期刊
CANCER LETTERS
卷 333, 期 2, 页码 159-169出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2013.01.028
关键词
Angiogenesis; miR-503; FGF2; VEGFA; Methylation
类别
资金
- National Basic Research (973) Program [2013CB0531101]
- State Key Laboratory of Freshwater Ecology and Biotechnology [2011FB16]
- Fundamental Research Funds for the Central Universities [2010MS015]
- Key Academic Program Leader Award of Wuhan City [200951830560]
FGF2 and VEGFA are the two most potent angiogenic factors. Here we report that miR-503 can simultaneously down-regulate FGF2 and VEGFA. The expression of miR-503 is repressed in HCC cells and primary tumors due to a potential epigenetic mechanism. Overexpression of miR-503 reduced tumor angiogenesis in vitro and in vivo. We also found that miR-503 expression was down-regulated by hypoxia through HIFI or. These results identify a miRNA that targets both FGF2 and VEGFA in cancers, demonstrate the anti-angiogenesis role of miR-503 in tumorigenesis, and provide a novel mechanism for hypoxia-induced FGF2 and VEGFA through HIFI et-mediated inhibition of miR-503. Published by Elsevier Ireland Ltd.
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