期刊
CANCER LETTERS
卷 333, 期 1, 页码 9-17出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2012.11.056
关键词
Acute lymphoblastic leukemia; Bone marrow stromal cells; Wnt pathway; Wnt pathway inhibitor; Chemotherapy resistance
类别
资金
- American Cancer Society [119645-RSG-10-131-01-DDC]
- Physician Scientist Program Award from MD Anderson
- National Natural Science Foundation of China [81200385]
- China Scholarship Council
- High Level Health Technology Innovation of Elite Culture Program of Zhejiang Province
- MD Anderson Support Grant [CA016672]
Leukemia cells are protected by various components of their microenvironment, including marrow stromal cells (MSCs). To understand the molecular mechanisms underlying this protection, we cultured acute lymphoblastic leukemia (ALL) cells with MSCs and studied the effect of the latter on the molecular profiling of ALL cells at the mRNA and protein levels. Our results indicated that activated Wnt signaling in ALL cells is involved in MSC-mediated drug resistance. Blocking the Wnt pathway sensitized the leukemia cells to chemotherapy and improved overall survival in a mouse model. Targeting the Wnt pathway may be an innovative approach to the treatment of ALL. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据