Article
Oncology
Lili Zhang, Huixiao Chen, Fengxi He, Shiqian Zhang, Aihua Li, Aifeng Zhang, Anqi Zhang
Summary: miR-320a plays an important role in ovarian cancer progression and infiltration, promoting the proliferation, migration, and invasion of EOC cells by targeting RASSF8.
FRONTIERS IN ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Joanna Lopacinska-Jorgensen, Douglas V. N. P. Oliveira, Guy Wayne Novotny, Claus K. Hogdall, Estrid V. Hogdall
Summary: Ovarian cancer (OC) is the eighth leading cause of cancer-related death among females worldwide. MicroRNAs (miRNAs) may play an important role in the development of ovarian cancer, but their underlying mechanisms are still unclear, and there is a lack of consensus on existing methodologies. The study identified certain miRNA-mRNA interaction pairs that may be associated with the overall survival of ovarian cancer patients, indicating the potential for revealing miRNA-mRNA signatures relevant to EOC.
Article
Endocrinology & Metabolism
Jing-min Yu, Min-yi Yang, Xia Zhao, Jing-hui Hu
Summary: This study investigated the relationship between OGN expression levels and the extent of ovarian cancer growth and metastasis. The results showed that overexpression of OGN inhibited the migration and invasion of SKOV3 cells. In a mouse model of lung metastasis of ovarian cancer, OGN overexpression combined with cisplatin therapy significantly prolonged survival and inhibited tumor growth. Thus, OGN may be an important potential target for the prediction and control of ovarian cancer metastasis.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Oncology
Yali Fan, Jiandong Wang, Ziwei Fang, Stuart R. Pierce, Lindsay West, Allison Staley, Katherine Tucker, Yajie Yin, Wenchuan Sun, Weimin Kong, Varun Prabhu, Joshua E. Allen, Chunxiao Zhou, Victoria L. Bae-Jump
Summary: ONC201 shows promising anti-tumor potential in ovarian cancer by suppressing cell proliferation and inducing apoptosis through multiple pathways. It also inhibits adhesion and invasion in cancer cells. Additionally, it can suppress tumor growth and decrease serum VEGF production, which is accelerated by obesity.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Chang Xiong, Zhongfeng Sun, Jinjin Yu, Yaying Lin
Summary: In gynecologic malignancies, ovarian cancer is the leading cause of death due to lack of sensitive tumor markers, often presenting at an advanced stage. This study found that EXOSC4 is significantly elevated in EOC tissues and cell lines, and its knockdown inhibits proliferation, migration, and invasion by suppressing the Wnt pathway. EXOSC4 shows promise as a novel biomarker and molecular target in EOC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Jun-Hong Hu, Hong-Na Tang, Yu-Hang Wang
Summary: This study reveals that CAFs-exo promotes EMT progression and chemoresistance in CRC cells by secreting LINC00355. Further investigation demonstrates that CAFs-exo-derived LINC00355 enhances the expression of CRKL by inhibiting miR-34b-5p, thereby enhancing chemoresistance and promoting EMT in CRC cells.
CANCER GENE THERAPY
(2023)
Article
Medicine, Research & Experimental
Jiangtao Yu, Xiaoli Hu, Xiuxiu Chen, Qiangyong Zhou, Qi Jiang, Zhengzheng Shi, Haiyan Zhu
Summary: CNOT7 plays an important role in biological processes and has potential for treating malignant tumors. This study aimed to investigate the functions and mechanism of CNOT7 in ovarian cancer. Results showed that CNOT7 overexpression in A2780 and SKOV3 cells could be partially or completely eliminated by treatment with the AKT inhibitor LY294002.
Article
Cell Biology
Jing Cai, Lanqing Gong, Guodong Li, Jing Guo, Xiaoqing Yi, Zehua Wang
Summary: Poor prognosis of ovarian cancer is mainly due to metastasis, with ascites-derived exosomes playing a role in promoting metastasis through epithelial-mesenchymal transition. The key microRNA miR-6780b-5p in ADEs facilitates cancer metastasis by promoting EMT in ovarian cancer cells, indicating a potential mechanism for ovarian cancer progression.
CELL DEATH & DISEASE
(2021)
Article
Medicine, Research & Experimental
Tianshui Sun, Fangfang Bi, Zhuonan Liu, Qing Yang
Summary: In ovarian cancer patients, TMEM119 is overexpressed and associated with poor survival. Experimental results indicate TMEM119 promotes proliferation, invasion, and migration of ovarian cancer cells. Additionally, TMEM119 may exert oncogenic effects by regulating PDGFRB expression and activating the PI3K/AKT signaling pathway.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Cell Biology
Huanhuan Deng, Leihong Deng, Haichao Chao, Zhaojun Yu, Jianbiao Huang, Zhen Song, Lifen Peng, Tao Zeng
Summary: Bladder cancer (BLCA) is a common cancer with high mortality ranking 9th. The relationship between autophagy and epithelial to mesenchymal transition (EMT) in BLCA is poorly understood. This study identified the autophagy-related gene RAB14 and demonstrated its promotion of EMT, migration, and invasion in bladder cancer cells through the Akt-associated autophagic pathway. Knocking down RAB14 inhibited EMT and autophagy in T24 cells, and RAB14 levels were positively correlated with key autophagy genes LC3B and Beclin1. These findings suggest the potential role of RAB14 in BLCA progression.
