期刊
CANCER LETTERS
卷 323, 期 2, 页码 180-187出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2012.04.009
关键词
Autophagy; ER stress; BH3 mimetic; Bcl-2
类别
资金
- Natural Science Foundation of Jilin Provincial Science and Technology Department [201015240]
- National Natural Science Foundation of China [30801354, 30970791, 81141099]
Previous results showed that a novel BH3 mimetic S1 could induce cell death in a wide range of cancer types in vitro through Bax/Bak-dependent apoptosis. We demonstrated that in addition to mitochondrial pathway apoptosis, endoplasmic reticulum (ER) stress-associated apoptosis was also induced by Si. Moreover, S1 can induce autophagy in U251 cells, which may occur through ER stress and disruption of the association of Bcl-2 and Beclin 1. Inhibition of autophagy by the autophagic inhibitors 3-methyladenine (3-MA) or chloroquine (CQ) increased S1-induced apoptosis. In conclusion, autophagy plays an important role in S1-induced U251 cell death. (c) 2012 Elsevier Ireland Ltd. All rights reserved.
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