Article
Oncology
Rackhyun Park, Yea-In Park, Yeonjeong Park, Siyun Lee, Jaeyeon So, Junsoo Park
Summary: CTRP1 plays a critical role in tumor progression, and knockout of CTRP1 gene can inhibit cell proliferation, invasion, and tumor growth. Elevated levels of CTRP1 are associated with poor prognosis.
Article
Immunology
Xiuyu Wei, Yongjie Yao, Xiaoxi Wang, Jiaxin Sun, Wenshan Zhao, Lu Qiu, Wenjie Zhai, Yuanming Qi, Yanfeng Gao, Yahong Wu
Summary: Colorectal cancer is one of the deadliest cancers, and the discovery of new diagnostic biomarkers and therapeutic targets is crucial. IL-36 alpha was found to be downregulated in human CRC tissues, and high levels of IL-36 alpha were associated with better survival rates. Overexpression of IL-36 alpha inhibited the proliferation, migration, and invasion of cancer cells and promoted the activation, proliferation, and infiltration of T lymphocytes. These results suggest that IL-36 alpha could be a promising therapeutic agent for targeting CRC.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Bojan Stojanovic, Nevena Gajovic, Milena Jurisevic, Milica Dimitrijevic Stojanovic, Marina Jovanovic, Ivan Jovanovic, Bojana S. Stojanovic, Bojan Milosevic
Summary: IL-33 plays a critical role in breast cancer biology, influencing cancer progression and immune response, and may serve as a therapeutic target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Robiya Joseph, Rama Soundararajan, Suhas Vasaikar, Fei Yang, Kendra L. Allton, Lin Tian, Petra den Hollander, Sevinj Isgandarova, Monika Haemmerle, Barbara Mino, Tieling Zhou, Crystal Shin, Melisa Martinez-Paniagua, Aysegul A. Sahin, Jaime Rodriguez-Canales, Juri Gelovani, Jeffrey T. Chang, Ghanashyam Acharya, Anil K. Sood, Ignacio I. Wistuba, Don L. Gibbons, Luisa M. Solis, Michelle C. Barton, Navin Varadarajan, Jeffrey M. Rosen, Xiang H. Zhang, Sendurai A. Mani
Summary: We found that immune infiltration within tumors differs between metastatic and non-metastatic tumors. Non-metastatic tumors have high levels of CD8(+) T cells and low levels of platelets, whereas this is reversed in metastatic tumors. Platelets and CXCL4 induce differentiation of monocytes into myeloid-derived suppressor cells (MDSCs) during tumor progression, inhibiting the function of CD8(+) T cells. TCGA data confirmed that patients with low CD8 levels and high platelet levels have lower survival probabilities compared to patients with high CD8 levels and low platelet levels.
BRITISH JOURNAL OF CANCER
(2021)
Article
Oncology
Demi Brownlie, Andreas von Kries, Giampiero Valenzano, Nicole Wild, Emel Yilmaz, Jesper Safholm, Mamdoh Al-Ameri, Evren Alici, Hans-Gustaf Ljunggren, Igor Schliemann, Ozan Aricak, Felix Haglund de Flon, Jakob Michaelsson, Nicole Marquardt
Summary: Lung cancer is a major cause of cancer-related deaths globally. High-parameter flow cytometry revealed the accumulation of tissue-resident lymphocytes, including trNK cells and CD8(+) T-RM cells, towards the center of human NSCLC. Unlike CD8(+) T-RM cells, trNK cells and ILCs generally expressed low levels of immune checkpoint receptors, and expressed high levels of granzyme, indicating their functional relevance in lung tumors.
Article
Multidisciplinary Sciences
Thomas Walle, Joscha A. Kraske, Boyu Liao, Benedicte Lenoir, Carmen Timke, Emilia von Bohlen Und Halbach, Florian Tran, Paul Griebel, Dorothee Albrecht, Azaz Ahmed, Meggy Suarez-Carmona, Alejandro Jimenez-Sanchez, Tizian Beikert, Alexandra Tietz-Dahlfuss, Ayse Nur Menevse, Gabriele Schmidt, Manuela Brom, Jens H. W. Pahl, Wiebke Antonopoulos, Matthias Miller, Ramon Lopez Perez, Felix Bestvater, Nathalia A. Giese, Philipp Beckhove, Philip Rosenstiel, Dirk Jaeger, Oliver Strobel, Dana Pe'er, Niels Halama, Juergen Debus, Adelheid Cerwenka, Peter E. Huber
Summary: NK cells play a central role in the radiation-induced immune response, enhancing tumor control through the secretion of CXCL8/IL-8 and recruiting immune cells. This discovery suggests a rational cancer treatment strategy combining NK cells with radiotherapy.
