Review
Biochemistry & Molecular Biology
Ahmed M. Elshazly, David A. Gewirtz
Summary: BET family inhibitors target dysregulated epigenetic readers and are being investigated for their therapeutic benefits in pre-clinical studies and clinical trials. However, resistance development poses a challenge to these inhibitors. This review explores the functions of autophagy in tumor models exposed to BET inhibitors and examines whether targeting or modulation of autophagy could enhance the therapeutic response and overcome resistance to BET inhibition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Manuel Perez-Garnes, Victoria Morales, Raul Sanz, Rafael A. Garcia-Munoz
Summary: Hollow-shell mesoporous silica nanoparticles encapsulating iron oxide were prepared using a drug-structure-directing agent concept, showing potential for theranostic applications. These nanoparticles can load and release drugs to specific target cells, overcoming limitations of conventional formulations in reaching desired sites.
Article
Biochemistry & Molecular Biology
Elena G. Varlamova, Mikhail Goltyaev, Aleksander Simakin, Sergey Gudkov, Egor A. Turovsky
Summary: This study developed a selenium-sorafenib nanocomplex and investigated its molecular mechanisms in anticancer effect on human hepatocyte carcinoma cells. The results indicate that selenium nanoparticles have a significant pro-apoptotic effect, while the selenium-sorafenib nanocomplex is even more effective.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Masa Bosnjak, Tanja Jesenko, Bostjan Markelc, Anja Cerovsek, Gregor Sersa, Maja Cemazar
Summary: This study evaluated the cytotoxicity of chemotherapeutic drugs bleomycin and cisplatin in pancreatic cancer cell line and explored their interactions with targeted drug sunitinib in electrochemotherapy (ECT). The results demonstrated that ECT was effective in pancreatic cancer cells, especially when used with bleomycin. Additionally, combining ECT, bleomycin, and sunitinib enhanced cytotoxicity. Therefore, the combined treatment of ECT and sunitinib has clinical potential for patients with unresectable locally advanced pancreatic cancer.
RADIOLOGY AND ONCOLOGY
(2022)
Article
Environmental Sciences
Gang Wei, Cao-xu Zhang, Yu Jing, Xia Chen, Huai-dong Song, Liu Yang
Summary: This study evaluated the toxic effects of sorafenib and sunitinib on zebrafish embryos/larvae, showing remarkable developmental toxicities and disruptions in the thyroid endocrine system, with effects on hormone levels and gene transcription within the HPT axis. Abnormal thyroid gland organogenesis was also observed in response to these drugs, suggesting a potential regulatory mechanism by affecting the thyroid follicle structure and HPT axis balance.
Article
Plant Sciences
Werner Cordier, Paul Steenkamp, Vanessa Steenkamp
Summary: The cytotoxicity and toxicity mechanisms of Acokanthera oppositifolia herbal extracts were assessed on HepG2 hepatocarcinoma cells. The extracts showed toxic effects on cell density, oxidative status, mitochondrial membrane potential, cell cycle, apoptosis, and caspase-3/7 activity. The extracts also reduced glutathione and adenosine triphosphate levels while increasing fatty acid accumulation. These results suggest that A. oppositifolia extracts may have hepatotoxic effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Chemistry, Physical
Elena D. Stolyarova, Artem A. Mikhailov, Anton A. Ulantikov, Julia A. Eremina, Lyubov S. Klyushova, Natalia Kuratieva, Vladimir A. Nadolinny, Gennadiy A. Kostin
Summary: Two nitrosyl complexes were synthesized and characterized, showing light-induced NO release and cytotoxicity against breast adenocarcinoma cells. Photolysis and electrochemical techniques were used to investigate the activation of NO, and DFT calculations revealed possible charge transfers responsible for the activation. The study opens up possibilities for designing and synthesizing new compounds with photo-sensitive and cytotoxic properties.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Amna Mohamed Taha, Mohammad Mabrouk Aboulwafa, Hamdallah Zedan, Omneya Mohamed Helmy
Summary: Combining sorafenib with ramucirumab or panitumumab resulted in a significant decrease in sorafenib IC50, inhibited proliferation and angiogenesis, induced apoptosis, and altered the expression of various proteins related to cell cycle and apoptosis in HepG2 cancer cells. This suggests that ramucirumab may be a useful adjunct therapy to enhance sorafenib efficacy in HCC therapy.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Eva Juengel, Pascal Schnalke, Jochen Rutz, Sebastian Maxeiner, Felix K. -H. Chun, Roman A. Blaheta
Summary: Axitinib significantly suppressed the growth of sunitinib-resistant HUVECs and induced cell cycle arrest at the G0/G1 phase. Both axitinib and sorafenib reduced HUVEC tube length and prevented wound closure in sunitinib-resistant HUVECs after six weeks of treatment, with sorafenib showing slightly better results.
