Article
Endocrinology & Metabolism
Meng Wei, Fang Wang, Lihong Shang, Ting Hao, Chunfang Ha
Summary: This study found that NF-KBp65 is regulated by the RAS/MEK/ERK signaling pathway to promote the proliferation and invasion of endometrial stromal cells. These results provide multiple potential targets for non-hormonal therapy for endometriosis.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Article
Oncology
Hui-Huang Lai, Liang-Yi Hung, Chia-Jui Yen, Hsu-Chin Hung, Ruo-Yu Chen, Yu-Chao Ku, Hang-Tat Lo, Hung-Wen Tsai, Yun-Ping Lee, Tz-Hsuan Yang, Yen-Yu Chen, Yi-Shuian Huang, Wenya Huang
Summary: The overexpression of DNA repair gene NEIL3 in hepatocellular carcinoma (HCC) is associated with tumor development and metastasis. NEIL3 activates specific pathways to promote epithelial-mesenchymal transition, leading to tumor resistance and metastasis. This study suggests that NEIL3 may serve as a potential biomarker for predicting HCC recurrence and clinical intervention.
JOURNAL OF PATHOLOGY
(2022)
Article
Cell Biology
Dinesh Kumar, Saket Awadesbhai Patel, Md. Khurshidul Hassan, Nachiketa Mohapatra, Niharika Pattanaik, Manjusha Dixit
Summary: IQGAP2 functions as a tumor suppressor in breast cancer by enhancing apoptosis, reducing epithelial-mesenchymal transition, and negatively regulating oncogenic properties of breast cancer cells. The interaction between IQGAP1 and IQGAP2 suggests the possibility of IQGAP2 sequestering IQGAP1 to inhibit ERK activation. Targeting IQGAP2 could be a potential therapeutic intervention for breast cancer.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Huijun Cao, Zhiqiang Wang, Ying Wang, Lijuan Ye, Ruilei Li, Yuanbo Xue, Ke Li, Tiannan Di, Tao Li, Zonglin Fan, Yanyan Liu, Jiyin Guo, Hong Yao, Chunlei Ge
Summary: PPP1R14D is highly expressed in lung adenocarcinoma and its knockdown inhibits cancer cell proliferation, migration, and invasion by inactivating key signaling pathways and proteins. It may serve as a potential prognostic factor and therapeutic target in lung adenocarcinoma.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2022)
Article
Oncology
Shinsuke Fujii, Takuma Ishibashi, Megumi Kokura, Tatsufumi Fujimoto, Shinji Matsumoto, Satsuki Shidara, Kari J. Kurppa, Judith Pape, Javier Caton, Peter R. Morgan, Kristiina Heikinheimo, Akira Kikuchi, Eijiro Jimi, Tamotsu Kiyoshima
Summary: Ameloblastoma is a slow-growing odontogenic neoplasm with reported cases of successful treatment using a BRAF inhibitor. Recent research indicates a potential involvement of the MAPK pathway in Ameloblastoma development, with ARL4C expression possibly promoting tumorigenesis. Further investigation into the function of ARL4C in Ameloblastoma is needed.
JOURNAL OF PATHOLOGY
(2022)
Article
Nutrition & Dietetics
Jingya Lyu, Kensaku Fukunaga, Hitomi Imachi, Seisuke Sato, Toshihiro Kobayashi, Takanobu Saheki, Tomohiro Ibata, Takafumi Yoshimura, Hisakazu Iwama, Koji Murao
Summary: The study demonstrated that oxidized low-density lipoprotein (OxLDL) downregulates ABCA1 expression through the MEK/ERK/LXR pathway, leading to lipid accumulation in INS-1 cells, potentially resulting in impaired insulin synthesis and glucose-stimulated insulin secretion (GSIS).
