Review
Biochemistry & Molecular Biology
Ewa Brzozowska, Sameer Deshmukh
Summary: Integrins are crucial for cell adhesion, migration, and positioning. Studies have shown that the expression levels of Integrin αVβ6 are closely related to malignant diseases and patient prognosis. It plays a significant role in cancer progression and the activation of transforming growth factor β(TGF-β). While essential for normal function in healthy individuals, it can also be a target for cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Guixi Zheng, Hakim Bouamar, Matyas Cserhati, Carla R. Zeballos, Isha Mehta, Habil Zare, Larry Broome, Ruolei Hu, Zhao Lai, Yidong Chen, Francis E. Sharkey, Meenakshi Rani, Glenn A. Halff, Francisco G. Cigarroa, Lu-Zhe Sun
Summary: The study found that ITGA6 is upregulated in HCC tumors and has a malignant promoting role in HCC cells through integrin alpha 6 beta 4 complex. Thus, integrin alpha 6 beta 4 may be a therapeutic target for treating HCC patients.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Medicine, Research & Experimental
Jingyun Ren, Shiyu Zhu, Guojin Zhang, Xiaoyue Tan, Ling Qiu, Jianguo Lin, Lei Jiang
Summary: In this study, a PET probe named 68Ga-DOTA-R01-MG was developed for imaging alpha v beta 6-positive lung cancer, which demonstrated excellent stability and specific binding to the target. The probe showed rapid and good tumor uptake and clearance in animal models, indicating its potential as a promising PET tracer for imaging alpha v beta 6-positive lung cancer.
MOLECULAR PHARMACEUTICS
(2022)
Article
Chemistry, Applied
Suresh Sulekha Dhanisha, Sudarsanan Drishya, Chandrasekharan Guruvayoorappan
Summary: In this study, macrophage membrane-coated liposome-based biomimetic nanoparticles were developed to improve the in vivo bioavailability of Naringenin (NG). The nanoparticles exhibited good biocompatibility, stability, and pH-responsive drug release kinetics, leading to higher cellular uptake in vitro. The anti-metastatic efficacy of NG-loaded biomimetic nanoparticles was confirmed in experimental models, indicating its potential for reducing metastatic colonies in the lungs.
Article
Oncology
Mark Sutherland, Andrew Gordon, Fatemah O. F. O. Al-Shammari, Adam Throup, Amy Cilia La Corte, Helen Philippou, Steven D. Shnyder, Laurence H. Patterson, Helen M. Sheldrake
Summary: This study presents a new ligand-mimetic beta 3 integrin antagonist that exhibits high activity against alpha v beta 3 and moderate affinity for alpha IIb beta 3, suggesting a new approach to integrin targeting in cancer.
Article
Oncology
Marius Kemper, Alina Schiecke, Hanna Maar, Sergey Nikulin, Andrey Poloznikov, Vladimir Galatenko, Michael Tachezy, Florian Gebauer, Tobias Lange, Kristoffer Riecken, Alexander Tonevitsky, Achim Aigner, Jakob Izbicki, Udo Schumacher, Daniel Wicklein
Summary: The knockdown of ITGAV in PDA cells significantly reduces primary tumor growth, peritoneal carcinomatosis, and spontaneous pulmonary metastasis. ITGAV activates latent TGF-beta and drives epithelial-mesenchymal transition. Combined depletion of ITGAV on tumor cells and E- and P-selectins in the tumor-host almost abolishes intraperitoneal spread.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Wen-Kai Shi, Qiao-Li Shang, Yong-Fu Zhao
Summary: This study investigates the role of SPC25 in promoting hepatocellular carcinoma (HCC) progression. It is found that SPC25 is highly expressed in HCC and associated with poor prognosis and metastasis. Silencing SPC25 inhibits invasion and migration of HCC cells in vitro and in vivo. The study also reveals that SPC25 affects genes associated with extracellular matrix-integrin interactions, and upregulation of ITGB4 partially reverses the decline in cell invasion and migration capacities caused by SPC25 silencing. Blocking both SPC25 and ITGB4 reduces phosphorylation of downstream elements in the integrin pathway. Overall, this research highlights the important role of SPC25 as both a prognostic indicator and a promoter of metastasis in HCC.
Article
Biotechnology & Applied Microbiology
Lijun Zhong, Lin Tang, Xiaoxia He
Summary: It has been discovered that ANGPTL3 plays an oncogenic role in several types of human malignancies. This study found that ANGPTL3 is highly expressed in cervical cancer cells and silencing ANGPTL3 can inhibit cell proliferation, migration, invasion, and angiogenesis. The inhibitory effect of ANGPTL3 can be offset by upregulating the expression of alpha v beta 3, which also promotes blood vessel formation and the secretion of VEGF and VEGFR2 in cervical cancer cells.
Article
Chemistry, Medicinal
Pichamon Kiatwuthinon, Thana Narkthong, Utapin Ngaokrajang, Supeecha Kumkate, Tavan Janvilisri
Summary: Baicalein was found to exhibit cytotoxicity and anti-proliferative activity on nasopharyngeal carcinoma cells, and significantly inhibited metastatic phenotypes. Transcriptome profiling revealed that baicalein inhibited metastatic phenotypes by modulating the expression of integrin beta 8.