Article
Endocrinology & Metabolism
Sijia Guo, Chenhao Zhang, Haiou Zeng, Yantao Xia, Chenghao Weng, Yichen Deng, Luda Wang, Huan Wang
Summary: HCC is a deadly cancer with limited treatment options. Sorafenib, a first-line treatment for HCC, induces aerobic glycolysis, leading to drug resistance. The duration of AMPK activation is important for cancer evasion of therapeutic treatment, and glycolysis is a key regulator of AMPK activation duration.
MOLECULAR METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Kitti Andreidesz, Aliz Szabo, Dominika Kovacs, Balazs Koszegi, Viola Bagone Vantus, Eszter Vamos, Mostafa Isbera, Tamas Kalai, Zita Bognar, Krisztina Kovacs, Ferenc Gallyas
Summary: HO-5114, a novel mitochondria-targeted compound, showed high cytotoxicity against human breast cancer cell lines by significantly reducing viability and promoting apoptosis. However, the drug did not significantly increase reactive oxygen species, indicating that oxidative stress may not play a major role in its anti-neoplastic effect.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Nabil A. Alhakamy, Shaimaa M. Badr-Eldin, Hibah M. Aldawsari, Anas Alfarsi, Thikryat Neamatallah, Solomon Z. Okbazghi, Usama A. Fahmy, Osama A. A. Ahmad, Basma G. Eid, Wael Ali Mahdi, Adel F. Alghaith, Sultan Alshehri, Shadab Md
Summary: FLV-loaded emulsomes were formulated and optimized to improve formulation efficiency for prostate cancer treatment. The optimized FLV-loaded emulsomes demonstrated significant antitumor activity in prostate cancer cells.
Article
Chemistry, Multidisciplinary
Lukas Hanzl, Jaromir Vinklarek, Jan Honzicek, Libor Dostal, Ivana Cisarova, Lucie Sacherlova, Ales Eisner, Darina Muthna, Martina Rezacova
Summary: A series of molybdenum(II) compounds with different ligands have been synthesized and characterized. The results showed that substitution in the π-ligand, in combination with suitable N,N-chelating ligands, could lead to species with significantly higher cytotoxicity than cisplatin. Compounds with phenanthroline ligands exhibited unusually high activity, and derivatives with ether and thioether ligands showed enhanced cytotoxicity towards leukemia cells.
Review
Immunology
Hayder M. M. Al-Kuraishy, Ali I. I. Al-Gareeb, Hebatallah M. M. Saad, Gaber El-Saber Batiha
Summary: Multiple sclerosis (MS) is a chronic progressive disease characterized by demyelination and neuronal injury. Dyslipidemia is an important risk factor in MS pathogenesis, and chronic inflammation in MS can lead to dyslipidemia. This review explores the effects of statins on MS, finding that while statins can have protective effects in the acute phase through anti-inflammatory and antioxidant mechanisms, they may have detrimental effects in the chronic phase by reducing brain cholesterol and inhibiting remyelination.
