Review
Chemistry, Analytical
Albert Perez-Alcaraz, Francesc Borrull, Marta Calull, Carme Aguilar
Summary: The consumption of synthetic cathinones has been increasing in recent years due to its affordability and accessibility as an alternative to amphetamines. Developing procedures capable of detecting and monitoring their consumption is crucial, and urine has been widely used for this purpose as it is non-invasive and provides larger sample volumes than other biological matrices. Chromatographic techniques are the most reported approach for determining cathinones in urine samples.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Fangfang Zhu, Honglong Liu, Wenqing Zhang, Chuanyuan Du, Hao Zhu, Xiaodi Du, Xiaosong Hu, Yawei Lin
Summary: A novel BSMAD derivative was synthesized for the quantitative analysis of BAs in alcoholic beverages, and a HPLC method with low detection limit and excellent repeatability was successfully established. The method was applied for BA determination in various types of alcoholic beverages with satisfactory recoveries, providing a reliable and sensitive approach for future studies.
Review
Chemistry, Medicinal
Hussain Alessa, Amr L. Saber, Jalal T. Althakafy
Summary: This study aimed to summarize recent outcomes of chromatographic methods, such as gas chromatography and high-performance liquid chromatography, used for the determination of melatonin over the past three decades.
ARCHIV DER PHARMAZIE
(2022)
Review
Food Science & Technology
Huynh N. P. Dang, Joselito P. Quirino
Summary: Alkenylbenzenes are potentially toxic compounds found in food, especially in flavorings, requiring constant monitoring due to concerns about their health effects. The challenge in determining alkenylbenzenes in food lies in the complex sample matrices and low amounts present. Gas and liquid chromatography are commonly used separation techniques, with detection methods including flame ionisation and mass spectrometry.
Article
Engineering, Environmental
Luz A. Hernandez-Carabali, Rakesh Sachdeva, Jose B. Rojas-Trigos, Ernesto Marin, Carlos D. Garcia
Summary: In this study, a thin film of ZnO was grown and characterized to investigate its effect on the photo-chemical degradation of pharmaceuticals. The results showed that the film was able to efficiently degrade pharmaceutical compounds under relatively mild conditions and was applicable to other compounds with similar properties.
JOURNAL OF WATER PROCESS ENGINEERING
(2021)
Review
Chemistry, Multidisciplinary
Siyu Chen, Weibo Huang, Yunliang Qiu, Xueji Zhang, Jinming Kong
Summary: This paper describes the mechanism of action and drug metabolism process of flunitrazepam, reviews the different methods for detecting flunitrazepam published over the years, summarizes the detection limits of each method and compares their advantages and disadvantages. We hope to provide some inspiration for future research in this field.
Review
Chemistry, Analytical
Behrouz Seyfinejad, Abolghasem Jouyban
Summary: This review aims to provide a guide on establishing reliable TDM, critically review current analytical methods and clinical practices for ISD TDM, and discuss key practical aspects of TDM.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2021)
Review
Chemistry, Analytical
Apostolia Tsiasioti, Constantinos K. Zacharis, Paraskevas D. Tzanavaras
Summary: This article reviews recent studies on the determination of histamine in food matrices using derivatization-based separation methods. The derivatization of histamine plays an important role in enhancing sensitivity, selectivity, and compatibility to analytical techniques. The article also discusses the application of the latest derivatizing reagents for histamine and various analytical techniques.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Oumaima El Ouahabi, Montserrat Mancera-Arteu, Laura Pont, Estela Gimenez, Victoria Sanz-Nebot, Fernando Benavente
Summary: This study compared the analysis of opioid peptides using on-line solid-phase extraction capillary liquid chromatography-mass spectrometry (SPE-CapLC-MS) and on-line solid-phase extraction capillary electrophoresis-mass spectrometry (SPE-CE-MS). The SPE-CapLC-MS method showed improved detection limits and sensitivity compared to the CapLC-MS method. A comparison with the valve-free C18-SPE-CE-MS method revealed noticeable differences in operation and instrumental setup.
