Review
Biochemistry & Molecular Biology
Kaiming Li, Mark F. van Delft, Grant Dewson
Summary: Apoptotic cell death plays important roles in physiological and pathological processes, especially in cancer therapy and neurodegenerative diseases. Inhibitors of apoptosis have emerged as a potential strategy to combat pathological cell loss, serving as important research tools due to their mechanisms of action, advantages, and limitations.
Article
Parasitology
Shanming Hu, Yanan Wang, Zhengmao Xu, Yongzhi Zhou, Jie Cao, Houshuang Zhang, Jinlin Zhou
Summary: The study found that the transcription levels of the RhBax gene in ticks increase significantly at all developmental stages, while the transcription levels of both RhBcl-2 and RhBax increase more significantly in the female salivary glands. Inhibiting RhBcl-2 expression significantly inhibited tick feeding, while interference with RhBax had no effect on tick feeding.
PARASITES & VECTORS
(2021)
Review
Cell Biology
Rebar N. Mohammed, Mohsen Khosravi, Heshu Sulaiman Rahman, Ali Adili, Navid Kamali, Pavel Petrovich Soloshenkov, Lakshmi Thangavelu, Hossein Saeedi, Navid Shomali, Rozita Tamjidifar, Alireza Isazadeh, Ramin Aslaminabad, Morteza Akbari
Summary: Balanced cell death and survival pathways, including anastasis, play a critical role in cell development and homeostasis. Anastasis is a natural cell recovery pathway that promotes the survival of damaged or tumor cells, and contributes to the development of malignancy and drug resistance.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Biochemistry & Molecular Biology
Anna Santarsiero, Ilaria Pappalardo, Gabriella Margherita Rosa, Isabella Pisano, Stefano Superchi, Paolo Convertini, Simona Todisco, Patrizia Scafato, Vittoria Infantino
Summary: Hepatocellular carcinoma (HCC) is the most common type of liver cancer and a significant cause of cancer-related deaths. In this study, a newly synthesized chalcone ETTC showed cytotoxic activity and induced apoptosis in HCC cells through the activation of the intrinsic pathway of apoptosis and mitochondrial targeting. These findings suggest the potential antitumor effect of ETTC in HCC.
Article
Chemistry, Medicinal
Dawon Bae, Prakash Chaudhary, Jae-Hui Been, Jaya Gautam, Jisu Lee, Sajita Shah, Euijung Kim, Hyunji Lee, Tae-gyu Nam, Byeong-Seon Jeong, Jung-Ae Kim
Summary: A series of 3-arylidene-4,6-dimethyl-5-hydroxy-7-azaoxindole compounds with various functional groups were synthesized and evaluated for their antitumor activity. Compound 6-15, containing a quinoline moiety, exhibited stronger cytotoxicity than sunitinib against multiple cancer cell lines. However, it showed weaker inhibitory activity against receptor tyrosine kinases compared to sunitinib. Compound 6-15 suppressed the expression of Gas6, the ligand of Axl, and demonstrated promising anticancer effects both in vitro and in vivo.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Martina Messner, Melanie M. Mandl, Mathias W. Hackl, Till Reinhardt, Maximilian A. Ardelt, Karolina Szczepanowska, Julian E. Fraedrich, Jens Waschke, Irmela Jeremias, Anja Fux, Matthias Stahl, Angelika M. Vollmar, Stephan A. Sieber, Johanna Pachmayr
Summary: The bacterial ClpXP inhibitor showed potential anti-cancer activity against the human ClpXP protease complex and affected mitochondrial function, leading to cell death.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Katarzyna Ratajczak, Natalia Glatzel-Plucinska, Katarzyna Ratajczak-Wielgomas, Katarzyna Nowinska, Sylwia Borska
Summary: Resveratrol may have anticarcinogenic effects by inhibiting human pancreatic cancer cell proliferation and affecting the levels of Bcl-2 proteins. However, its activity is specific to each tested cell line, with the most significant changes observed in the mitoxantrone-resistant cells.