INFLAMMOPHARMACOLOGY
(2023)
Review
Immunology
Seyyed Mostafa Arabi, Leila Sadat Bahrami, Mahsa MalekAhmadi, Mahla Chambari, Narges Milkarizi, Alexander N. Orekhov, Amirhossein Sahebkar
Summary: This systematic review and meta-analysis evaluates the impact of combination therapy with statins and ezetimibe on proinflammatory cytokines. The results indicate that the combination therapy does not significantly reduce IL-1 beta, TNF-alpha, and MCP-1, but shows significant reductions in IL-6 and IFN-gamma levels. Furthermore, the reduction in IL-6 is particularly significant among individuals aged >= 60 years and the Asian population.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Oncology
Aleksander Slusarczyk, Piotr Zapala, Lukasz Zapala, Piotr Radziszewski
Summary: Smoking is associated with a higher risk of recurrence and progression in non-muscle invasive bladder cancer (NMIBC) patients. Smoking has a detrimental effect on the survival rate of recurrence and progression in NMIBC patients.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Piotr Zapala, Karolina Garbas, Zbigniew Lewandowski, Aleksander Slusarczyk, Cezary Slusarczyk, Lukasz Mielczarek, Giancarlo Marra, Benjamin Pradere, Pawel Rajwa, Lukasz Zapata, Piotr Radziszewski
Summary: The study aimed to determine the clinical utility of neutrophil-to-lymphocyte ratio (NLR) in predicting nodal involvement in prostate cancer patients treated with radical prostatectomy. The retrospective study included 205 patients and found that higher NLR was associated with lower incidence of nodal spread. Additionally, higher NLR in nodal-positive patients was correlated with shorter survival.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Lukasz Zapala, Grzegorz Niemczyk, Piotr Zapala, Artur Wdowiak, Iwona Bojar, Tomasz Kluz, Aleksandra Szopa, Anna Serefko, Piotr Radziszewski, Andrzej Wrobel
Summary: This paper aimed to investigate whether the selective cannabinoid CB1 receptor agonist ACEA could reverse the effects of corticosterone (CORT) on depressive and overactive bladder potential. Through experiments on 48 female rats, it was found that ACEA could restore CORT-induced bladder dysfunction and depressive behavior, as well as regulate urine and other biomarkers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Piotr Sklepkiewicz, Barbara Dymek, Michal Mlacki, Agnieszka Zagozdzon, Magdalena Salamon, Anna Maria Siwinska, Marcin Piotr Mazurkiewicz, Natalia de Souza Xavier Costa, Marzena Mazur, Thais Mauad, Adam Golebiowski, Karolina Dzwonek, Jakub Golab, Zbigniew Zaslona
Summary: Chitotriosidase (CHIT1) is an enzyme that regulates macrophages and their role in asthma development was investigated. The expression of CHIT1 was examined in lung tissues of individuals with severe, uncontrolled, steroid-naive asthma, and a chitinase inhibitor called OATD-01 was tested in a mouse model of chronic asthma. The results showed that inhibiting CHIT1 had beneficial effects, reducing inflammation and airway remodeling in asthma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Aleksandra Paterek, Marta Okninska, Zofia Pilch, Anna Sosnowska, Kavita Ramji, Urszula Mackiewicz, Jakub Golab, Dominika Nowis, Michal Maczewski
Summary: This study aims to investigate the improvement of cardiac toxicity caused by multiple myeloma and the therapeutic drug bortezomib through the enhancement of endothelial function. The results showed that bortezomib exacerbated the cardiac toxicity caused by multiple myeloma, while an arginase inhibitor partially prevented this effect. Therefore, arginase inhibitors may offer promise in the prevention/treatment of cardiac toxicity in multiple myeloma.
Article
Biochemistry & Molecular Biology
Andrzej Wozniak, Slawomir Wozniak, Ewa Poleszak, Tomasz Kluz, Lukasz Zapala, Aleksander Wozniak, Tomasz Rechberger, Andrzej Wrobel
Summary: The postmenopausal state affects a large percentage of women's lives and many experience GSM symptoms such as vaginal dryness, itching, inflammations, lack of elasticity, or dyspareunia. This study found that fractional CO2 laser treatment effectively improved these symptoms and increased the quality of life for women. The treatment restored the correct structure and composition of the vaginal epithelium, leading to positive results in both objective and subjective evaluations.