Review
Immunology
Xuewen Deng, Hiroshi Terunuma
Summary: Tumor immunotherapy has shown remarkable results in tumor treatment, but its effectiveness is limited in patients with low or absent pre-existing T cell immunity. Natural killer (NK) cells play a crucial role in preventing metastasis by eliminating highly motile circulating tumor cells (CTCs). Harnessing the power of NK cells against tumor metastasis is a promising approach.
Article
Medicine, Research & Experimental
Federico Perdomo-Celis, Caroline Passaes, Valerie Monceaux, Stevenn Volant, Faroudy Boufassa, Pierre de Truchis, Morgane Marcou, Katia Bourdic, Laurence Weiss, Corinne Jung, Christine Bourgeois, Cecile Goujard, Laurence Meyer, Michaela Muller-Trutwin, Olivier Lambotte, Asier Saez-Cirion
Summary: Virus-specific CD8(+) T cells play a central role in HIV-1 control and can be reprogrammed to enhance their antiviral potential through targeting specific signaling pathways.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Oncology
Yi Li, Hui Dong, Yudi Dong, Qiaoyuan Wu, Ni Jiang, Qing Luo, Fang Chen
Summary: The study found a correlation between the expression of CD8 T cells and NK cells in NPC and recurrence and metastasis, with high expression being favorable for patient survival.
CANCER MANAGEMENT AND RESEARCH
(2022)
Article
Cell Biology
Zheng Cao, Duo Xu, Jeffrey Harding, Wenting Chen, Xiangsheng Liu, Zi Wang, Lan Wang, Tong Qi, Shilin Chen, Xinheng Guo, Irvin S. Y. Chen, Jimin Guo, Yunfeng Lu, Jing Wen
Summary: Cancer immunotherapy is limited by tumor immunosuppression caused by excessive lactate production. This study presents a nanocapsule enzyme therapeutic approach based on lactate oxidase, which reduces lactate levels and releases immunostimulatory hydrogen peroxide, improving the efficacy of immune checkpoint blockade treatment.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Immunology
Grainne Jameson, Cathal Harmon, Rhyla Mae Santiago, Diarmaid D. Houlihan, Tom K. Gallagher, Lydia Lynch, Mark W. Robinson, Cliona O'Farrelly
Summary: Liver-resident CD56(bright)CD16(-) natural killer (NK) cells may contribute to immune tolerance during liver transplantation. RNA sequencing revealed that these liver-resident NK cells upregulated genes associated tissue residency and expressed immune receptors capable of activating NK cells. Functional assays demonstrated that hepatic NK cells had cytotoxic effects on allogenic CD8(+) T cells, with CD8(+) T cells being more susceptible than CD4(+) T cells, and this cytotoxic response could be enhanced by an anti-CD160 agonist.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Virginie Feliu, Carlos Gomez-Roca, Marie Michelas, Noemie Thebault, Francoise Lauzeral-Vizcaino, Anna Salvioni, Lise Scandella, Emeline Sarot, Carine Valle, Camille-Charlotte Balanca, Clara-Maria Scarlata, Jean-Pierre Delord, Maha Ayyoub, Christel Devaud
Summary: Despite the high prognostic value of immune infiltrates in colorectal cancer (CRC), metastatic disease remains resistant to immunotherapy by immune checkpoint blockade (ICB). Here, we show, in metastatic CRC preclinical models, that orthotopically implanted primary colon tumors exert a colon-specific antimetastatic effect on distant hepatic lesions. Enterotropic alpha 4 beta 7 integrin-expressing neoantigen-specific CD8 T cells were key components of the antimetastatic effect. Our findings identify a systemic cancer immunosurveillance role for gut-primed tumor-specific alpha 4 beta 7+ CD8 T cells.
