期刊
CANCER LETTERS
卷 325, 期 2, 页码 220-226出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2012.07.009
关键词
Carcinoma; Non-small-cell lung; Interleukin-1beta; Transforming growth factor beta; Matrix metalloproteinases
类别
资金
- VA Career Development Award
- VA Merit Review Award
- Div Of Biological Infrastructure
- Direct For Biological Sciences [1039423] Funding Source: National Science Foundation
Cytokines present in the tumor microenvironment can promote the invasiveness and metastatic potential of cancer cells. We therefore investigated the effects of interleukin-1 beta (IL-1B) and transforming growth factor beta-3 (TGFB3) on the non-small cell lung carcinoma (NSCLC) cell line A549. We found that these cytokines synergistically activated matrix metalloproteinase (MMP)-1, MMP-3, and MMP-10 gene expression in these cells through mitogen-activated protein kinase (MAPK)-dependent pathways. Consistent with this, both cytokines stimulated epithelial to mesenchymal transition and MAPK-dependent invasion through Matrigel (TM). These studies identify IL-1B and TGFB3 as pro-invasive factors in NSCLC and potential therapeutic targets for tumor progression. Published by Elsevier Ireland Ltd.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据