Article
Engineering, Biomedical
Deborah D. Chin, Neil Patel, Woori Lee, Sonali Kanaya, Jackson Cook, Eun Ji Chung
Summary: Atherosclerosis is a chronic inflammatory disease characterized by lipid-rich plaques in the arterial walls. Statin therapy is commonly used, but many patients still experience acute events. This study evaluated the long-term efficacy of miR-145 micelles, which showed sustained effects for up to two months in reducing plaque size and transdifferentiation in mice. These findings provide potential alternative therapies for chronic atherosclerosis patients.
BIOACTIVE MATERIALS
(2023)
Review
Pharmacology & Pharmacy
Davor Nestic, Ksenija Bozinovic, Isabela Pehar, Rebecca Wallace, Alan L. Parker, Dragomira Majhen
Summary: Adenoviruses have versatile therapeutic applications, from gene therapy to cancer treatment. Understanding the factors involved in adenovirus cell binding, entry, and trafficking, and how these factors can be manipulated to enhance the efficacy of adenovirus-based vectors, is crucial for optimizing gene therapy and vaccine development.
Article
Oncology
Qiujian Zhang, Zhe Cheng, Lei Shi, Gengsheng Mao
Summary: In gliomas, miR-145-5p inhibits the proliferation of GSCs and promotes apoptosis by suppressing the expression of TCTP. Therefore, miR-145-5p may serve as a novel therapeutic target for gliomas.
Article
Medicine, Research & Experimental
Jing Qian, Mo Yang, Qiang Feng, Xin-Yan Pan, Li-Lin Yang, Ju-Lun Yang
Summary: The study demonstrated that recombinant adenovirus KGHV500 delivered via CIK cells can effectively target Ras-driven gliomas, exhibiting anti-tumor activity and promising therapeutic potential.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2021)
Review
Chemistry, Medicinal
Dulce Mata-Espinosa, Jacqueline V. Lara-Espinosa, Jorge Barrios-Payan, Rogelio Hernandez-Pando
Summary: This study reviews the model strategies for gene therapy and new vaccines in the treatment of tuberculosis, suggesting that it is a potential alternative therapy for active TB, as well as for the prevention and treatment of latent TB reactivation and transmission of Mtb.
Article
Oncology
Estefania Contreras-Sanzon, Angeles Carlos-Reyes, Monica Sierra-Martinez, Gustavo Acosta-Altamirano, Cesar Luna-Rivero, David Nunez-Corona, Alejandra Paola Garcia-Hernandez, Eloisa Ibarra-Sierra, Horacio Vidrio-Morgado, Maria Elizbeth Alvarez-Sanchez, Laurence A. Marchat, Cesar Lopez-Camarillo
Summary: This study evaluated the expression of VM-associated microRNAs in tumors of metastatic breast cancer patients and explored their potential therapeutic value in disease progression. It was found that certain microRNAs regulating VM and metastasis were downregulated in primary tumors of patients with metastatic disease, and these regulatory factors had predictive value in patient survival. Furthermore, in vitro experiments demonstrated that miR-145 mimics could inhibit the development of VM in metastatic breast cancer cells.
TRANSLATIONAL ONCOLOGY
(2023)
Article
Oncology
Jinpeng Hu, Guoqing Zhang, Yongfeng Wang, Kai Xu, Lian Chen, Gang Luo, Jinkun Xu, Hao Li, Dongmei Pei, Xiang Zhao, Zhengting Guo, Xinqiao Li, Shengliang Zong, Yang Jiang, Zhitao Jing
Summary: This study identifies a novel circular RNA, circGNB1, which is upregulated in glioma and closely associated with poor prognosis. Functional assays reveal that circGNB1 overexpression promotes the viability, proliferation, invasion, and neurosphere formation of glioma stem cells. Mechanistically, circGNB1 upregulates the expression of oncogene XPR1 by sponging miR-515-5p and miR-582-3p. XPR1, in turn, promotes the malignant phenotype of glioma stem cells through upregulating IL6 expression and activating JAK2/STAT3 signaling. Additionally, the RNA binding protein IGF2BP3 binds to and stabilizes circGNB1, thus enhancing its effects on glioma stem cells. This study uncovers the crucial role of circGNB1 in tumorigenesis and malignant progression of glioma, providing a promising cancer biomarker.