Article
Biochemistry & Molecular Biology
Qiling Tang, Hongce Chen, Zihao Mai, Han Sun, LingJun Xu, Guihao Wu, Zhuang Tu, Xuecheng Cheng, Xiaoping Wang, Tongsheng Chen
Summary: Abivertinib (AC) is a novel epidermal growth factor receptor tyrosine kinase inhibitor that exhibits highly efficient antitumor activity. This study demonstrates that AC can induce both reactive oxygen species (ROS)-dependent apoptosis and ferroptosis in tumor cells. The Bim- and Bax-mediated mitochondrial pathways play a dominant role in AC-induced ferroptosis and apoptosis.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Yang Yang, Yongjian Wu, Xiaojun Meng, Zhiying Wang, Muhammad Younis, Ye Liu, Peihui Wang, Xi Huang
Summary: Research reveals that SARS-CoV-2 membrane (M) protein can induce apoptosis in lung epithelial cells, exacerbating lung injury. The M protein stabilizes B-cell lymphoma 2 (BCL-2) ovarian killer (BOK), inhibiting its ubiquitination and promoting BOK translocation to the mitochondria, leading to apoptosis. This discovery may provide new targets for COVID-19 treatment.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Agriculture, Dairy & Animal Science
Reshma S. Raj, D. N. Das, S. Mondal, M. Ashokan, Lakshmi Narasimha Thota, T. Karuthadurai, Nikhil Kumar J. Tej, Kerekoppa P. Ramesha
Summary: This study aimed to analyze the expression of pro-apoptotic BAX and anti-apoptotic BCL-2 genes on lactation performance in Bos indicus and HF crossbred cows during early lactation. The results showed that BCL-2 gene promotes milk production while BAX gene opposes milk production. Bos indicus cows are more sensitive to apoptosis compared to HF crossbreds.
ANIMAL BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Qiaohong Xu, Fang Cui, Xiaodong Li, Nan Wang, Yingrui Gao, Shiping Yin, Fangdi Hu
Summary: Dangshen, a medicinal and edible plant, has been found to have protective effects on gastric mucosa. It can improve chronic non-atrophic gastritis by enhancing antioxidant capacity, suppressing inflammatory responses, and reducing cell apoptosis. This study reveals the potential value of Dangshen in the treatment of gastric diseases.
Article
Biochemistry & Molecular Biology
Masoumeh Firouzamandi, Marzie Hejazy, Alaleh Mohammadi, Amir Ali Shahbazfar, Roghayeh Norouzi
Summary: This study aimed to investigate the toxicological effects of nano-SiO2 through apoptotic factors. The results showed that nano-SiO2 at doses of 300 and 900 mg/kg/day resulted in overexpression of BAX and Caspase3 genes in the liver and kidney. At a dose of 600 mg/kg/day, the Bcl-2 gene was up-regulated in the liver and kidney. Histopathological examination revealed hyperemia in the kidney and lungs at a dose of 600 mg/kg/day, and scattered necrosis and hyperemia in the liver at a dose of 900 mg/kg/day. Therefore, caution should be exercised regarding the use of nano-SiO2 as an additive and food packaging material due to its deleterious effects.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Endocrinology & Metabolism
Haopeng Xu, Yi Xia, Juan Qin, Jie Xu, Chongyan Li, Yan Wang
Summary: The study demonstrated that LIPUS can improve POF induced by VCD by promoting follicular development, increasing sex hormone secretion, inhibiting excessive follicular atresia, and GCs apoptosis, possibly through increasing Bcl-2 protein expression and decreasing Bax expression in the ovaries.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Article
Oncology
Zeinab Babaei, Mojtaba Panjehpour, Hadi Parsian, Mahmoud Aghaei
