Article
Medicine, Research & Experimental
Mariko Miyashita-Ishiwata, Malak El Sabeh, Lauren D. Reschke, Sadia Afrin, Mostafa A. Borahay
Summary: This study reveals an aberrant response of leiomyoma cells to hypoxia, characterized by increased cell proliferation and secretion of angiogenic factors. This abnormal response may contribute to the development and growth of leiomyoma.
Article
Biotechnology & Applied Microbiology
Ling Sun
Summary: Silencing FBXW7 upregulates the HIF-1α/VEGF signaling pathway, promoting angiogenesis in neonatal rats with hypoxic-ischemic brain damage (HIBD) after brain injury, reducing infarct volume and improving recovery of nerve function in HIBD rats.
Article
Oncology
Ali Abdalla, Chandraprabha Murali, Amr Amin
Summary: This study reveals for the first time the antiangiogenic potential of safranal and proposes its possible underlying mechanism in the treatment of hepatocellular carcinoma (HCC).
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jijun Fu, Wenjuan Zeng, Minshan Chen, Lijuan Huang, Songpei Li, Zhan Li, Qianrong Pan, Sha Lv, Xiangyu Yang, Ying Wang, Mengmeng Yi, Jianye Zhang, Xueping Lei
Summary: Apigenin not only inhibits the motility of tumor-related cells, but also reduces pericyte coverage. Further research shows that apigenin suppresses tumor angiogenesis by inhibiting HIF-1α and its downstream signaling pathways. In cell and animal models, apigenin exhibits a perfect anti-angiogenic effect and suppresses tumor growth. These findings suggest that apigenin may serve as a safe and effective angiogenesis inhibitor for NSCLC therapy.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Oncology
Jeong Eun Cha, Woom-Yee Bae, Jae-Sun Choi, Seung Hyeun Lee, Joo-Won Jeong
Summary: The study focused on the dependence of gefitinib resistance on HIF-1 alpha activity, showing that HIF-1 alpha was associated with the acquisition of resistance to gefitinib in NSCLC cell lines. Inhibition of HIF-1 alpha alleviated gefitinib resistance, indicating a potential strategy for developing anticancer drugs in combination with EGFR-TKIs for NSCLC patients.
Article
Cell Biology
Yonghua Zheng, Huaxia Ji, Wulin Yi, Zhanjun Chen, Xiaobiao Hu, Jie Zhou, Yang Wang, Xiao Zheng
Summary: PRMT5 is overexpressed in lung cancer cells and tissues, and its expression is induced by hypoxia. Inhibiting or silencing PRMT5 disrupts the phosphorylation of the VEGFR/Akt/eNOS angiogenic signaling pathway, NOS activity, and NO production. Additionally, inhibiting PRMT5 activity reduces HIF-1a expression and stability, resulting in the down-regulation of the VEGF/VEGFR signaling pathway. Our study provides compelling evidence of the close association between PRMT5 and angiogenesis/EMT and highlights the potential of targeting PRMT5 activity as a promising therapeutic approach for treating lung cancer with abnormal angiogenesis.
Article
Neurosciences
Yang Li, Tingting Ma, Xiaoyu Zhu, Mingqi Zhang, Liang Zhao, Peng Wang, Jia Liang
Summary: This study found that zinc improves neurological function recovery during the cerebral ischemia repair stage by promoting astrocyte induced angiogenesis. Zinc alleviates brain atrophy and enhances neurological function recovery. Furthermore, zinc increases the protein levels of HIF-1 alpha, VEGF-A, and VEGF-R2 in astrocytes, thereby promoting angiogenesis during cerebral ischemic repair.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Balaji Kyathegowdanadoddi Srinivas, Madhu Chakkere Shivamadhu, Shankar Jayarama
Summary: This study aimed to purify lectin from the sap of Musa acuminate pseudostem and investigate its apoptotic and angiogenic mechanisms in both in-vitro and in-vivo models. The findings suggest that the lectin possesses significant anticancer potential by inducing apoptosis and suppressing neoangiogenesis in cancer cells and animal models.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Pharmacology & Pharmacy
Nurina Febriyanti Ayuningtyas, Chanbora Chea, Toshinori Ando, Karina Erda Saninggar, Keiji Tanimoto, Toshihiro Inubushi, Nako Maishi, Kyoko Hida, Masanobu Shindoh, Mutsumi Miyauchi, Takashi Takata
Summary: This study evaluated the inhibitory effects of bovine lactoferrin (bLF) on tumor angiogenesis in vivo and in vitro. The results showed that bLF inhibited proliferation, migration, and tube formation in tumor endothelial cells (TECs) while promoting apoptosis. This effect was achieved through the inhibition of p-p65 via binding with TNF receptor-associated factor 6 (TRAF6), leading to the down-regulation of hypoxia inducible factor-alpha (HIF-1 alpha) and vascular endothelial growth factor (VEGF), specifically in TECs.
Article
Oncology
Yueyang Mou, Yaqin Hu, Guolian Xue, Wenjian Zhao, Yang Jiao, Chen Li, Haiyan Cao, Min Chao, Jianping Deng, Penggao Dai, Hongli Zhu, Liang Wang
Summary: ELK3 plays a crucial role in glioma angiogenesis by activating the HIF-1 alpha/VEGF-A signaling axis. It may serve as a prognostic marker for glioma angiogenesis and targeting ELK3 may improve the efficacy of anti-angiogenic therapies.