MICROCHEMICAL JOURNAL
(2022)
Article
Chemistry, Analytical
Yasin El Abiead, Christoph Bueschl, Lisa Panzenboeck, Mingxun Wang, Maria Doppler, Bernhard Seidl, Juergen Zanghellini, Pieter C. Dorrestein, Gunda Koellensperger
Summary: This study utilized 13C labeled and unlabeled Pichia pastoris extracts to identify heterogeneous multimerization in biological samples and successfully annotated the monomeric partners of these heteromers. Additionally, they created the first MS/MS library that included data from heteromultimers and demonstrated the relevance of these newly annotated ions to other publicly available datasets. Furthermore, their workflow detected metabolite features originating from heterodimers in other datasets as well.
ANALYTICA CHIMICA ACTA
(2022)
Article
Environmental Sciences
Oliver Hoecker, Dirk Flottmann, Torsten C. Schmidt, Christian Neusuess
Summary: This study investigates the factors influencing biomarker discovery in non-targeted analyses using liquid separation coupled to mass spectrometry. The results suggest that using different separation techniques and processing tools can improve the reproducibility of features, but the choice of mass spectrometer also significantly impacts comprehensive biomarker discovery.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Review
Chemistry, Analytical
Ines C. Santos, Jennifer S. Brodbelt
Summary: The development of new strategies for analyzing nucleic acids has gained momentum due to increased interest in using these biomolecules as drugs or drug targets. Application of new mass spectrometry ion activation techniques and optimization of separation methods have allowed more detailed characterization of nucleic acids and oligonucleotide therapeutics, leading to confirmation of sequence, localization of modifications and interaction sites, structural analysis, and identification of failed sequences and degradation products.
JOURNAL OF SEPARATION SCIENCE
(2021)
Article
Food Science & Technology
Natividad Jurado-Campos, Maria Garcia-Nicolas, Marta Pastor-Belda, Tom Bussmann, Natalia Arroyo-Manzanares, Brigida Jimenez, Pilar Vinas, Lourdes Arce
Summary: This study investigated the potential of using HS-UV-IMS for the untargeted volatile fingerprinting of organic and conventional olives, achieving a success rate of 94.39%. For olive oil samples, HS-GC-IMS and CE-UV techniques were employed for analysis, with CE-UV showing higher classification accuracy (95.76%) and more stability over time.
Review
Chemistry, Analytical
Justyna Piechocka, Rafal Glowacki
Summary: This overview summarizes all documented analytical methods for the quantification of homocysteine thiolactone (HTL) in biological samples, with a focus on pre-analytical treatment strategies and separation techniques. The review also discusses the advantages, pitfalls, and limitations of the methods, as well as the origin and main metabolites of HTL, and the association between civilization diseases and sulfur-containing compounds' metabolism disorders.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Gege Song, Zhiqiao Zou, Ailing Feng, Chenbiao Li, Meijuan Liang, Fuan Wang, Xiaoqing Liu
Summary: In this study, a flexible and portable light-up aptameric sensor was developed for smartphone-based point-of-care testing. By manipulating the affinity and dynamic response of designer DNA molecules, detection of serotonin was achieved with high sensitivity and selectivity. The study also demonstrated the versatility of the engineered aptameric molecular probes for different sensing applications.
