Article
Virology
Arushi Vats, Neva Skrabar, Giannino Del Sal, Lawrence Banks
Summary: This study demonstrates that knocking down the E6AP gene in cervical cancer cells leads to an increase in phosphorylation of the E6 oncoprotein. The phosphorylation of E6 requires the transcriptional activity of p53 and the presence of the enzyme DNA PK. This study defines a feedback loop where activation of p53 induces phosphorylation of E6, which in turn inhibits p53 transcriptional activity independently of E6's ability to degrade p53.
JOURNAL OF VIROLOGY
(2022)
Article
Medicine, Research & Experimental
Weiyi Zhang, Qian Che, Hongsheng Tan, Xin Qi, Dehai Li, Tianjiao Zhu, Ming Liu
Summary: Researchers isolated a novel antimycin alkaloid called antimycin A2c (AE) from a marine-derived Streptomyces sp. THS-55 and determined its chemical structure through extensive spectra. They also investigated the specific mechanism of AE in HPV-infected cervical cancer.
Article
Genetics & Heredity
Yusuf M. Idres, Alan J. Lai, Nigel A. J. McMillan, Adi Idris
Summary: Increasing the bioavailability of p53 may be a promising therapeutic approach for the treatment of HPV-driven cancers.
Article
Biochemistry & Molecular Biology
Noor Nabilah Talik Sisin, Aaron Raphael Kong, Hisham Atan Edinur, Noor Izani Noor Jamil, Nor Fazila Che Mat
Summary: The methanol extract of Oroxylum indicum leaves effectively inhibits the proliferation of SiHa cervical cancer cells by suppressing the expression of E6 and E7 viral oncoproteins and upregulating the tumor suppressor genes p53 and pRb. Combinatorial treatment with OI extract and gossypin flavonoid restores the function of p53 and pRb. OI extract treatment in siRNA-transfected cells further suppresses E6/E7 expression and upregulates p53 and pRb proteins.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Alejandra Garcia, Giovanna Maldonado, Jose L. Gonzalez, Yuri Svitkin, David Cantu, Alejandro Garcia-Carranca, Nahum Sonenberg, Greco Hernandez
Summary: HPV infection is a necessary factor for the development of cervical cancer, and viral oncoproteins E6 and E7 play central roles in the carcinogenic process. Studies have shown that certain HPV subtypes use unique mechanisms for translating E6/E7 in cervical tumors, shedding light on the mechanism of cancer development.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Genetics & Heredity
Abolfazl Kooti, Haniyeh Abuei, Ali Farhadi, Abbas Behzad-Behbahani, Maryam Zarrabi
Summary: Overexpression of ATF3 increases apoptosis in HPV-18-infected HeLa cells, but has no significant effect on the levels of p53 and E6. ATF3 acts as a tumor suppressor through a p53-independent pathway in HPV18-related cervical cancer.
Article
Oncology
Garima Singh, Sonika Kumari Sharma, Samarendra Kumar Singh
Summary: MicroRNAs play an important role in regulating cell cycle and other cellular processes. This study reveals that miR-34a can suppress HPV E6 protein and destabilize Cdt2/DTL protein level in HPV-infected cervical cancer cells, leading to the suppression of cell proliferation, invasion and migration capabilities of these cells. The findings suggest the potential of miR-34a as a specific therapy for cervical cancer treatment.
Article
Virology
Marcel Chris Conrady, Irina Suarez, Gergo Gogl, Desiree Isabella Frecot, Anna Bonhoure, Camille Kostmann, Alexandra Cousido-Siah, Andre Mitschler, JiaWen Lim, Murielle Masson, Thomas Iftner, Frank Stubenrauch, Gilles Trave, Claudia Simon
Summary: The study compared the structures and efficiency of ternary complex formation between oncogenic E6 proteins of closely related high-risk HPV31 and HPV16 with their cellular targets p53 and E6AP. Despite high structural similarity, 31 E6 showed an overall lower binding affinity than 16 E6, aligning with the observed lower p53 degradation potential of 31 E6.
