Review
Biochemistry & Molecular Biology
Yiwen Zhang, Kunjian Liu, Chengqiu Yan, Yu Yin, Shuangyan He, Li Qiu, Guofeng Li
Summary: Natural polyphenols are promising chemopreventive agents for colorectal cancer, as they can regulate molecular and signaling pathways, inhibit tumor formation and progression. Combination treatment with different natural polyphenols can enhance the therapeutic effects and reduce side effects.
Article
Biochemistry & Molecular Biology
Michele Pellegrino, Emilia Bevacqua, Luca Frattaruolo, Anna Rita Cappello, Stefano Aquaro, Paola Tucci
Summary: Prostate cancer is the second most common cancer in men. Higher intake of polyphenols, curcumin, and quercetin has been associated with lower prostate cancer risk. In this study, the combination of curcumin and quercetin showed synergic anticancer and anti-inflammatory effects, inhibiting proliferation, inducing apoptosis, and modulating inflammation-mediated signaling pathways.
Review
Chemistry, Medicinal
Jinjiang Jiang, Bo Chen, Bo Tang, Qiang Wei
Summary: Selenium plays a crucial role in prostate cancer research, involving prevention, development, and treatment. It has shown promise in combinatorial therapy and is associated with various cellular processes. Selenium holds potential as a trace mineral for prostate cancer prevention, development, treatment, and exploration of novel agents.
Review
Oncology
Salma Benayad, Hicham Wahnou, Riad El Kebbaj, Bertrand Liagre, Vincent Sol, Mounia Oudghiri, El Madani Saad, Raphael Emmanuel Duval, Youness Limami
Summary: With its potential to inhibit cancer development, piperine, a natural compound, shows promise in cancer prevention and treatment.
Article
Medicine, General & Internal
Richard T. Bryan, Sarah J. Pirrie, Ben Abbotts, Shanna Maycock, Vinnie During, Carolyn Lewis, Margaret Grant, Deborah Bird, Adam J. Devall, D. Michael A. Wallace, Nicholas D. James, Lucinda J. Billingham, Maurice P. Zeegers, K. K. Cheng, SELENIB Investigators
Summary: In this multicenter clinical trial, selenium and vitamin E were found to have no significant effect on the risk of recurrence in patients with newly diagnosed non-muscle-invasive bladder cancer (NMIBC). However, vitamin E supplementation was associated with an increased risk of recurrence.
Review
Public, Environmental & Occupational Health
Kelly E. Lloyd, Louise H. Hall, Natalie King, Rachael J. Thorneloe, Rocio Rodriguez-Lopez, Lucy Ziegler, David G. Taylor, Mairead MacKenzie, Samuel G. Smith
Summary: The systematic review synthesized data on attitudes and behavior towards the use of aspirin for cancer prevention, as well as healthcare providers' attitudes towards implementing aspirin in practice. Eligible users of aspirin showed moderate to high willingness to participate in trials evaluating aspirin for preventive therapy, with high day-to-day adherence among trial participants. Healthcare providers generally perceived aspirin as a suitable option for cancer prevention.
PREVENTIVE MEDICINE
(2022)
Review
Oncology
Leandro de Lima Coutinho, Tharcisio Citrangulo Tortelli Junior, Maria Cristina Rangel
Summary: Cancer is a global public health problem with high morbidity and mortality rates. Plant-derived compounds, particularly sulforaphane (SFN), have shown chemopreventive and anticancer effects. SFN has also demonstrated the ability to target cancer stem cells (CSCs), a specific population of cancer cells with stem-like properties. This is particularly significant as most conventional chemotherapeutic agents cannot effectively target CSCs, which often exist in a quiescent state. SFN has the potential to be used in combination with conventional antineoplastic drugs in clinical settings.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Rebekah Law, Katherine Krupa, Jennifer Rusby
Summary: Breast cancer incidence in the UK is estimated to increase to 71,000 cases per year by 2035. Preventative therapy has the potential to significantly reduce this number, but its uptake remains low. Qualitative data was analyzed to inform future preventative efforts after establishing a preventative therapy clinic as part of a broader breast cancer prevention project.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Article
Medicine, Research & Experimental
Cecilia Villegas, Rebeca Perez, Olov Sterner, Ivan Gonzalez-Chavarria, Cristian Paz
Summary: Colorectal cancer is the second leading cause of cancer death worldwide, mainly affecting men, with about 20% of cases due to hereditary syndromes. Curcumin, the main polyphenol pigment in turmeric, has antioxidant properties and synergistic effects with both anticancer and anti-inflammatory drugs in inhibiting the progression of CRC through multiple signaling pathways.
Article
Biotechnology & Applied Microbiology
Huiting Lu, Shah Zada, Songsong Tang, Cheng Yaru, Wei Wei, Qiao Yuchun, Qiqi Yang, Jinya Du, Pengcheng Fu, Haifeng Dong, Xueji Zhang
Summary: In this study, optically active nanostructures consisting of chlorophyll and vanadium carbide nanosheets were developed for photodynamic/photo thermal therapy. The nanostructures showed advanced performance in killing cancer cells and completely ablated tumors in vivo, indicating their potential application in clinical tumor eradication.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Shuang Liang, Bin Liu, Xiao Xiao, Meng Yuan, Ling Yang, Ping'an Ma, Ziyong Cheng, Jun Lin
Summary: By engineering platinum and glutathione-modified vanadium tetrasulfide nanodendrites as a new sonosensitizer, the charge lifetime is extended and ROS production activity is significantly increased, leading to efficient tumor suppression.
