期刊
CANCER LETTERS
卷 280, 期 2, 页码 154-159出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2008.11.019
关键词
HDAC; HDAC inhibitor; Inflammation-induced tumorigenesis
类别
资金
- Deutsche Forschungsgemeinschaft [SI 749/5-1]
Histone deacetylase (HDAC) inhibitors have been described in detail for their anti-proliferative potency. Recently, an anti-inflammatory property was characterized in vitro and in vivo. This dual efficacy of HDAC inhibitors is highly attractive, since chronic inflammations such as ulcerative colitis are associated with an increased risk of developing carcinomas. Additionally, in models of colitis and inflammation-induced tumorigenesis inflammation as well as tumor development was significantly inhibited by HDAC inhibitor treatment. The mechanisms involved reach beyond the simple regulation of histone acetylation and deacetylation. The currently known key target structures and mechanisms mediating this dual effect will be discussed in this review. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据