期刊
CANCER LETTERS
卷 338, 期 1, 页码 101-109出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2012.05.001
关键词
Chemoresistance; HCC; Self-renewal; Tumor-initiating cells; Tumorigenicity
类别
资金
- Hong Kong Research Grants Council [HKU 7/CRF/09]
Hepatocellular carcinoma (HCC) is a common malignancy worldwide and has poor prognosis. Existing treatment modalities, including surgery, chemotherapy, and radiofrequency ablation, which target tumor bulk, have demonstrated limited therapeutic efficacy. In the past 10 years, accumulating evidence has supported the existence of cancer stem cells (CSCs) or tumor initiating cells (T-ICs) within tumors including HCC. Identification of liver T-ICs and the signaling pathways that they are involved in may shed light on novel therapeutic strategies against this deadly disease. In this review, we will discuss recent progresses made in the research of liver T-ICs with regard to identification, functional characterization, regulation and therapeutic implications. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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