JOURNAL OF VIROLOGY
(2021)
Article
Chemistry, Multidisciplinary
Xiyun Ye, Peiyuan Zhang, Jason Tao, John C. K. Wang, Amirhossein Mafi, Nathalie M. Grob, Anthony J. Quartararo, Hannah T. Baddock, Leanne J. G. Chan, Fiona E. McAllister, Ian Foe, Andrei Loas, Dan L. Eaton, Qi Hao, Aaron H. Nile, Bradley L. Pentelute
Summary: In this study, a covalent peptide inhibitor called reactide was designed to inhibit HPV-mediated degradation of p53 by targeting cysteine 58 in HPV16 E6. This reactide provides a starting point for the development of covalent peptidomimetic inhibitors against HPV-driven cancers.
Review
Oncology
Chichao Xia, Sile Li, Teng Long, Zigui Chen, Paul K. S. Chan, Siaw Shi Boon
Summary: This review provides an updated overview of cancer-causing HPV genotypes in East, Southeast, and South Asia, highlighting differences in detection and treatment methods compared to other regions. The article also points out the lack of study in certain areas and the challenges faced in HPV research.
Article
Biochemistry & Molecular Biology
Chong Liang, Chonglun Zhang, Yinlin Zhuo, Baocheng Gong, Weizhuo Xu, Guogang Zhang
Summary: In this study, 12 phenanthrene compounds were extracted and isolated from Dendrobium officinale, and their cytotoxic activities against cancer cells were evaluated. Compound 5 showed significant cytotoxic effects and could be a potential drug candidate for cervical cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Natasa Nikolic, Branka Basica, Aljosa Mandic, Nela Surla, Vera Gusman, Deana Medic, Tamas Petrovic, Mirjana Strbac, Vladimir Petrovic
Summary: Cervical cancer caused by persistent infection with HR HPV genotypes is a significant cause of death among women aged 15 to 44 in Serbia. The expression of E6 and E7 HPV oncogenes can be used as a biomarker for diagnosing high-grade squamous intraepithelial lesions (HSIL). This study aimed to evaluate the diagnostic potential of HPV mRNA and DNA tests for HSIL.
Article
Chemistry, Multidisciplinary
Feng Chen, Hong-Mei Wang, Ling-Qi Kong, Qin-Hua Chen, Li-Na Ke, He-Liu Dai, Xiao-Hua Zeng
Summary: Heterocyclic compounds, such as pyrrolidone, have been widely used and studied in various fields. In this study, a new fluorine-containing rhopaladins' analog called RPDPD was synthesized and evaluated for its anti-tumor activity in vitro. The results showed that RPDPD inhibited the proliferation of HeLa cells and induced apoptosis, possibly through the inhibition of E6 and E7 mRNA expressions and the modulation of the TIMP3/MMP3 signaling pathway.
