P97/CDC-48: Proteostasis control in tumor cell biology

P97/CDC-48 is a prominent member of a highly evolutionary conserved Walker cassette - containing AAA + ATPases. It has been involved in numerous cellular processes ranging from the control of protein homeostasis to membrane trafficking through the intervention of specific accessory proteins. Expression of p97/CDC-48 in cancers has been correlated with tumor aggressiveness and prognosis, however the precise underlying molecular mechanisms remain to be characterized. Moreover p97/CDC-48 inhibitors were developed and are currently under intense investigation as anticancer drugs. Herein, we discuss the role of p97/CDC-48 in cancer development and its therapeutic potential in tumor cell biology. (C) 2013 Elsevier Ireland Ltd. All rights reserved.