期刊
CANCER LETTERS
卷 307, 期 2, 页码 211-220出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2011.04.005
关键词
Bladder cancer; MicroRNA-143; Tumor suppressor; ERK5; Akt
类别
资金
- Ministry of Education, Science, Sports, and Culture of Japan
MicroRNA (miR)-143 and -145 were down-regulated in human bladder cancer T24 cells. The enforced expression of miR-143 induced growth-suppression in T24 cells through down-regulation of ERK5 and Akt expression at translational level, and chemically-modified synthetic miR-143 (miR-143/BP) exhibited a greater growth inhibitory effect than wild-type miR-143. In addition, the synthetic miR-143/BP induced apoptotic cell death in some of the transfected cells. Furthermore, co-treatment with the synthetic miR-143/BP and cisplatin showed the additive growth-suppressing effect on T24 cells. These findings suggest that the chemically-modified synthetic miR-143 functions as a tumor suppressor in 124 cells by targeting ERK5 and/or Akt. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
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