期刊
CANCER LETTERS
卷 310, 期 1, 页码 77-83出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2011.06.018
关键词
Convection-enhanced delivery; Local chemotherapy; Blood-brain barrier; Brain tumor; ACNU
类别
资金
- Ministry of Health, Labour and Welfare in Japan [21791341]
- Grants-in-Aid for Scientific Research [23791583, 21390401, 21791341, 21249077] Funding Source: KAKEN
Recently, local chemotherapy proved its efficacy against malignant gliomas. Under the hypothesis that local delivery of chemotherapeutic agents into the brain parenchyma induce opening of the blood-brain barrier (BBB), we evaluated the opening of BBB after convection-enhanced delivery of nimustine hydrochloride into the brain parenchyma. Local convection-enhanced delivery of nimustine hydrochloride transiently opened the BBB from about 7-12 days after delivery in normal rodent brain. Systemic chemotherapy during this period of BBB disruption had synergistic effects resulting in prolonged survival of tumor-bearing rats. The present strategy may provide a new approach for glioma chemotherapy. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
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