Article
Oncology
Chaojie Li, Nannan Yang, Zhijin Chen, Ning Xia, Qungang Shan, Ziyin Wang, Jian Lu, Mingyi Shang, Zhongmin Wang
Summary: Our study revealed that Tie1 is upregulated in a hypoxic environment in non-small cell lung carcinoma (NSCLC) cells, promoting stemness and resistance to cisplatin. Silencing Tie1 reduced stemness properties and increased sensitivity to cisplatin, suggesting its role in tumorigenesis and drug resistance in NSCLC. Additionally, Tie1 expression was induced by hypoxia in an HIF-1 alpha-dependent manner, further supporting its involvement in promoting stemness and drug resistance in NSCLC.
CANCER CELL INTERNATIONAL
(2021)
Article
Medicine, Research & Experimental
Xiaowei Wu, Minjie Li, Ying Li, Yu Deng, Shun Ke, Fan Li, Yujin Wang, Shuchang Zhou
Summary: The study demonstrated that FGF11 acts as an oncogene in non-small cell lung cancer, while miR-525-5p may negatively regulate FGF11. Targeting FGF11 and HIF-1 alpha could serve as novel strategies for the treatment of NSCLC.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Medicine, Research & Experimental
Meng Dai, Chunyu Hua, Mingqin Wang, Li Gao, Ling Jiang, Yuan Liu
Summary: This study reveals that BPTF promotes tumor angiogenesis in lung adenocarcinoma by positively regulating the expression of VEGF. Higher expression of BPTF and VEGF is associated with lymph node metastasis and clinical stage, while lower expression is correlated with a higher 5-year survival rate. Furthermore, patients with BPTF overexpression are more likely to have a better response to bevacizumab treatment.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2022)
Article
Oncology
Fan Luo, Fei-Teng Lu, Jia-Xin Cao, Wen-Juan Ma, Zeng-Fei Xia, Jian-Hua Zhan, Kang-Mei Zeng, Yan Huang, Hong-Yun Zhao, Li Zhang
Summary: The inhibition of HIF-1 alpha has been found to synergize with anti-PD-1 therapy in impairing tumor growth in NSCLC, enhancing anti-tumor immunity.
Article
Chemistry, Medicinal
Donghwa Kim, Sang Won Choi, Jihee Cho, Jae-Hui Been, Kyoungsun Choi, Wenzhe Jiang, Jaeho Han, Jedo Oh, Changmin Park, Soongyu Choi, Songyi Seo, Koung Li Kim, Wonhee Suh, Sang Kook Lee, Sanghee Kim
Summary: Diabetic retinopathy is a leading cause of blindness associated with excessive angiogenesis. Researchers have developed a novel antiangiogenesis agent by modifying the structure of wondonin marine natural products, resulting in improved bioactivity and selectivity. This compound, 31, shows potential as a lead for developing small-molecule drugs to treat diabetic retinopathy and to uncover new mechanisms of angiogenesis.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Oncology
Xinru Zhou, Yin Jia, Chuanbin Mao, Shanrong Liu
Summary: Small extracellular vesicles (sEVs), such as exosomes, have emerged as crucial targets for liquid biopsy and promising drug delivery vehicles in tumor progression. They can serve as biomarkers for tumor diagnosis and as drug carriers for cancer treatment.
Article
Oncology
Ruochan Chen, Ju Zhu, Xiao Zhong, Jie Li, Rui Kang, Daolin Tang
Summary: The interplay between autophagy and apoptosis plays a crucial role in tumorigenesis and cancer therapy, with HMGB1 serving as a key regulator in these processes.
Article
Oncology
Zongfu Pan, Xixuan Lu, Tong Xu, Jinming Chen, Lisha Bao, Ying Li, Yingying Gong, Yulu Che, Xiaozhou Zou, Zhuo Tan, Ping Huang, Minghua Ge
Summary: This study uncovered the emerging role of HN1 in promoting dedifferentiation of anaplastic thyroid cancer (ATC) cells. HN1 negatively regulated the thyroid differentiation markers and had an inhibitory effect on the transcriptional activation of CTCF, thereby influencing the chromatin accessibility of thyroid differentiation genes.
Article
Oncology
Yi Qin, Shengjun Xiong, Jun Ren, Gautam Sethi
Summary: Autophagy plays an important regulatory role in glioblastoma, and its dysregulation can lead to drug resistance and radioresistance. It also affects stem cell characteristics, overall growth, and metastasis. Therefore, autophagy is a promising target for glioblastoma therapy.
Article
Oncology
Katsuya Nagaoka, Xuewei Bai, Dan Liu, Kevin Cao, Joud Mulla, Chengcheng Ji, Hongze Chen, Muhammad Azhar Nisar, Amalia Bay, William Mueller, Grace Hildebrand, Jin-Song Gao, Shaolei Lu, Hiroko Setoyama, Yasuhito Tanaka, Jack R. Wands, Chiung-Kuei Huang
Summary: This study found that serum 2-OG levels in cholangiocarcinoma patients are associated with the effectiveness of chemotherapy. Patients with progressive disease showed significantly higher levels of serum 2-OG compared to stable disease and partial response patients. The study also revealed that overexpression of ASPH mimics the effects of 2-OG, and knockdown of ASPH improves chemotherapy. Targeting ASPH enhances the effects of chemotherapy by modulating ATM and ATR, two key regulators of DDRs.
