szeliski, K. Krzeszowiak, Z. Fekner, L. Kazimierski, A. Jundzill, T. Drewa, M. Pokrywczynska
Summary: The study found that Mumio exhibited significant cytotoxicity to urinary bladder cancer cells, while having minimal impact on normal cells. Mumio works by inhibiting the cell cycle of cancer cells and inducing apoptosis.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Marialaura Petroni, Francesca Fabretti, Stefano Di Giulio, Vittoria Nicolis di Robilant, Veronica La Monica, Marta Moretti, Francesca Belardinilli, Francesca Bufalieri, Anna Coppa, Paola Paci, Alessandro Corsi, Enrico De Smaele, Sonia Coni, Gianluca Canettieri, Lucia Di Marcotullio, Zhao-Qi Wang, Giuseppe Giannini
Summary: In this study, the researchers investigated the role of NBN in medulloblastoma (MB) development using a mouse model. They found that monoallelic deletion of the Nbn gene increased MB incidence, while full Nbn knockout impaired MB development. These findings suggest a gene dosage-dependent effect of NBN inactivation on MB development.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2022)
Article
Cell Biology
Dominique Manikowski, Philipp Kastl, Sabine Schuermann, Kristina Ehring, Georg Steffes, Petra Jakobs, Kay Grobe
Summary: The study reveals that C-terminal cholesteroylation of Hedgehog is essential for early steps of production and maturation, but dispensable for signal reception at receiving cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Vida Karimnia, M. Elizabeth Stanley, Christian T. Fitzgerald, Imran Rizvi, Frank J. Slack, Jonathan P. Celli
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a deadly malignancy with obstructed drug delivery and tumor-promoting fibrous stroma. Photodynamic therapy (PDT) has been shown to be feasible and effective for PDAC. This study investigates the ability of photodynamic stromal depletion (PSD) to enhance RNA nanomedicine delivery, and finds that PSD improves the transport of therapeutic nanoparticles and enhances the tumor response to treatment. These findings suggest that PSD could be developed to enhance the delivery of other cancer therapeutics.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2023)
Article
Oncology
Gokce Askan, Ibrahim Halil Sahin, Joanne F. Chou, Aslihan Yavas, Marinela Capanu, Christine A. Iacobuzio-Donahue, Olca Basturk, Eileen M. O'Reilly
Summary: The study found that the expression of CD44 and ESA in PDAC patients is related to tumor stroma type, and tumor stroma may influence recurrence patterns, but there was no significant difference among subgroups in terms of RFS and OS.
Article
Surgery
Ronan J. Kelly, Amir M. Ansari, Tomoharu Miyashita, Marianna Zahurak, Frank Lay, A. Karim Ahmed, Louis J. Born, Maryam K. Pezhouh, Kevan J. Salimian, Christopher Ng, Aerielle E. Matsangos, Anne-Heloise Stricker-Krongrad, Ken-ichi Mukaisho, Guy P. Marti, Christine H. Chung, Marcia I. Canto, Michelle A. Rudek, Stephen J. Meltzer, John W. Harmon
Summary: Itraconazole significantly reduces the development of esophageal adenocarcinoma and SHH expression in a preclinical animal model of Barrett's Metaplasia. In humans, BE tissue expresses higher levels of SHH, Indian Hedgehog, and bone morphogenic protein compared to normal squamous esophageal epithelium.
Review
Biochemistry & Molecular Biology
Marilyn D. Resh
Summary: This review discusses the role of Hedgehog acyltransferase (Hhat) in Hedgehog signaling, the importance of palmitoylation, and the potential involvement of Hhat in various cancers. Targeting hedgehog palmitoylation by inhibiting Hhat is considered a promising intervention in human disease.
Review
Biochemistry & Molecular Biology
Martina Cizmarikova, Radka Michalkova, Ladislav Mirossay, Gabriela Mojzisova, Martina Zigova, Annamaria Bardelcikova, Jan Mojzis
Summary: This review summarizes the role of ellagic acid (EA) as a potential therapeutic agent in cancer prevention and treatment by targeting key hallmarks of cancer. The multifaceted actions of EA make it a promising candidate for cancer prevention and therapy.