CANCER CELL INTERNATIONAL
(2023)
Article
Oncology
Amanda Rosewell Shaw, Caroline Porter, Greyson Biegert, Lisa Jatta, Masataka Suzuki
Summary: Solid tumors are highly immunosuppressive and require simultaneous targeting of multiple inhibitory mechanisms for successful cancer immunotherapy. Adenoviral vectors have the ability to stimulate multiple immune pathways and are promising cancer gene therapy vectors. Helper-dependent adenoviral vectors can express multiple transgenes for immunomodulation in tumors.
Article
Medicine, Research & Experimental
Ignacio Fernando Hall, Montserrat Climent, Chiara Viviani Anselmi, Laura Papa, Vinicius Tragante, Luca Lambroia, Floriana Maria Farina, Marcus E. Kleber, Winfried Maerz, Carlo Biguori, Gianluigi Condorelli, Leonardo Elia
Summary: The study identifies a SNP, rs41291957 (A), near the miR-143/145 cluster that upregulates miR-143 and miR-145, modulating vascular smooth cell phenotype and acting as a protective factor against coronary artery disease.
EMBO MOLECULAR MEDICINE
(2021)
Article
Multidisciplinary Sciences
Sheena N. Smith, Rajib Schubert, Branko Simic, Dominik Brucher, Markus Schmid, Niels Kirk, Patrick C. Freitag, Viviana Gradinaru, Andreas Pluckthun
Summary: The research introduces a novel gene therapy platform that enables localized treatment within tumors, increasing both the specificity of antibody transduction and the production of antibodies. It demonstrates that this approach significantly reduces the systemic toxicity of drugs while enhancing therapeutic efficacy.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Elizabeth Wei-Chia Luo, Meng-Lin Liao, Chung-Liang Chien
Summary: GFAP-promoter controlled U251 stable clone showed GCV sensitivity, while neuronal N2A clones were nonreactive. During GCV treatment, cells underwent apoptosis on day 3 and dying cells were identified after day 5. Nestin was increasingly expressed in surviving cells, indicating enrichment of neural stem-like cells. Lower levels of GFAP expression were detected in surviving cells. Furthermore, beta III-tubulin-positive neuron-like cells were identified after GCV treatment.
Article
Biochemistry & Molecular Biology
Eduarda O. Z. Minin, Layde R. Paim, Elisangela C. P. Lopes, Larissa C. M. Bueno, Luis F. R. S. Carvalho-Romano, Edmilson R. Marques, Camila F. L. Vegian, Jose A. Pio-Magalhaes, Otavio R. Coelho-Filho, Andrei C. Sposito, Jose R. Matos-Souza, Wilson Nadruz, Roberto Schreiber
Summary: In this study, hypertensive patients with carotid plaques were found to have increased expression of miR-145-5p and miR-let7c, suggesting a potential role of these miRNAs as biomarkers for subclinical atherosclerosis in hypertensive individuals.
Article
Virology
Emily A. Bates, John R. Counsell, Sophie Alizert, Alexander T. Baker, Natalie Suff, Ashley Boyle, Angela C. Bradshaw, Simon N. Waddington, Stuart A. Nicklin, Andrew H. Baker, Alan L. Parker
Summary: Species D adenoviruses, such as human adenovirus type 49 (HAdV-D49), show promise for gene therapy applications due to their low pre-existing immunity rates. HAdV-D49 exhibits a broad range of cell transduction capabilities and interacts with various surface molecules for cell entry. Additionally, compared to adenovirus type 5, HAdV-D49 vectors demonstrate reduced liver targeting but maintain transduction of lung and spleen tissues.
Review
Biochemistry & Molecular Biology
Ranmal Avinash Bandara, Ziyan Rachel Chen, Jim Hu
Summary: The use of CRISPR/Cas9 in gene therapy for CF has shown great potential, but challenges remain in delivering and achieving efficiency in vivo, especially for lung gene therapy. Utilizing HD-Ad vectors to deliver CRISPR/Cas9 for lung gene therapy presents a new avenue for overcoming these challenges and holds promise for future treatments.
