期刊
CANCER LETTERS
卷 335, 期 2, 页码 455-462出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2013.03.003
关键词
MiR-145; HDAC2; Tumor suppressor; Liver cancer
类别
资金
- National Research Foundation of Korea (NRF)
- Ministry of Education, Science and Technology (MEST) [2011-0010705, 2012M3A9D1054476]
- Korean Science and Engineering Foundation via the Cancer Evolution Research Center at The Catholic University of Korea
- National Research Foundation of Korea [2012M3A9D1054510, 2011-0010705, 2012R1A5A2047939] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Aberrant regulation of histone deacetylase 2 (HDAC2) plays a pivotal role in the development of hepatocellular carcinoma (HCC), but, the underlying mechanism leading to HDAC2 overexpression is not well understood. We performed microRNA (miRNA) profiling analysis in a subset of HCCs, and identified four down-regulated miRNAs that may target HDAC2 in HCC. Ectopic expression of miRNA mimics evidenced that miR-145 suppresses HDAC2 expression in HCC cells. This treatment repressed cancer cell growth and recapitulated HDAC2 knockdown effects on HCC cells. In conclusion, we suggest that loss or suppression of miR-145 may cause aberrant overexpression of HDAC2 and promote HCC tumorigenesis. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
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