Review
Cell Biology
Wanchen Wang, Ryo Shiraishi, Daisuke Kawauchi
Summary: The sonic hedgehog (SHH) pathway plays a crucial role in regulating the development of the central nervous system in vertebrates, and aberrant regulation can lead to neurodevelopmental diseases and brain tumors. Research on the mechanisms of SHH in the cerebellum has shed light on structural abnormalities and medulloblastoma, with current clinical trials exploring novel therapeutic approaches.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
W. Wang, J. Qiu, P. Qu, H. Chen, J. Lan, H. Chen, L. Li, M. Gu
Summary: The study found that dysregulation of the ROC1-SUFU-GLI2 axis plays an important role in bladder cancer progression. ROC1 overexpression promotes bladder cancer cell growth by targeting SUFU for ubiquitin-dependent degradation, resulting in activation of the SHH pathway. Knockdown of SUFU expression partially rescued the ROC1 knockdown-suppressed SHH activity and cancer cell growth.
CANCER CELL INTERNATIONAL
(2021)
Article
Oncology
Yibin Pan, Jiena Zhou, Weidan Zhang, Lili Yan, Meifei Lu, Yongdong Dai, Hanjing Zhou, Songying Zhang, Jianhua Yang
Summary: The study found up-regulation of SHH and accumulation of SQSTM1/P62 in epithelial ovarian cancer. Cyp induced autophagy through the PI3K/AKT signaling pathway, and low-dose Cyp and chloroquine (CQ) significantly promoted the migratory ability of SKOV3 cells. The findings suggest that inhibition of the SHH pathway and autophagy may be a potential and effective therapy for the treatment of ovarian cancer.
Article
Chemistry, Medicinal
Li Chen, Maolun Liu, Han Yang, Shan Ren, Qiang Sun, Hui Zhao, Tianqi Ming, Shun Tang, Qiu Tao, Sha Zeng, Xianli Meng, Haibo Xu
Summary: It has been discovered that ursolic acid (UA), a compound found in medicinal herbs, has potent effects against colorectal cancer (CRC) by inhibiting non-canonical Hedgehog signaling. This study investigated the influence of UA on non-canonical Hedgehog signaling in CRC, and found that UA inhibited cell proliferation, induced apoptosis, and down-regulated signaling proteins in CRC cells. Furthermore, UA also improved symptoms, inhibited tumor growth, and induced apoptosis in a CRC xenograft model.
PHYTOTHERAPY RESEARCH
(2022)
Article
Cell Biology
Wanshuang Cao, Yuan Li, Hongliang Sun, Chenying Yang, Jianyun Zhu, Chunfeng Xie, Xiaoting Li, Jieshu Wu, Shanshan Geng, Lu Wang, Liangfei Sun, Guozhu Geng, Hongyu Han, Caiyun Zhong
Summary: The study found that apatinib effectively suppressed GCSC traits, including inhibiting tumorsphere formation and cell proliferation, reducing GCSC markers expression and CD133(+) cell number, and inducing apoptosis. Additionally, apatinib downregulated the SHH pathway activation, which was crucial for inhibiting GCSCs.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Spectroscopy
S. K. Pathak, R. Srivastava, A. K. Sachan, O. Prasad, L. Sinha, A. M. Asiri, M. Karabacak
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2015)
Review
Oncology
S. Trivedi, F. Concha-Benavente, R. M. Srivastava, H. B. Jie, S. P. Gibson, N. C. Schmitt, R. L. Ferris
ANNALS OF ONCOLOGY
(2015)
Article
Toxicology
Mahendra P. Kashyap, Abhishek K. Singh, Dharmendra K. Yadav, Maqsood A. Siddiqui, Ritesh K. Srivastava, Vishal Chaturvedi, Navneet Rai
ARCHIVES OF TOXICOLOGY
(2015)
Article
Oncology
Kavita Baghel, Hasan Raza Kazmi, Saloni Raj, Abhijit Chandra, Rajeshwar Nath Srivastava
ASIAN PACIFIC JOURNAL OF CANCER PREVENTION
(2014)
Article
Dentistry, Oral Surgery & Medicine
Karoon Agrawal, Rani Umul Khair Mulla, Rakesh Srivastava, Sunil Sharma
CLEFT PALATE-CRANIOFACIAL JOURNAL
(2014)
Article
Biophysics
Balwinder Kaur, Rajendra Srivastava
COLLOIDS AND SURFACES B-BIOINTERFACES