CELL AND BIOSCIENCE
(2021)
Article
Pharmacology & Pharmacy
Jessica Gambardella, Urna Kansakar, Celestino Sardu, Vincenzo Messina, Stanislovas S. Jankauskas, Raffaele Marfella, Paolo Maggi, Xujun Wang, Pasquale Mone, Giuseppe Paolisso, Daniela Sorriento, Gaetano Santulli
Summary: We hypothesized that exosomal microRNAs may play a role in the development of thromboembolic complications in COVID-19. We isolated circulating exosomes from COVID-19 patients and categorized them based on D-dimer levels. We found that exosomal miR-145 and miR-885 were significantly correlated with D-dimer levels. Furthermore, human endothelial cells treated with serum from COVID-19 patients showed reduced release of miR-145 and miR-885, increased apoptosis, and impaired angiogenetic properties compared to cells treated with non-COVID-19 serum.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2023)
Article
Medicine, Research & Experimental
Hyunhee Kim, Ka Young Lim, Jin Woo Park, Jeongwan Kang, Jae Kyung Won, Kwanghoon Lee, Yumi Shim, Chul-Kee Park, Seung-Ki Kim, Seung-Hong Choi, Tae Min Kim, Hongseok Yun, Sung-Hye Park
Summary: Mismatch repair-deficient brain tumors are rare and can be induced by mutations. This study examined 13 MMRD-associated brain tumors to determine their molecular characteristics and biological behavior. The tumors had high mutational burdens, varying genetic profiles, and some sensitivity to immunotherapy but resistance to certain drugs.
LABORATORY INVESTIGATION
(2022)
Article
Oncology
Enkhjin Saruuldalai, Jiyoung Park, Dongmin Kang, Seung-Phil Shin, Wonkyun Ronny Im, Hwi-Ho Lee, Jiyoung Joan Jang, Jong-Lyul Park, Seon-Young Kim, Jung-Ah Hwang, Young-Dong Kim, Jung-Hoon Lee, Eun Jung Park, Yeon-Su Lee, In-Hoo Kim, Sang-Jin Lee, Yong Sun Lee
Summary: This study discovered a novel mechanism of how a host non-coding RNA promotes adenoviral gene expression and replication, and suggested future possibilities of using nc886 to improve the efficacy of oncolytic adenovirus.
MOLECULAR THERAPY-ONCOLYTICS
(2022)
Article
Biology
Taeyoung Hwang, Sojin Kim, Tamrin Chowdhury, Hyeon Jong Yu, Kyung-Min Kim, Ho Kang, Jae-Kyung Won, Sung-Hye Park, Joo Heon Shin, Chul-Kee Park
Summary: The study reveals that Alu element-associated post-transcriptional processes and RNA expression are decreased in gliomas, with grade 2 oligodendrogliomas showing the least perturbation in A-to-I editing and circular RNA levels. This provides further insight into gliomagenesis from the perspective of Alu repeat elements.
COMMUNICATIONS BIOLOGY
(2022)
Article
Chemistry, Analytical
Youngwoong Kim, Jong Min An, Jaehoon Kim, Tamrin Chowdhury, Hyeon Jong Yu, Kyung-Min Kim, Ho Kang, Chul-Kee Park, Joonyoung F. Joung, Sungnam Park, Dokyoung Kim
Summary: This study developed a new fluorescent diagnostic probe with high selectivity and sensitivity for monitoring homocysteine. The probe showed rapid response and could predict the formation of glioblastoma at an early stage through sensing homocysteine in blood plasma.
ANALYTICA CHIMICA ACTA
(2022)
Article
Immunology
Seung-Phil Shin, Kwang-Soo Shin, Jeong-Mi Lee, In-Kyung Jung, Jimo Koo, Seung-Woo Lee, Seowoo Park, Jieun Shin, Myunghwan Park, Bongju Park, Hanseul Oh, Bon-Sang Koo, Jungjoo Hong, Choong-Min Ryu, Jae-Ouk Kim, Taegwon Oh, Chang-Yuil Kang
Summary: The study presents the development of AdCLD-CoV19 platform, which can boost humoral and cellular immunity with a single vaccination, effectively preventing SARS-CoV-2. The platform demonstrates the ability to neutralize various SARS-CoV-2 variants, and the neutralizing antibody activity can be restored through booster shots.