Article
Oncology
Sachindra Sachindra, Teresa Hellberg, Samantha Exner, Sonal Prasad, Nicola Beindorff, Stephan Rogalla, Richard Kimura, Sanjiv Sam Gambhir, Bertram Wiedenmann, Carsten Groetzinger
Summary: The study evaluated a high-affinity molecular probe targeting PDAC tumors, showing promising tumor accumulation and moderate, rapidly declining kidney uptake for the tracer Lu-177-DOTA-integrin alpha v beta 6 knottin. These results support further preclinical treatment studies to establish therapeutic efficacy.
FRONTIERS IN ONCOLOGY
(2021)
Article
Immunology
Chun-Han Hou, Chih-Hsin Tang, Po-Chun Chen, Ju-Fang Liu
Summary: The study demonstrated that Thrombospondin-2 could promote the expression of IL-6 in osteoarthritis synovial fibroblasts in a dose-dependent manner, potentially involving signaling pathways such as integrin alpha(v)beta(3), PI3K, Akt, and NF-kappa B. Additionally, in a rat model of ACLT surgery, it was found that TSP2 neutralizing antibody had protective effects on cartilage destruction during OA progression.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Oncology
Parul Thakral, Subha Shankar Das, Shweta Dhiman, Divya Manda, C. B. Virupakshappa, Dharmender Malik, Ishita Sen
Summary: The purpose of this study was to validate the in-house kit-like synthesis of Ga-68-Trivehexin and evaluate its uptake in patients with integrin alpha v beta 6 expressing head and neck and pancreatic cancer. The results showed intense radiotracer uptake in tumors and no uptake in healthy tissues. PET/CT imaging at 60 minutes post injection was found to be the optimal time for imaging tumors with Ga-68-Trivehexin. This study demonstrates that Ga-68-Trivehexin is a promising agent for noninvasive molecular imaging of integrin alpha v beta 6 expressing tumors.
CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
(2023)
Review
Oncology
Yunyu Lian, Silue Zeng, Sai Wen, Xingyang Zhao, Chihua Fang, Ning Zeng
Summary: Integrin Alpha v Beta 6 is primarily expressed in solid epithelial tumors, such as cholangiocarcinoma, pancreatic cancer, and colorectal cancer. It is considered a potential and promising molecular marker for the early diagnosis and treatment of cancer. This review focuses on its role in cancer progression and its potential applications in molecular imaging and therapeutic targets.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2023)
Article
Biochemistry & Molecular Biology
Beatriz Cardenes, Irene Clares, Victor Toribio, Lucia Pascual, Soraya Lopez-Martin, Alvaro Torres-Gomez, Ricardo Sainz de la Cuesta, Esther M. Lafuente, Manuel Lopez-Cabrera, Maria Yanez-Mo, Carlos Cabanas
Summary: Research has shown that the interaction between integrin alpha 5 beta 1 on CRC cells and their ligand ADAM17 mediates the binding and uptake of CRC-derived exosomes, while the expression of CD9 on exosomes negatively regulates this process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Angelika Mojzisch, Maria A. Brehm
Summary: Von Willebrand factor (VWF) is synthesized exclusively in endothelial cells and megakaryocytes, and plays multiple roles in cellular processes such as angiogenesis, leukocyte adhesion, and tumor cell metastasis. Its dysregulation can lead to various pathophysiological consequences.
Review
Oncology
Xinru Zhou, Yin Jia, Chuanbin Mao, Shanrong Liu
Summary: Small extracellular vesicles (sEVs), such as exosomes, have emerged as crucial targets for liquid biopsy and promising drug delivery vehicles in tumor progression. They can serve as biomarkers for tumor diagnosis and as drug carriers for cancer treatment.
Article
Oncology
Ruochan Chen, Ju Zhu, Xiao Zhong, Jie Li, Rui Kang, Daolin Tang
Summary: The interplay between autophagy and apoptosis plays a crucial role in tumorigenesis and cancer therapy, with HMGB1 serving as a key regulator in these processes.
Article
Oncology
Zongfu Pan, Xixuan Lu, Tong Xu, Jinming Chen, Lisha Bao, Ying Li, Yingying Gong, Yulu Che, Xiaozhou Zou, Zhuo Tan, Ping Huang, Minghua Ge
Summary: This study uncovered the emerging role of HN1 in promoting dedifferentiation of anaplastic thyroid cancer (ATC) cells. HN1 negatively regulated the thyroid differentiation markers and had an inhibitory effect on the transcriptional activation of CTCF, thereby influencing the chromatin accessibility of thyroid differentiation genes.
Article
Oncology
Yi Qin, Shengjun Xiong, Jun Ren, Gautam Sethi
Summary: Autophagy plays an important regulatory role in glioblastoma, and its dysregulation can lead to drug resistance and radioresistance. It also affects stem cell characteristics, overall growth, and metastasis. Therefore, autophagy is a promising target for glioblastoma therapy.
Article
Oncology
Katsuya Nagaoka, Xuewei Bai, Dan Liu, Kevin Cao, Joud Mulla, Chengcheng Ji, Hongze Chen, Muhammad Azhar Nisar, Amalia Bay, William Mueller, Grace Hildebrand, Jin-Song Gao, Shaolei Lu, Hiroko Setoyama, Yasuhito Tanaka, Jack R. Wands, Chiung-Kuei Huang
Summary: This study found that serum 2-OG levels in cholangiocarcinoma patients are associated with the effectiveness of chemotherapy. Patients with progressive disease showed significantly higher levels of serum 2-OG compared to stable disease and partial response patients. The study also revealed that overexpression of ASPH mimics the effects of 2-OG, and knockdown of ASPH improves chemotherapy. Targeting ASPH enhances the effects of chemotherapy by modulating ATM and ATR, two key regulators of DDRs.
