期刊
CANCER LETTERS
卷 292, 期 2, 页码 163-170出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2009.11.020
关键词
Moscatilin; VEGF; bFGF; Endothelial cells; Angiogenesis
类别
资金
- National Science Council of the Republic of China [NSC 96-2628-B-002-109-MY3, NSC 96-2321-B-002-031-MY2]
Attacking angiogenesis is considered an effective strategy for controls the expansion and metastasis of tumors and other related-diseases. The aim of this study was to assess the effects of moscatilin, a bibenzyl derivative, on VEGF and bFGF-induced angiogenesis in cultured human umbilical vein endothelial cells (HUVECs) in vitro and in vivo Moscatilin significantly inhibited growth of lung cancer cell line A549 (NSCLC) and suppressed growth factor-induced neovascularization In addition, VEGF- and bFGF-induced cell proliferation, migration, and tube formation of HUVECs was markedly inhibited by moscatilin Western blotting analysis of cell signaling molecules indicated that moscatilin inhibited ERK1/2, Akt, and eNOS signaling pathways in HUVECs These results suggest that inhibition of angiogenesis by moscatilin may be a major mechanism in cancer therapy (C) 2009 Elsevier Ireland Ltd All rights reserved
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