期刊
CANCER LETTERS
卷 295, 期 1, 页码 17-26出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2010.02.009
关键词
Cancer; Immunotherapy; Dendritic cells
类别
资金
- Ministry of Science and Technology of China [2010CB945600, 2009ZX09503-24]
- Chinese Academy of Sciences [KSCX1-YW-22]
- National Natural Science Foundation of China [30873045, 30901317]
- Science and Technology Commission of Shanghai Municipality [074319102, 074119634, 08JC1413300, 09431901000, 07JC14070]
- Shanghai Municipal Education Commission [J50207]
We previously found that dendritic cell (DC) precursors could be recruited into the peripheral blood of B6 mice by administration of macrophage inflammatory protein (MIP)-1 alpha. These MIP-1 alpha-recruited DCs could induce anti-tumor protective immunity when pulsed with tumor cell lysate. In this study, MIP-1 alpha-recruited DCs could not effectively suppress preestablished tumor when pulsed with B16 tumor cell lysate. However, inoculation with these DCs expressing MACE-1 induced an anti-tumor immunity against preestablished solid and metastatic tumor from B16-MACE-1 cells. These MIP-1 alpha-recruited DCs expressed higher level of CCR7 and displayed a more significant chemotactic response toward secondary lymphoid tissue. Therefore, they are superior in the induction of cytotoxic T lymphocytes and the inhibition of tumor development and metastasis than bone marrow-derived DCs. This study established a novel approach to the treatment of preestablished solid and metastatic tumors using MIP-1 alpha-recruited DCs transduced with tumor antigen gene. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
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