(2014)
Article
Chemistry, Multidisciplinary
Naresh Sahebrao Nagpure, Rashmi Srivastava, Ravindra Kumar, Basdeo Kushwaha, Satish Kumar Srivastava, Pavan Kumar, Anurag Dabas
DRUG AND CHEMICAL TOXICOLOGY
(2015)
Article
Medicine, Legal
Vineeta Saini, Rashmi Srivastava, Satya Narayan Shamal, Tej Bali Singh, Vinod Kumar, Pramod Kumar, Sunil Kumar Tripathi
INTERNATIONAL JOURNAL OF LEGAL MEDICINE
(2014)
Article
Nanoscience & Nanotechnology
K. Byagari, A. Shanavas, A. K. Rengan, G. C. Kundu, R. Srivastava
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2014)
Article
Neurosciences
Mahendra P. Kashyap, Vivek Kumar, Abhishek K. Singh, Vinay K. Tripathi, Sadaf Jahan, Ankita Pandey, Ritesh K. Srivastava, Vinay K. Khanna, Aditya B. Pant
MOLECULAR NEUROBIOLOGY
(2015)
Article
Neurosciences
Ghanshyam Upadhyay, Sharmila Shankar, Rakesh K. Srivastava
MOLECULAR NEUROBIOLOGY
(2015)
Review
Dentistry, Oral Surgery & Medicine
D. E. Peterson, R. Srivastava, R. V. Lalla
Article
Pediatrics
Sanjay Mahant, Ron Keren, Russell Localio, Xianqun Luan, Lihai Song, Samir S. Shah, Joel S. Tieder, Karen M. Wilson, Lisa Elden, Rajendu Srivastava
Article
Biochemistry & Molecular Biology
G. Mallesham, S. Balaiah, M. Ananth Reddy, B. Sridhar, Punita Singh, Ritu Srivastava, K. Bhanuprakash, V. Jayathirtha Rao
PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
(2014)
Article
Dermatology
Rajeshwar N. Srivastava, Mukesh K. Dwivedi, Amit K. Bhagat, Saloni Raj, Rajiv Agarwal, Abhijit Chandra
INTERNATIONAL WOUND JOURNAL
(2016)
Review
Oncology
Xinru Zhou, Yin Jia, Chuanbin Mao, Shanrong Liu
Summary: Small extracellular vesicles (sEVs), such as exosomes, have emerged as crucial targets for liquid biopsy and promising drug delivery vehicles in tumor progression. They can serve as biomarkers for tumor diagnosis and as drug carriers for cancer treatment.
Article
Oncology
Ruochan Chen, Ju Zhu, Xiao Zhong, Jie Li, Rui Kang, Daolin Tang
Summary: The interplay between autophagy and apoptosis plays a crucial role in tumorigenesis and cancer therapy, with HMGB1 serving as a key regulator in these processes.
Article
Oncology
Zongfu Pan, Xixuan Lu, Tong Xu, Jinming Chen, Lisha Bao, Ying Li, Yingying Gong, Yulu Che, Xiaozhou Zou, Zhuo Tan, Ping Huang, Minghua Ge
Summary: This study uncovered the emerging role of HN1 in promoting dedifferentiation of anaplastic thyroid cancer (ATC) cells. HN1 negatively regulated the thyroid differentiation markers and had an inhibitory effect on the transcriptional activation of CTCF, thereby influencing the chromatin accessibility of thyroid differentiation genes.
Article
Oncology
Yi Qin, Shengjun Xiong, Jun Ren, Gautam Sethi
Summary: Autophagy plays an important regulatory role in glioblastoma, and its dysregulation can lead to drug resistance and radioresistance. It also affects stem cell characteristics, overall growth, and metastasis. Therefore, autophagy is a promising target for glioblastoma therapy.
Article
Oncology
Katsuya Nagaoka, Xuewei Bai, Dan Liu, Kevin Cao, Joud Mulla, Chengcheng Ji, Hongze Chen, Muhammad Azhar Nisar, Amalia Bay, William Mueller, Grace Hildebrand, Jin-Song Gao, Shaolei Lu, Hiroko Setoyama, Yasuhito Tanaka, Jack R. Wands, Chiung-Kuei Huang
Summary: This study found that serum 2-OG levels in cholangiocarcinoma patients are associated with the effectiveness of chemotherapy. Patients with progressive disease showed significantly higher levels of serum 2-OG compared to stable disease and partial response patients. The study also revealed that overexpression of ASPH mimics the effects of 2-OG, and knockdown of ASPH improves chemotherapy. Targeting ASPH enhances the effects of chemotherapy by modulating ATM and ATR, two key regulators of DDRs.