期刊
CANCER LETTERS
卷 312, 期 1, 页码 1-10出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2011.06.028
关键词
MSCs; Neuroblastoma; SDF-1; CXCR4; CXCR7
类别
资金
- Hotung SK Fund
- CRCG
- HKU
Bone marrow metastasis is frequently observed in patients with high-risk neuroblastoma. Mesenchymal stromal cells (MSCs) in bone marrow may enhance tumor metastasis through secreting stromal cell-derived factor-1 (SDF-1). Here we investigated neuroblastoma cell behaviors under the influence of MSCs and explored the function of SDF-1 signaling during metastasis. Neuroblastoma expressed both of the SDF-1 receptors CXCR4 and CXCR7. shRNA knockdown showed that these receptors were responsible for the migration of neuroblastoma towards MSCs. CXCR4 also supported neuroblastoma invasion. These effects could be effectively blocked by AMD3100, a potent SDF-1 antagonist. Our study suggests that MSCs are important for neuroblastoma metastasis via the secretion of SDP-1 and that such effect can be inhibited by AMD3100 or shRNA knockdown. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
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