FRONTIERS IN CHEMISTRY
(2022)
Article
Obstetrics & Gynecology
Linn Woelber, Katharina Prieske, Christine Eulenburg, Leticia Oliveira-Ferrer, Nikolaus de Gregorio, Ruediger Klapdor, Matthias Kalder, Iona Braicu, Sophie Fuerst, Maximilian Klar, Hans-Georg Strauss, Matthias Beckmann, Werner Meier, Atanas Ignatov, Alexander Mustea, Julia Jueckstock, Georg Schmidt, Dirk Bauerschlag, Martin Hellriegel, Ulrich Canzler, Karl Ulrich Petry, Stefan Kommoss, Peer Hantschmann, Martin Heubner, Sven Mahner, Eike Burandt
Summary: This study aimed to investigate the role of human papillomavirus and p53 status in vulvar squamous cell carcinoma. It found that p16 overexpression is associated with improved prognosis, while p53 positivity is linked to adverse outcomes. A clinically relevant third subgroup of vulvar squamous cell carcinoma with a p53-/p16- phenotype showing an intermediate prognosis was identified and needs further characterization.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Cell Biology
Jinshun Zhu, Saidu Kamara, Qi Wang, Yanru Guo, Qingfeng Li, Linlin Wang, Jingjing Chen, Qianqian Du, Wangqi Du, Shao Chen, Shanli Zhu, Jun Chen, Maoping Chu, Lifang Zhang
Summary: This study identified three novel HPV16 E6-binding affibody molecules, which showed high binding affinity and specificity for HPV16 E6, selectively reducing the viability and proliferation of HPV16-positive cells. The combination of these affibody molecules with another targeting HPV16 E7 resulted in a more potent inhibition of cell proliferation, primarily through the induction of cell apoptosis and senescence. These findings suggest a potential rational strategy for molecular imaging and targeted therapy in HPV16-positive preneoplastic and neoplastic lesions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Virology
Eui Ho Kim, Brandon Neldner, Jingang Gui, Ruth W. Craig, M. Suresh
Article
Immunology
Eui Ho Kim, Jeremy A. Sullivan, Erin H. Plisch, Melba Marie Tejera, Anna Jatzek, Kwan Yong Choi, M. Suresh
JOURNAL OF IMMUNOLOGY
(2012)
Article
Immunology
Eui Ho Kim, David J. Gasper, Song Hee Lee, Erin Hemmila Plisch, John Svaren, M. Suresh
JOURNAL OF IMMUNOLOGY
(2014)
Article
Immunology
Melba Marie Tejera, Eui Ho Kim, Jeremy A. Sullivan, Erin H. Plisch, M. Suresh
JOURNAL OF IMMUNOLOGY
(2013)
Article
Virology
Jeremy A. Sullivan, Eui Ho Kim, Erin H. Plisch, M. Suresh
JOURNAL OF VIROLOGY
(2012)
Review
Immunology
Eui Ho Kim, M. Suresh
FRONTIERS IN IMMUNOLOGY
(2013)
Review
Biochemistry & Molecular Biology
Eui Ho Kim, Sing-Wai Wong, Jennifer Martinez
CELL DEATH AND DIFFERENTIATION
(2019)
Article
Cell Biology
Matthew Charles Woodruff, Eui Ho Kim, Wei Luo, Bali Pulendran
Article
Biochemistry & Molecular Biology
Sing-Wai Wong, Bo-Wen Huang, Xiangxiang Hu, Eui Ho Kim, Joseph P. Kolb, Ricardo J. Padilla, Peng Xue, Lufei Wang, Thomas H. Oguin, Patricia A. Miguez, Henry C. Tseng, Ching-Chang Ko, Jennifer Martinez
CELL DEATH AND DIFFERENTIATION
(2020)
Article
Biology
Eui Ho Kim, Matthew C. Woodruff, Lilit Grigoryan, Barbara Maier, Song Hee Leel, Pratushya Mandel, Mario Cortese, Muktha S. Natrajan, Rajesh Ravindran, Huailiang Ma, Miriam Merad, Alexander D. Gitlin, Edward S. Mocarski, Joshy Jacob, Bali Pulendran
Article
Multidisciplinary Sciences
Song Hee Lee, Eui Ho Kim, Justin T. O'neal, Gordon Dale, David J. Holthausen, James R. Bowen, Kendra M. Quicke, Ioanna Skountzou, Shyla Gopal, Sanil George, Jens Wrammert, Mehul S. Suthar, Joshy Jacob
Summary: The Zika virus is a serious health threat transmitted through mosquito bites, sexual contact, and blood transfusion. It can cause fetal abnormalities and Guillain-Barre syndrome in adults. There are currently no vaccines or antiviral drugs available for humans.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Dong-In Kim, Ji-Hun Kang, Eui-Ho Kim, Young-Jin Seo
Summary: The study demonstrates that KIF11 inhibitors can effectively attenuate viral cytopathic effect and suppress viral replication, providing a new therapeutic target for the prevention and treatment of influenza virus infections.
