☆ 4.7 Article

Mesenchymal and stem-like cell properties targeted in suppression of chronically-induced breast cell carcinogenesis

CANCER LETTERS (2013)

期刊

CANCER LETTERS

卷 333, 期 1, 页码 113-123

出版社

ELSEVIER IRELAND LTD

DOI: 10.1016/j.canlet.2013.01.030

关键词

Breast cell carcinogenesis; Cancer stem-like cells; Epithelial-to-mesenchymal transition; Intervention of carcinogenesis; Low-dose carcinogens

类别

Oncology

资金

University of Tennessee, College of Veterinary Medicine, Center of Excellence in Livestock Diseases and Human Health
National Institutes of Health [CA125795, CA129772]

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Protocol

Reagent

摘要

Stem-like cells and the epithelial-to-mesenchymal transition (EMT) program are postulated to play important roles in various stages of cancer development, but their roles in breast cell carcinogenesis and intervention remain to be clarified. We investigated stem-like cell- and EMT-associated properties and markers in breast epithelial cells chronically exposed to low-dose 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and benzo[a]pyrene in the presence and absence of the preventive agents green tea catechins and grape seed extract. Our results indicate that stem-like cell- and EMT-associated properties and markers should be seriously considered as new cancer-associated indicators for detecting breast cell carcinogenesis and as endpoints for intervention of carcinogenesis. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

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