Article
Health Care Sciences & Services
Patryk Buller, Adam Kern, Maciej Tyczynski, Wojciech Rosiak, Wlodzimierz Figatowski, Robert J. Gil, Jacek Bil
Summary: This study aimed to compare the characteristics and outcomes between patients with myocardial infarction with non-obstructive coronary arteries (MINOCA) and STEMI patients in a 5-year follow-up, and found that the outcomes of both groups were comparable in the 5-year follow-up.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Medicine, General & Internal
Maciej Tyczynski, Adam Kern, Patryk Buller, Wojciech Wanha, Robert J. Gil, Jacek Bil
Summary: The study aimed to assess the performance and safety of PCI in CHIP and HBR patients. The findings showed that although PCI in these patients had a low rate of complications, they were at a high risk of future adverse events, highlighting the importance of close monitoring to improve outcomes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Editorial Material
Oncology
Aimin Jiang, Lukasz Zapala, Le Qu, Linhui Wang
FRONTIERS IN ONCOLOGY
(2023)
Article
Health Care Sciences & Services
Maciej Tyczynski, Adam Kern, Patryk Buller, Robert J. Gil, Jacek Bil
Summary: We evaluated the performance and safety of a second-generation thin-strut sirolimus-eluting stent, Alex Plus, in patients with acute coronary syndrome (ACS). The study findings showed that Alex Plus was effective and safe in real-world ACS patients undergoing primary PCI, with comparable outcomes to patients with chronic coronary syndrome.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Medicine, Research & Experimental
Le Qu, Hui Chen, Qi Chen, Silun Ge, Aimin Jiang, Nengwang Yu, Yulin Zhou, Michal Kunc, Ye Zhou, Xiang Feng, Wei Zhai, Zhenjie Wu, Miaoxia He, Yaoming Li, Rui Chen, Bo Han, Xing Zeng, Yao Fu, Changwei Ji, Xiang Fan, Guangyuan Zhang, Cheng Zhao, Taile Jing, Chenchen Feng, Hongwei Zhao, Di Sun, Liang Wang, Sheng Tai, Cheng Zhang, Shaohao Chen, Yixun Liu, Haifeng Wang, Jinli Gao, Yufeng Gu, He Miao, Tangliang Zhao, Xiaoming Yi, Chaopeng Tang, Dian Fu, Haowei He, Qiu Rao, Wenquan Zhou, Ning Xu, Gongxian Wang, Chaozhao Liang, Zhiyu Liu, Dan Xia, Xiongbing Zu, Ming Chen, Hongqian Guo, Weijun Qin, Zhe Wang, Wei Xue, Benkang Shi, Shaogang Wang, Junhua Zheng, Cheng Chen, Lukasz Zapala, Jingping Ge, Linhui Wang
Summary: Through whole-exome sequencing, it was found that metastases in nonmetastatic ccRCC patients mainly originated from venous tumor thrombus (VTT) rather than primary tumors. Pathological grading of VTT outperformed other indicators in risk assessment. A new prognostic tool, TT-GPS score, incorporating VTT grading, showed better discriminatory ability in predicting the survival of nonmetastatic ccRCC patients with VTT compared to previously reported models.
Review
Urology & Nephrology
Evangelos N. Symeonidis, Domenico Veneziano, Hendrik Borgmann, Lukasz Zapata, Athanasios Zachariou, Horst Brenneis, Stefan M. Haensel, Helmut Haas, Fotios Dimitriadis
Summary: This article examines the past, present, and future roles of telemedicine in urology. The evidence supports telemedicine as a viable, safe, and convenient alternative to in-person clinical visits for most urological diagnoses.