MOLECULAR & CELLULAR TOXICOLOGY
(2021)
Letter
Infectious Diseases
So Yun Lim, Ji Yeun Kim, Jin Ah Lee, Ji-Soo Kwon, Ji Young Park, Hye Hee Cha, Mi Hyun Suh, Hyun Jung Lee, Hyeonju Kim, Seungtaek Kim, Seongman Bae, Jiwon Jung, Eui Ho Kim, Youngmee Jee, Sung-Han Kim
JOURNAL OF INFECTION
(2022)
Review
Virology
Sun Min Lee, Paul Kim, Jinsuh You, Eui Ho Kim
Summary: DAMPs and cell death pathways play crucial roles in vaccine-induced immunity, activating the immune system to combat pathogenic infection and cell death. New strategies are actively being explored to enhance immunogenicity through targeting these pathways.
Article
Plant Sciences
Yong-Hyun Joo, Yeong-Geun Lee, Younghyun Lim, Hoyeon Jeon, Eui Ho Kim, Joongyeon Choi, Woojae Hong, Hyelin Jeon, Michael Ahrweiler, Hyunggun Kim, Se Chang Kang, Young-Jin Seo
Summary: The study found that the extract of Elaeocarpus sylvestris has strong antiviral activity against influenza A virus infection, which could lead to the development of new plant-based medicine to treat influenza virus infection.
Review
Oncology
Xinru Zhou, Yin Jia, Chuanbin Mao, Shanrong Liu
Summary: Small extracellular vesicles (sEVs), such as exosomes, have emerged as crucial targets for liquid biopsy and promising drug delivery vehicles in tumor progression. They can serve as biomarkers for tumor diagnosis and as drug carriers for cancer treatment.
Article
Oncology
Ruochan Chen, Ju Zhu, Xiao Zhong, Jie Li, Rui Kang, Daolin Tang
Summary: The interplay between autophagy and apoptosis plays a crucial role in tumorigenesis and cancer therapy, with HMGB1 serving as a key regulator in these processes.
Article
Oncology
Zongfu Pan, Xixuan Lu, Tong Xu, Jinming Chen, Lisha Bao, Ying Li, Yingying Gong, Yulu Che, Xiaozhou Zou, Zhuo Tan, Ping Huang, Minghua Ge
Summary: This study uncovered the emerging role of HN1 in promoting dedifferentiation of anaplastic thyroid cancer (ATC) cells. HN1 negatively regulated the thyroid differentiation markers and had an inhibitory effect on the transcriptional activation of CTCF, thereby influencing the chromatin accessibility of thyroid differentiation genes.
Article
Oncology
Yi Qin, Shengjun Xiong, Jun Ren, Gautam Sethi
Summary: Autophagy plays an important regulatory role in glioblastoma, and its dysregulation can lead to drug resistance and radioresistance. It also affects stem cell characteristics, overall growth, and metastasis. Therefore, autophagy is a promising target for glioblastoma therapy.
Article
Oncology
Katsuya Nagaoka, Xuewei Bai, Dan Liu, Kevin Cao, Joud Mulla, Chengcheng Ji, Hongze Chen, Muhammad Azhar Nisar, Amalia Bay, William Mueller, Grace Hildebrand, Jin-Song Gao, Shaolei Lu, Hiroko Setoyama, Yasuhito Tanaka, Jack R. Wands, Chiung-Kuei Huang
Summary: This study found that serum 2-OG levels in cholangiocarcinoma patients are associated with the effectiveness of chemotherapy. Patients with progressive disease showed significantly higher levels of serum 2-OG compared to stable disease and partial response patients. The study also revealed that overexpression of ASPH mimics the effects of 2-OG, and knockdown of ASPH improves chemotherapy. Targeting ASPH enhances the effects of chemotherapy by modulating ATM and ATR, two key regulators of DDRs.
