期刊
CANCER LETTERS
卷 315, 期 1, 页码 86-95出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2011.10.016
关键词
CCN1 (CYR61); Apoptosis; Carboplatin; NF-kappa B; PI3K/Akt; Ovarian carcinoma cells
类别
资金
- National Cancer Center, Korea [NCC-0910262-3]
CYR61 over-expression promotes cell proliferation by inhibiting carboplatin-induced apoptosis, decreasing Bax expression, and increasing Bcl-xL, Mcl-1, and Bcl-2. At the same time, down-regulating p53 expression, while up-regulated NF-kappa B expression. Additionally, p21 and p53 promoter activities were reduced, while NF-kappa B and Bcl-2 activities increased. In parallel, CYR61-expressing cells, during carboplatin-induced apoptosis, resulted in an increase of Akt phosphorylation, while rapamycin-treated cells were not affected. Carboplatin effectively inhibited the activation of mTOR signaling cascade, which includes mTOR, 4E-BP1, p70S6K, HIF-1 alpha, and VEGF. These results provide evidence that CYR61 promotes cell proliferation and inhibits apoptosis. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
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