Article
Biochemistry & Molecular Biology
Chuntian Huang, Ruijuan Du, Xuechao Jia, Kangdong Liu, Yan Qiao, Qiong Wu, Ning Yao, Lu Yang, Liting Zhou, Xuejiao Liu, Pu Xiang, Mingxia Xin, Yan Wang, Xiaojie Chen, Dong Joon Kim, Zigang Dong, Xiang Li
Summary: The study revealed that CDK15 plays a pivotal role in colorectal cancer progression by phosphorylating PAK4 to promote tumor growth. The CDK15-PAK4 axis may serve as a novel therapeutic target for colorectal cancer.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Plant Sciences
Xiao-Li Li, Xiu-Xiu Zhang, Run-Hui Ma, Zhi-Jing Ni, Kiran Thakur, Carlos L. Cespedes-Acuna, Jian-Guo Zhang, Zhao -Jun Wei
Summary: This study investigated the efficacy of PS on proliferation and migration of Endometrial carcinoma cells. Through experiments using xenograft model and Ishikawa cells, the potential molecular mechanism of dioscin was explored. The results showed that dioscin inhibited Ishikawa cell migration and invasion through the MEK/ERK and JNK signaling pathways. Hub miRNAs and genes identified in this study could be potential molecular targets for future EC treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Oncology
Li Han, Peiwu Li, Xu Fu, Zhenzhen Huang, Wen Yin
Summary: This study investigates the anti-tumor effects of Aesculetin (AE), a natural coumarin derivative, on bladder cancer cells and its molecular mechanisms. AE inhibited the proliferation of bladder cancer cells and induced apoptosis through the activation of the MEK/ERK pathway. These findings suggest potential therapeutic strategies for bladder cancer.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2023)
Article
Neurosciences
Yishan Huang, Pei Liu, Juanjuan Luo, Chenchen Zhu, Chunjiao Lu, Na Zhao, Weijiang Zhao, Wei Cui, Xiaojun Yang
Summary: The invasion of glioblastoma leads to poor prognosis in patients with glioma. The study demonstrates that high expression of Par6 is positively correlated with malignancy and poor prognosis of glioma patients. Par6 overexpression enhances glioma invasion by activating the MEK/ERK/STAT3 signaling pathway, and the LIN28/let-7d axis is involved in this process.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Wenwen Zhang, Meihua Liu, Yurou Ji, Dake Yu, Chuanrui Ma, Jianguo Zhao, Pengpeng Qu
Summary: This study aimed to determine the antitumor activity of tanshinone IIA against endometrial carcinoma and investigate the associated molecular mechanism. Results showed that tanshinone IIA inhibited tumor growth by inducing apoptosis and inhibiting migration through upregulating TRIB3 expression and inhibiting the MAPK/ERK signaling pathway. In addition, tanshinone IIA induced TRIB3 expression in vivo, further inhibiting tumor growth. In conclusion, tanshinone IIA has significant antitumor effects and can be used as a drug for endometrial carcinoma treatment.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2023)
Article
Obstetrics & Gynecology
Meng Xing, Bin'e Wu, Shuxia Wang
Summary: This study investigated the role and mechanism of action of Heat shock protein B7 (HSPB7) in endometrial carcinoma (EC). The results showed that HSPB7 was downregulated in EC and influenced EC cell proliferation, invasion, migration, and apoptosis via the PI3K/AKT/mTOR signaling pathway. These findings provide a novel perspective for the development of EC treatment strategies.
REPRODUCTIVE SCIENCES
(2023)
Article
Integrative & Complementary Medicine
Lianhai Zhang, Wei Shao
Summary: miR-143-3p is downregulated in Wilms' tumor and its expression is closely associated with tumor stage and lymph node metastasis. Overexpression of miR-143-3p inhibits cell proliferation through cell cycle arrest and induction of apoptosis. Moreover, miR-143-3p directly targets k-Ras, and increased expression of k-Ras is inversely correlated with miR-143-3p. These findings suggest that miR-143-3p may serve as a potential prognostic biomarker and therapeutic target for Wilms' tumor.
ALTERNATIVE THERAPIES IN HEALTH AND MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Zhun Wei, Kezhou Xia, Bin Zhou, Di Zheng, Weichun Guo
Summary: This research indicates that ZYX protein plays a role in the biological behavior of osteosarcoma cells. Higher expression of ZYX is associated with better outcomes in patients. The study also reveals that ZYX inhibits osteosarcoma cell proliferation, migration, and invasion through the regulation of the Rap1/MEK/ERK signaling pathway.
Article
Food Science & Technology
Fan Zhang, Zhi-Jing Ni, Lei Ye, Yuan-Yuan Zhang, Kiran Thakur, Carlos L. Cespedes-Acuna, Jinzhi Han, Jian-Guo Zhang, Zhao-Jun Wei
Summary: The study elucidated the anti-metastasis mechanism of Asparanin A on Ishikawa cells, showing that AA could suppress human EC cell migration and invasion through the Ras/ERK/MAPK pathway based on miRNA-seq and mRNA-seq integrated analyses.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Obstetrics & Gynecology