CELL DEATH DISCOVERY
(2023)
Article
Reproductive Biology
Qiao Ping Xu, Kui Deng, Zhen Zhang, Hongkai Shang
Summary: Ovarian cancer is a growing global disease, and there is an urgent need for chemotherapy and targeted therapy. SLFN5 plays an important role in malignancy, but its specific function in ovarian cancer cells is still unclear. This study suggests that SLFN5 expression is related to the progression and malignancy of ovarian cancer, and its silencing has a significant inhibitory effect on the invasion and metastasis ability of ovarian cancer cells. Therefore, SLFN5 may serve as a potential target for future drug development in the treatment of ovarian cancer.
JOURNAL OF OVARIAN RESEARCH
(2023)
Article
Oncology
Katherine Tucker, Yajie Yin, Stuart-Allison Staley, Ziyi Zhao, Ziwei Fang, Yali Fan, Xin Zhang, Hongyan Suo, Wenchuan Sun, Varun Vijay Prabhu, Joshua E. Allen, Chunxiao Zhou, Victoria L. Bae-Jump
Summary: ONC206, a chemically modified derivative of ONC201, is a potent inhibitor of cell proliferation and shows anti-tumorigenic effects in ovarian cancer. It has the potential to be an important therapeutic option for ovarian cancer treatment.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Shanshan Wang, Qian Hao, Jiajia Li, Yajie Chen, Hua Lu, Xiaohua Wu, Xiang Zhou
Summary: DTX3 plays a promoting role in ovarian cancer by enhancing the activity of mutant p53, and its expression is correlated with the expression of mutant p53 target genes and associated with unfavorable prognosis.
Article
Oncology
Guangxu Xu, Weimin Kong, Ziwei Fang, Yali Fan, Yajie Yin, Stephanie A. Sullivan, Arthur-Quan Tran, Leslie H. Clark, Wenchuan Sun, Tianran Hao, Luyu Zhao, Chunxiao Zhou, Victoria L. Bae-Jump
Summary: The natural product asparagus officinalis exhibits anti-tumorigenic and anti-metastatic effects on serous ovarian cancer cells by decreasing cell viability, inducing apoptosis, and reducing adhesion and invasion abilities. Additionally, it shows synergistic anti-proliferative activity when combined with paclitaxel, and inhibits tumor growth and reduces serum levels of VEGF in a mouse model of ovarian cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Hangyu Zhang, Changgang Liu, Xinbo Wang, Yongfang Wang, Jie Zheng
Summary: SCARA5 expression is downregulated in gastric cancer, associated with promoter methylation, aggressive clinicopathological characteristics, and poor prognosis. Overexpression of SCARA5 inhibits the growth and migration of GC cells, potentially serving as a biomarker for diagnosis and therapeutic target.
Review
Oncology
Xinru Zhou, Yin Jia, Chuanbin Mao, Shanrong Liu
Summary: Small extracellular vesicles (sEVs), such as exosomes, have emerged as crucial targets for liquid biopsy and promising drug delivery vehicles in tumor progression. They can serve as biomarkers for tumor diagnosis and as drug carriers for cancer treatment.
Article
Oncology
Ruochan Chen, Ju Zhu, Xiao Zhong, Jie Li, Rui Kang, Daolin Tang
Summary: The interplay between autophagy and apoptosis plays a crucial role in tumorigenesis and cancer therapy, with HMGB1 serving as a key regulator in these processes.
Article
Oncology
Zongfu Pan, Xixuan Lu, Tong Xu, Jinming Chen, Lisha Bao, Ying Li, Yingying Gong, Yulu Che, Xiaozhou Zou, Zhuo Tan, Ping Huang, Minghua Ge
Summary: This study uncovered the emerging role of HN1 in promoting dedifferentiation of anaplastic thyroid cancer (ATC) cells. HN1 negatively regulated the thyroid differentiation markers and had an inhibitory effect on the transcriptional activation of CTCF, thereby influencing the chromatin accessibility of thyroid differentiation genes.
Article
Oncology
Yi Qin, Shengjun Xiong, Jun Ren, Gautam Sethi
Summary: Autophagy plays an important regulatory role in glioblastoma, and its dysregulation can lead to drug resistance and radioresistance. It also affects stem cell characteristics, overall growth, and metastasis. Therefore, autophagy is a promising target for glioblastoma therapy.
Article
Oncology
Katsuya Nagaoka, Xuewei Bai, Dan Liu, Kevin Cao, Joud Mulla, Chengcheng Ji, Hongze Chen, Muhammad Azhar Nisar, Amalia Bay, William Mueller, Grace Hildebrand, Jin-Song Gao, Shaolei Lu, Hiroko Setoyama, Yasuhito Tanaka, Jack R. Wands, Chiung-Kuei Huang
Summary: This study found that serum 2-OG levels in cholangiocarcinoma patients are associated with the effectiveness of chemotherapy. Patients with progressive disease showed significantly higher levels of serum 2-OG compared to stable disease and partial response patients. The study also revealed that overexpression of ASPH mimics the effects of 2-OG, and knockdown of ASPH improves chemotherapy. Targeting ASPH enhances the effects of chemotherapy by modulating ATM and ATR, two key regulators of DDRs.