SCIENCE IMMUNOLOGY
(2023)
Article
Immunology
Fei Tang, Qin Zhong, Zirong Yang, Hang Li, Cong Pan, Limin Huang, Tingting Ni, Rong Deng, Zi Wang, Shisheng Tan, Yingjie Nie, Yu Zhang
Summary: Combining low-dose CTX with IL-2 in anti-tumor treatment can significantly inhibit tumor growth by inhibiting tumor cell proliferation and increasing apoptosis, as well as increasing the infiltration of CD8(+) T cells.
Article
Multidisciplinary Sciences
Miho Akimoto, Takao Susa, Noriyuki Okudaira, Nobuko Koshikawa, Harumi Hisaki, Masayoshi Iizuka, Hiroko Okinaga, Keizo Takenaga, Tomoki Okazaki, Mimi Tamamori-Adachi
Summary: As a decoy receptor, soluble ST2 (sST2) interferes with the function of IL-33 and decreased sST2 expression in CRC cells promotes tumor growth. Hypoxia reduces sST2 expression and restoration of sST2 in hypoxic tumor regions corrects the inflammatory microenvironment and suppresses tumor growth and lung metastasis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biochemistry & Molecular Biology
Elizabeta Georgieva, Stefan L. Leber, Cora Wex, Christoph Garbers
Summary: The study reveals that perturbation of the actin cytoskeleton is not sufficient to induce NF-kappa B activation and IL-6 secretion, but it reduces IL-6-induced activation of STAT3 in Hep3B cells. Additionally, IL-6 receptor proteolysis by ADAM10 is not dependent on the integrity of the actin cytoskeleton.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Xinru Zhou, Yin Jia, Chuanbin Mao, Shanrong Liu
Summary: Small extracellular vesicles (sEVs), such as exosomes, have emerged as crucial targets for liquid biopsy and promising drug delivery vehicles in tumor progression. They can serve as biomarkers for tumor diagnosis and as drug carriers for cancer treatment.
Article
Oncology
Ruochan Chen, Ju Zhu, Xiao Zhong, Jie Li, Rui Kang, Daolin Tang
Summary: The interplay between autophagy and apoptosis plays a crucial role in tumorigenesis and cancer therapy, with HMGB1 serving as a key regulator in these processes.
Article
Oncology
Zongfu Pan, Xixuan Lu, Tong Xu, Jinming Chen, Lisha Bao, Ying Li, Yingying Gong, Yulu Che, Xiaozhou Zou, Zhuo Tan, Ping Huang, Minghua Ge
Summary: This study uncovered the emerging role of HN1 in promoting dedifferentiation of anaplastic thyroid cancer (ATC) cells. HN1 negatively regulated the thyroid differentiation markers and had an inhibitory effect on the transcriptional activation of CTCF, thereby influencing the chromatin accessibility of thyroid differentiation genes.
Article
Oncology
Yi Qin, Shengjun Xiong, Jun Ren, Gautam Sethi
Summary: Autophagy plays an important regulatory role in glioblastoma, and its dysregulation can lead to drug resistance and radioresistance. It also affects stem cell characteristics, overall growth, and metastasis. Therefore, autophagy is a promising target for glioblastoma therapy.
Article
Oncology
Katsuya Nagaoka, Xuewei Bai, Dan Liu, Kevin Cao, Joud Mulla, Chengcheng Ji, Hongze Chen, Muhammad Azhar Nisar, Amalia Bay, William Mueller, Grace Hildebrand, Jin-Song Gao, Shaolei Lu, Hiroko Setoyama, Yasuhito Tanaka, Jack R. Wands, Chiung-Kuei Huang
Summary: This study found that serum 2-OG levels in cholangiocarcinoma patients are associated with the effectiveness of chemotherapy. Patients with progressive disease showed significantly higher levels of serum 2-OG compared to stable disease and partial response patients. The study also revealed that overexpression of ASPH mimics the effects of 2-OG, and knockdown of ASPH improves chemotherapy. Targeting ASPH enhances the effects of chemotherapy by modulating ATM and ATR, two key regulators of DDRs.