期刊
CANCER LETTERS
卷 338, 期 2, 页码 300-316出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2013.06.011
关键词
Oral cancer; Minimal residual disease; Cancer stem cells; Side population; Multi-drug resistance; Tumorigenic potential
类别
资金
- Department of Biotechnology, Government of India [BT/PR/7793/MED/14/1112/2006]
- Council of Scientific and Industrial Research, Govt. of India [CSIR] [09/716(0079)/2006-EMR-I]
An in vitro cell line model was established to exemplify tumor stem cell concept in oral cancer. We were able to identify CD147 expressing fractions in SCC172 OSCC cell line with differing Hoechst dye efflux activity and DNA content. In vivo tumorigenic assay revealed three fractions enriched with stem-like cells capable of undergoing mesenchymal transition and a non-tumorigenic fraction. The regeneration potential and transition of one fraction to other imitated the phenotypic switch and functional disparities evidenced during oral tumor progression. Knowledge of these additional stem-like subsets will improve understanding of stem cell based oral epithelial tumor progression from normal to malignant lesions. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
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