ANALYTICAL CHEMISTRY
(2023)
Article
Physics, Atomic, Molecular & Chemical
Vaneet K. Sharma, Wennan Xiong, James Glick, Paul Vouros
EUROPEAN JOURNAL OF MASS SPECTROMETRY
(2014)
Article
Physics, Atomic, Molecular & Chemical
Vaneet K. Sharma, Paul Vouros, James Glick
INTERNATIONAL JOURNAL OF MASS SPECTROMETRY
(2011)
Article
Biochemical Research Methods
Vaneet K. Sharma, James Glick, Paul Vouros
JOURNAL OF CHROMATOGRAPHY A
(2012)
Article
Biochemical Research Methods
Vaneet K. Sharma, James Glick, Qing Liao, Chang Shen, Paul Vouros
JOURNAL OF MASS SPECTROMETRY
(2012)
Article
Nanoscience & Nanotechnology
Minhua Zhao, Vaneet Sharma, Haoyan Wei, Robert R. Birge, Jeffrey A. Stuart, Fotios Papadimitrakopoulos, Bryan D. Huey
Article
Immunology
Vaneet K. Sharma, Bijay Misra, Kevin T. McManus, Sreenivas Avula, Kaliappanadar Nellaiappan, Marina Caskey, Jill Horowitz, Michel C. Nussenzweig, Michael S. Seaman, Indu Javeri, Antu K. Dey
Article
Chemistry, Analytical
VK Sharma, JS Aulakh, AK Malik
Article
Agriculture, Multidisciplinary
AK Malik, V Sharma, VK Sharma
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2004)
Article
Chemistry, Analytical
VK Sharma, JS Aulakh, S Bansal, AK Malik, RK Mahajan
INTERNATIONAL JOURNAL OF ENVIRONMENTAL ANALYTICAL CHEMISTRY
(2004)
Review
Chemistry, Analytical
VK Sharma, JS Aulakh, AK Malik
JOURNAL OF ENVIRONMENTAL MONITORING
(2003)
Review
Oncology
Xinru Zhou, Yin Jia, Chuanbin Mao, Shanrong Liu
Summary: Small extracellular vesicles (sEVs), such as exosomes, have emerged as crucial targets for liquid biopsy and promising drug delivery vehicles in tumor progression. They can serve as biomarkers for tumor diagnosis and as drug carriers for cancer treatment.
Article
Oncology
Ruochan Chen, Ju Zhu, Xiao Zhong, Jie Li, Rui Kang, Daolin Tang
Summary: The interplay between autophagy and apoptosis plays a crucial role in tumorigenesis and cancer therapy, with HMGB1 serving as a key regulator in these processes.
Article
Oncology
Zongfu Pan, Xixuan Lu, Tong Xu, Jinming Chen, Lisha Bao, Ying Li, Yingying Gong, Yulu Che, Xiaozhou Zou, Zhuo Tan, Ping Huang, Minghua Ge
Summary: This study uncovered the emerging role of HN1 in promoting dedifferentiation of anaplastic thyroid cancer (ATC) cells. HN1 negatively regulated the thyroid differentiation markers and had an inhibitory effect on the transcriptional activation of CTCF, thereby influencing the chromatin accessibility of thyroid differentiation genes.
Article
Oncology
Yi Qin, Shengjun Xiong, Jun Ren, Gautam Sethi
Summary: Autophagy plays an important regulatory role in glioblastoma, and its dysregulation can lead to drug resistance and radioresistance. It also affects stem cell characteristics, overall growth, and metastasis. Therefore, autophagy is a promising target for glioblastoma therapy.
Article
Oncology
Katsuya Nagaoka, Xuewei Bai, Dan Liu, Kevin Cao, Joud Mulla, Chengcheng Ji, Hongze Chen, Muhammad Azhar Nisar, Amalia Bay, William Mueller, Grace Hildebrand, Jin-Song Gao, Shaolei Lu, Hiroko Setoyama, Yasuhito Tanaka, Jack R. Wands, Chiung-Kuei Huang
Summary: This study found that serum 2-OG levels in cholangiocarcinoma patients are associated with the effectiveness of chemotherapy. Patients with progressive disease showed significantly higher levels of serum 2-OG compared to stable disease and partial response patients. The study also revealed that overexpression of ASPH mimics the effects of 2-OG, and knockdown of ASPH improves chemotherapy. Targeting ASPH enhances the effects of chemotherapy by modulating ATM and ATR, two key regulators of DDRs.