Fei Teng, Yan-Fang Zhang, Ying-Mei Wang, Jing Yu, Xu Lang, Wen-Yan Tian, Chang-Xin Jiang, Feng-Xia Xue
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2015)
Article
Obstetrics & Gynecology
Nv Geng, Wenjuan Wu, Aiping Fan, Cha Han, Chen Wang, Yingmei Wang, Fengxia Xue
GYNECOLOGIC AND OBSTETRIC INVESTIGATION
(2016)
Article
Obstetrics & Gynecology
Cha Han, Chen Wang, Xiao-Juan Liu, Nv Geng, Ying-Mei Wang, Ai-Ping Fan, Bi-Bo Yuan, Feng-Xia Xue
TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY
(2015)
Article
Oncology
Yingmei Wang, Chao Gao, Yanfang Zhang, Jinping Gao, Fei Teng, Wenyan Tian, Wen Yang, Ye Yan, Fengxia Xue
GYNECOLOGIC ONCOLOGY
(2016)
Article
Obstetrics & Gynecology
Yingmei Wang, Cha Han, Fei Teng, Zhaoyi Bai, Wenyan Tian, Fengxia Xue
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2017)
Article
Oncology
Yingmei Wang, Limei Hu, Ping Ji, Fei Teng, Wenyan Tian, Yuexin Liu, David Cogdell, Jinsong Liu, Anil K. Sood, Russell Broaddus, Fengxia Xue, Wei Zhang
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2016)
Article
Oncology
Fei Teng, Wen-Yan Tian, Ying-Mei Wang, Yan-Fang Zhang, Fei Guo, Jing Zhao, Chao Gao, Feng-Xia Xue
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2016)
Article
Obstetrics & Gynecology
Guoyan Liu, Qianwen Li, Xiaobin Shang, Zheng Qi, Cha Han, Yingmei Wang, Fengxia Xue
JOURNAL OF LOWER GENITAL TRACT DISEASE
(2016)
Article
Obstetrics & Gynecology
Yingmei Wang, Yufang Yang, Fei Teng, Huiying Zhang, Fengxia Xue
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2014)
Review
Obstetrics & Gynecology
Cha Han, Wenjuan Wu, Aiping Fan, Yingmei Wang, Huiying Zhang, Zanjun Chu, Chen Wang, Fengxia Xue
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2015)
Review
Oncology
Chao Gao, Yingmei Wang, Wenyan Tian, Yuanxi Zhu, Fengxia Xue
GYNECOLOGIC ONCOLOGY
(2014)
Article
Endocrinology & Metabolism
Guoyan Liu, Yingmei Wang, Xuhong Zhang, Bibo Yuan, Cha Han, Fengxia Xue
GYNECOLOGICAL ENDOCRINOLOGY
(2014)
Article
Obstetrics & Gynecology
Xuegong Ma, Yingmei Wang, Hongna Sheng, Wenyan Tian, Zheng Qi, Fei Teng, Fengxia Xue
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2014)
Letter
Obstetrics & Gynecology
Xue Gong Ma, Ying Mei Wang, Feng Xia Xue
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2014)
Article
Oncology
Jinping Gao, Jintian Zhang, Wenyan Tian, Fei Teng, Huiying Zhang, Xuhong Zhang, Yingmei Wang, Fengxia Xue
CANCER BIOLOGY & THERAPY
(2017)
Review
Oncology
Xinru Zhou, Yin Jia, Chuanbin Mao, Shanrong Liu
Summary: Small extracellular vesicles (sEVs), such as exosomes, have emerged as crucial targets for liquid biopsy and promising drug delivery vehicles in tumor progression. They can serve as biomarkers for tumor diagnosis and as drug carriers for cancer treatment.
Article
Oncology
Ruochan Chen, Ju Zhu, Xiao Zhong, Jie Li, Rui Kang, Daolin Tang
Summary: The interplay between autophagy and apoptosis plays a crucial role in tumorigenesis and cancer therapy, with HMGB1 serving as a key regulator in these processes.
Article
Oncology
Zongfu Pan, Xixuan Lu, Tong Xu, Jinming Chen, Lisha Bao, Ying Li, Yingying Gong, Yulu Che, Xiaozhou Zou, Zhuo Tan, Ping Huang, Minghua Ge
Summary: This study uncovered the emerging role of HN1 in promoting dedifferentiation of anaplastic thyroid cancer (ATC) cells. HN1 negatively regulated the thyroid differentiation markers and had an inhibitory effect on the transcriptional activation of CTCF, thereby influencing the chromatin accessibility of thyroid differentiation genes.
Article
Oncology
Yi Qin, Shengjun Xiong, Jun Ren, Gautam Sethi
Summary: Autophagy plays an important regulatory role in glioblastoma, and its dysregulation can lead to drug resistance and radioresistance. It also affects stem cell characteristics, overall growth, and metastasis. Therefore, autophagy is a promising target for glioblastoma therapy.
Article
Oncology
Katsuya Nagaoka, Xuewei Bai, Dan Liu, Kevin Cao, Joud Mulla, Chengcheng Ji, Hongze Chen, Muhammad Azhar Nisar, Amalia Bay, William Mueller, Grace Hildebrand, Jin-Song Gao, Shaolei Lu, Hiroko Setoyama, Yasuhito Tanaka, Jack R. Wands, Chiung-Kuei Huang
Summary: This study found that serum 2-OG levels in cholangiocarcinoma patients are associated with the effectiveness of chemotherapy. Patients with progressive disease showed significantly higher levels of serum 2-OG compared to stable disease and partial response patients. The study also revealed that overexpression of ASPH mimics the effects of 2-OG, and knockdown of ASPH improves chemotherapy. Targeting ASPH enhances the effects of chemotherapy by modulating ATM and ATR, two key regulators of DDRs.
