期刊
CANCER LETTERS
卷 335, 期 1, 页码 93-99出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2013.02.006
关键词
Sonodynamic therapy; 5-Aminolevulinic acid; Anti-angiogenesis; Anti-tumor
类别
资金
- National Natural Science Foundation of China [81272503]
- Scientific and Technical Key Tasks of Heilongjiang Province, China [GC10C306]
Studies of sonodynamic therapy (SDT) have mainly focused on its direct cytotoxic effect on tumor cells. Its effects on the tumor microenvironment, especially angiogenesis, remain unknown. In this study, we found that SDT significantly inhibited endothelial cell proliferation, migration, invasion, and tube formation. Furthermore, in a tumor xenograft mouse model, SDT was found to remarkably suppress tumor growth, intratumoral vascularity, and expression of vascular endothelial growth factor in tumor cells. An ultrastructural study showed damage and disruption of tumor microvasculature after STD. Our results indicate that SDT inhibits neovascularization in tumor, which is partially responsible for the anti-tumor effect of SDT. (c) 2013 Elsevier Ireland Ltd. All rights reserved.
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