Article
Clinical Neurology
Ye Yoon Suh, Kwanghoon Lee, Yu-Mi Shim, Ji Hoon Phi, Chul-Kee Park, Seung-Ki Kim, Seung Hong Choi, Hongseok Yun, Sung-Hye Park
Summary: The MYB/MYBL1::QKI fusion activates the oncogene MYB and deletes the tumor suppressor gene QKI. Previously, this fusion was only reported in angiocentric glioma (AG) and diffuse low-grade glioma. This study compares two tumors with the MYB/MYBL1::QKI fusion: a diffuse pediatric-type high-grade glioma (DPedHGG) in an 11-year-old boy and an AG in a 46-year-old woman. Characterization using immunohistochemistry, next-generation sequencing, and methylation profiling reveals their molecular characteristics and supports the presence of MYB/MYBL1 alterations in higher-grade gliomas.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
(2023)
Article
Oncology
Jung Oh Lee, Sung Soo Ahn, Kyu Sung Choi, Junhyeok Lee, Joon Jang, Jung Hyun Park, Inpyeong Hwang, Chul-Kee Park, Sung Hye Park, Jin Wook Chung, Seung Hong Choi
Summary: This study investigated the prognostic value of spatial features from whole-brain MRI using a three-dimensional convolutional neural network for adult-type diffuse gliomas. The results showed that the MRI-based prognostic index model had good predictive performance, and combining clinical, molecular genetic, and imaging data improved the performance of the prediction model.
Article
Oncology
Jee Ye Kahng, Byung-Hee Kang, Soon-Tae Lee, Seung Hong Choi, Tae Min Kim, Chul-Kee Park, Jae-Kyung Won, Sung-Hye Park, Jaeman Son, Joo Ho Lee
Summary: This study investigated the relationship between neural stem cells (NSCs) in the subventricular zone (SVZ) and glioblastoma (GBM), as well as the impact of radiotherapeutic strategies. The results showed that GBM patients without SVZ involvement had longer progression-free survival, while patients with GBM in contact with NSCs showed better prognosis after NSC irradiation. This study is of great significance for understanding the origin and treatment of GBM.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Oncology
Seung Won Choi, Hyun Ae Jung, Hee-Jin Cho, Tae Min Kim, Chul-Kee Park, Do-Hyun Nam, Se-Hoon Lee
Summary: This study evaluated the therapeutic efficacy of the novel anti-EGFR monoclonal antibody GC1118 in recurrent GBM patients with EGFR amplification. Although the study did not meet the primary endpoint, it was found that immune-related signatures were significantly upregulated in tumors with regression upon GC1118 therapy, indicating the potential immune-mediated antitumor efficacy of GC1118.
Correction
Multidisciplinary Sciences
Soon-Chan Kim, Young-Eun Cho, Young-Kyoung Shin, Hyeon Jong Yu, Tamrin Chowdhury, Sojin Kim, Kyung Sik Yi, Chi-Hoon Choi, Sang-Hoon Cha, Chul-Kee Park, Ja-Lok Ku
Article
Multidisciplinary Sciences
Soon-Chan Kim, Young-Eun Cho, Young-Kyoung Shin, Hyeon Jong Yu, Tamrin Chowdhury, Sojin Kim, Kyung Sik Yi, Chi-Hoon Choi, Sang-Hoon Cha, Chul-Kee Park, Ja-Lok Ku
Summary: Glioblastoma (GBM) is a deadly intracranial tumor. Sequencing technologies have helped in personalized therapy for GBM, but in vitro and in vivo models are needed to validate in silico evaluations of genomic features. GBM cell lines with whole exome sequencing (WES) datasets of matched tumor tissues and blood can be used to investigate molecular markers and validate druggable targets. A complete WES dataset of 26 GBM patient-derived cell lines along with their matched tumor tissues and blood is provided to show that cell lines can largely recapitulate genomic profiles of original tumors.