ADVANCED MATERIALS
(2021)
Review
Biochemistry & Molecular Biology
Agnieszka Kaufman-Szymczyk, Wiktoria Kaczmarek, Krystyna Fabianowska-Majewska, Katarzyna Lubecka-Gajewska
Summary: Cancer is a leading cause of death worldwide, and the search for bioactive dietary compounds to prevent tumor development is crucial. Lunasin, a soy-derived peptide, has been studied for its anti-cancer activity for over 20 years. Previous research has shown that lunasin inhibits histone acetylation, regulates the cell cycle, suppresses proliferation, and induces apoptosis of cancer cells. It is considered a promising bioactive anti-cancer agent and a potent epigenetic modulator. This review discusses the molecular mechanisms and new perspectives on the application of lunasin in epigenetic prevention and anti-cancer therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Ya-Chu Tang, Yung-Jen Chuang, Hsin-Huei Chang, Shin-Hun Juang, Gow-Chin Yen, Jang-Yang Chang, Ching-Chuan Kuo
Summary: The induction of antioxidant proteins and detoxifying enzymes is crucial for protection against carcinogenesis. Activation of NRF2 can lead to the expression of cytoprotective proteins that play a role in defense against toxic and oxidative damages and therefore have potential in cancer chemoprevention. However, aberrant activation of NRF2 in cancer cells can contribute to tumor progression and drug resistance, making the inhibition of NRF2 signaling a promising approach for cancer therapy.
JOURNAL OF FOOD AND DRUG ANALYSIS
(2023)
Article
Oncology
Kelly E. Lloyd, Louise H. Hall, Lucy Ziegler, Samuel G. Smith
Summary: The study found that 39.5% of respondents reported medium breast cancer worry at baseline, and 21.2% reported high worry. Ethnic minority women and women educated below degree level were more likely to report high worry. However, no significant association was observed between worry and uptake rates.
BREAST CANCER RESEARCH AND TREATMENT
(2021)
Review
Biochemistry & Molecular Biology
Blassan P. George, Rahul Chandran, Heidi Abrahamse
Summary: Cancer chemoprevention involves using external agents to slow down or suppress cancer growth, and the occurrence of global cancer types varies depending on factors such as environmental, lifestyle, and genetic factors. Developed countries can prevent cancer with advanced treatment modalities, while developing countries often see it as a painful death sentence.
Review
Oncology
Xinru Zhou, Yin Jia, Chuanbin Mao, Shanrong Liu
Summary: Small extracellular vesicles (sEVs), such as exosomes, have emerged as crucial targets for liquid biopsy and promising drug delivery vehicles in tumor progression. They can serve as biomarkers for tumor diagnosis and as drug carriers for cancer treatment.
Article
Oncology
Ruochan Chen, Ju Zhu, Xiao Zhong, Jie Li, Rui Kang, Daolin Tang
Summary: The interplay between autophagy and apoptosis plays a crucial role in tumorigenesis and cancer therapy, with HMGB1 serving as a key regulator in these processes.
Article
Oncology
Zongfu Pan, Xixuan Lu, Tong Xu, Jinming Chen, Lisha Bao, Ying Li, Yingying Gong, Yulu Che, Xiaozhou Zou, Zhuo Tan, Ping Huang, Minghua Ge
Summary: This study uncovered the emerging role of HN1 in promoting dedifferentiation of anaplastic thyroid cancer (ATC) cells. HN1 negatively regulated the thyroid differentiation markers and had an inhibitory effect on the transcriptional activation of CTCF, thereby influencing the chromatin accessibility of thyroid differentiation genes.
Article
Oncology
Yi Qin, Shengjun Xiong, Jun Ren, Gautam Sethi
Summary: Autophagy plays an important regulatory role in glioblastoma, and its dysregulation can lead to drug resistance and radioresistance. It also affects stem cell characteristics, overall growth, and metastasis. Therefore, autophagy is a promising target for glioblastoma therapy.
Article
Oncology
Katsuya Nagaoka, Xuewei Bai, Dan Liu, Kevin Cao, Joud Mulla, Chengcheng Ji, Hongze Chen, Muhammad Azhar Nisar, Amalia Bay, William Mueller, Grace Hildebrand, Jin-Song Gao, Shaolei Lu, Hiroko Setoyama, Yasuhito Tanaka, Jack R. Wands, Chiung-Kuei Huang
Summary: This study found that serum 2-OG levels in cholangiocarcinoma patients are associated with the effectiveness of chemotherapy. Patients with progressive disease showed significantly higher levels of serum 2-OG compared to stable disease and partial response patients. The study also revealed that overexpression of ASPH mimics the effects of 2-OG, and knockdown of ASPH improves chemotherapy. Targeting ASPH enhances the effects of chemotherapy by modulating ATM and ATR, two key regulators of DDRs.
