期刊
CANCER LETTERS
卷 310, 期 2, 页码 140-147出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2011.06.030
关键词
P300; HCC; Overall survival; E-cadherin; Tumor invasion
类别
资金
- Ministry of Education and Science in Japan [20590790]
- Grants-in-Aid for Scientific Research [23590984, 20590790, 23590470] Funding Source: KAKEN
P300 impacts the transcription of several genes involved in biological behavior of human malignancies including hepatocellular carcinomas (HCC). We found p300 is highly expressed in 47% of surgically resected HCC specimens by immunohistochemistry, which correlated with advanced TNM staging (P = 0.034), vascular invasion (P = 0.036), intrahepatic metastasis (P = 0.001) and shortened overall survival (P = 0.028). In vitro study, knocking down of p300 expression in hepatoma cells recovered E-cadherin expression, inhibited the translocation of beta (beta)-catenin into the nuclei, decreased cyclin D1 activity and suppressed the migration/invasion of HCC cells. Furthermore, suppression of p300 led to down-regulation of epithelial-mesenchymal transition (EMT)-related molecules such as Snail, Twist and HIF-1 alpha. These observations suggest that p300 contributes to the EMT-related progression of HCCs. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
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