Article
Engineering, Biomedical
Yun-Sik Dho, Byeong Cheol Lee, Hyeong Cheol Moon, Kyung Min Kim, Ho Kang, Eun Jung Lee, Min-Sung Kim, Jin Wook Kim, Yong Hwy Kim, Sang Joon Park, Chul-Kee Park
Summary: Concomitant with advances in computing technology, augmented reality-based navigation in clinical applications is being researched. Novel object tracking and depth realization technologies were developed for augmented reality-based neuronavigation in brain surgery. The results validate the efficacy of these technologies in overcoming critical obstacles in the development of clinically applicable augmented reality neuronavigation.
INTERNATIONAL JOURNAL OF COMPUTER ASSISTED RADIOLOGY AND SURGERY
(2023)
Review
Clinical Neurology
Chul-Kee Park, Jong Hee Chang
Summary: Recent updates in genomic-integrated glioma classification have caused confusion in clinical practice, but the Korean Brain Tumor Society conducted a questionnaire survey to gain consensus on risk group categorization and treatment preferences. They found agreement on dichotomic definition of risk groups and consistent decisions based on WHO grade and risk group for treatment protocols. Temporary consensus and available options will aid management until more evidence is accumulated under the new classification system.
JOURNAL OF KOREAN NEUROSURGICAL SOCIETY
(2023)
Article
Clinical Neurology
Moonyoung Chung, Hee-Jin Yang, Chul-Kee Park
Summary: This article reviews the history of the Journal of Korean Neurosurgical Society and discusses future development directions.
JOURNAL OF KOREAN NEUROSURGICAL SOCIETY
(2022)
Review
Clinical Neurology
Chul-Kee Park
Summary: This article summarizes and discusses the development and application of 3D-printed neurosurgical disease models, which can help neurosurgeons in spatial perception during surgical planning, simulation, and training.
JOURNAL OF KOREAN NEUROSURGICAL SOCIETY
(2022)
Review
Oncology
Xinru Zhou, Yin Jia, Chuanbin Mao, Shanrong Liu
Summary: Small extracellular vesicles (sEVs), such as exosomes, have emerged as crucial targets for liquid biopsy and promising drug delivery vehicles in tumor progression. They can serve as biomarkers for tumor diagnosis and as drug carriers for cancer treatment.
Article
Oncology
Ruochan Chen, Ju Zhu, Xiao Zhong, Jie Li, Rui Kang, Daolin Tang
Summary: The interplay between autophagy and apoptosis plays a crucial role in tumorigenesis and cancer therapy, with HMGB1 serving as a key regulator in these processes.
Article
Oncology
Zongfu Pan, Xixuan Lu, Tong Xu, Jinming Chen, Lisha Bao, Ying Li, Yingying Gong, Yulu Che, Xiaozhou Zou, Zhuo Tan, Ping Huang, Minghua Ge
Summary: This study uncovered the emerging role of HN1 in promoting dedifferentiation of anaplastic thyroid cancer (ATC) cells. HN1 negatively regulated the thyroid differentiation markers and had an inhibitory effect on the transcriptional activation of CTCF, thereby influencing the chromatin accessibility of thyroid differentiation genes.
Article
Oncology
Yi Qin, Shengjun Xiong, Jun Ren, Gautam Sethi
Summary: Autophagy plays an important regulatory role in glioblastoma, and its dysregulation can lead to drug resistance and radioresistance. It also affects stem cell characteristics, overall growth, and metastasis. Therefore, autophagy is a promising target for glioblastoma therapy.
Article
Oncology
Katsuya Nagaoka, Xuewei Bai, Dan Liu, Kevin Cao, Joud Mulla, Chengcheng Ji, Hongze Chen, Muhammad Azhar Nisar, Amalia Bay, William Mueller, Grace Hildebrand, Jin-Song Gao, Shaolei Lu, Hiroko Setoyama, Yasuhito Tanaka, Jack R. Wands, Chiung-Kuei Huang
Summary: This study found that serum 2-OG levels in cholangiocarcinoma patients are associated with the effectiveness of chemotherapy. Patients with progressive disease showed significantly higher levels of serum 2-OG compared to stable disease and partial response patients. The study also revealed that overexpression of ASPH mimics the effects of 2-OG, and knockdown of ASPH improves chemotherapy. Targeting ASPH enhances the effects of chemotherapy by modulating ATM and ATR, two key regulators of DDRs.