EUROPEAN UROLOGY OPEN SCIENCE
(2023)
Article
Medicine, General & Internal
Jacek Bil, Adam Kern, Kamil Bujak, Marek Gierlotka, Jacek Legutko, Mariusz Gasior, Wojciech Wanha, Leszek Gromadzinski, Robert J. Gil
Summary: This study compared the characteristics and 12-month clinical outcomes of patients with MINOCA treated before and during the COVID-19 pandemic. The rate of MINOCA was lower in 2020 and in-hospital stroke rates were higher during the pandemic. Further evaluation is needed to assess the association between worse clinical outcomes of MINOCA patients treated during the pandemic and the increased risk for thromboembolic complications of SARS-CoV-2 infection.
POLISH ARCHIVES OF INTERNAL MEDICINE-POLSKIE ARCHIWUM MEDYCYNY WEWNETRZNEJ
(2023)
Article
Medicine, Research & Experimental
Olga Sokolowska, Anna Rodziewicz-Lurzynska, Zofia Pilch, Hanna Kedzierska, Justyna Chlebowska-Tuz, Anna Sosnowska, Anna Szumera-Cieckiewicz, Kamil Sokol, Joanna Barankiewicz, Aleksander Salomon-Perzynski, Olga Ciepiela, Ewa Lech-Maranda, Jakub Golab, Dominika Nowis
Summary: In the treatment of multiple myeloma, combining a STING agonist with bortezomib can significantly decrease tumor burden and improve the survival rate of patients. However, this therapy also increases the expression of PD-L1 on immune cells, and the addition of an anti-PD1 antibody can further enhance the therapeutic effects.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Review
Oncology
Xinru Zhou, Yin Jia, Chuanbin Mao, Shanrong Liu
Summary: Small extracellular vesicles (sEVs), such as exosomes, have emerged as crucial targets for liquid biopsy and promising drug delivery vehicles in tumor progression. They can serve as biomarkers for tumor diagnosis and as drug carriers for cancer treatment.
Article
Oncology
Ruochan Chen, Ju Zhu, Xiao Zhong, Jie Li, Rui Kang, Daolin Tang
Summary: The interplay between autophagy and apoptosis plays a crucial role in tumorigenesis and cancer therapy, with HMGB1 serving as a key regulator in these processes.
Article
Oncology
Zongfu Pan, Xixuan Lu, Tong Xu, Jinming Chen, Lisha Bao, Ying Li, Yingying Gong, Yulu Che, Xiaozhou Zou, Zhuo Tan, Ping Huang, Minghua Ge
Summary: This study uncovered the emerging role of HN1 in promoting dedifferentiation of anaplastic thyroid cancer (ATC) cells. HN1 negatively regulated the thyroid differentiation markers and had an inhibitory effect on the transcriptional activation of CTCF, thereby influencing the chromatin accessibility of thyroid differentiation genes.
Article
Oncology
Yi Qin, Shengjun Xiong, Jun Ren, Gautam Sethi
Summary: Autophagy plays an important regulatory role in glioblastoma, and its dysregulation can lead to drug resistance and radioresistance. It also affects stem cell characteristics, overall growth, and metastasis. Therefore, autophagy is a promising target for glioblastoma therapy.
Article
Oncology
Katsuya Nagaoka, Xuewei Bai, Dan Liu, Kevin Cao, Joud Mulla, Chengcheng Ji, Hongze Chen, Muhammad Azhar Nisar, Amalia Bay, William Mueller, Grace Hildebrand, Jin-Song Gao, Shaolei Lu, Hiroko Setoyama, Yasuhito Tanaka, Jack R. Wands, Chiung-Kuei Huang
Summary: This study found that serum 2-OG levels in cholangiocarcinoma patients are associated with the effectiveness of chemotherapy. Patients with progressive disease showed significantly higher levels of serum 2-OG compared to stable disease and partial response patients. The study also revealed that overexpression of ASPH mimics the effects of 2-OG, and knockdown of ASPH improves chemotherapy. Targeting ASPH enhances the effects of chemotherapy by modulating ATM and ATR, two key regulators of DDRs.