Summary: The study found that SAR131675 can inhibit the proliferation of human endothelial cells and induce cell apoptosis. The results also indicated that SAR131675 induced apoptosis by affecting mitochondrial membrane potential, generating reactive oxygen species, and regulating the expression of Bcl-2/Bax/Cyto c, leading to the inhibition of cancer cell proliferation.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2022)
Article
Oncology
Claudie Bosc, Estelle Saland, Aurelie Bousard, Noemie Gadaud, Marie Sabatier, Guillaume Cognet, Thomas Farge, Emeline Boet, Mathilde Gotanegre, Nesrine Aroua, Pierre-Luc Mouchel, Nathaniel Polley, Clement Larrue, Eleonore Kaphan, Muriel Picard, Ambrine Sahal, Latifa Jarrou, Marie Tosolini, Florian Rambow, Florence Cabon, Nathalie Nicot, Laura Poillet-Perez, Yujue Wang, Xiaoyang Su, Quentin Fovez, Jerome Kluza, Rafael Jose Arguello, Celine Mazzotti, Herve Avet-Loiseau, Francois Vergez, Jerome Tamburini, Jean-Jacques Fournie, Ing S. Tiong, Andrew H. Wei, Tony Kaoma, Jean-Christophe Marine, Christian Recher, Lucille Stuani, Carine Joffre, Jean-Emmanuel Sarry
Summary: Therapy resistance in AML is linked to high mitochondrial oxidative phosphorylation identified by MitoScore. Targeting mitochondrial metabolism can delay AML relapse, highlighting the central role of mitochondrial adaptation in AML therapy.
Review
Oncology
Xinru Zhou, Yin Jia, Chuanbin Mao, Shanrong Liu
Summary: Small extracellular vesicles (sEVs), such as exosomes, have emerged as crucial targets for liquid biopsy and promising drug delivery vehicles in tumor progression. They can serve as biomarkers for tumor diagnosis and as drug carriers for cancer treatment.
Article
Oncology
Ruochan Chen, Ju Zhu, Xiao Zhong, Jie Li, Rui Kang, Daolin Tang
Summary: The interplay between autophagy and apoptosis plays a crucial role in tumorigenesis and cancer therapy, with HMGB1 serving as a key regulator in these processes.
Article
Oncology
Zongfu Pan, Xixuan Lu, Tong Xu, Jinming Chen, Lisha Bao, Ying Li, Yingying Gong, Yulu Che, Xiaozhou Zou, Zhuo Tan, Ping Huang, Minghua Ge
Summary: This study uncovered the emerging role of HN1 in promoting dedifferentiation of anaplastic thyroid cancer (ATC) cells. HN1 negatively regulated the thyroid differentiation markers and had an inhibitory effect on the transcriptional activation of CTCF, thereby influencing the chromatin accessibility of thyroid differentiation genes.
Article
Oncology
Yi Qin, Shengjun Xiong, Jun Ren, Gautam Sethi
Summary: Autophagy plays an important regulatory role in glioblastoma, and its dysregulation can lead to drug resistance and radioresistance. It also affects stem cell characteristics, overall growth, and metastasis. Therefore, autophagy is a promising target for glioblastoma therapy.
Article
Oncology
Katsuya Nagaoka, Xuewei Bai, Dan Liu, Kevin Cao, Joud Mulla, Chengcheng Ji, Hongze Chen, Muhammad Azhar Nisar, Amalia Bay, William Mueller, Grace Hildebrand, Jin-Song Gao, Shaolei Lu, Hiroko Setoyama, Yasuhito Tanaka, Jack R. Wands, Chiung-Kuei Huang
Summary: This study found that serum 2-OG levels in cholangiocarcinoma patients are associated with the effectiveness of chemotherapy. Patients with progressive disease showed significantly higher levels of serum 2-OG compared to stable disease and partial response patients. The study also revealed that overexpression of ASPH mimics the effects of 2-OG, and knockdown of ASPH improves chemotherapy. Targeting ASPH enhances the effects of chemotherapy by modulating ATM and ATR, two key regulators of DDRs.