Article
Agriculture, Multidisciplinary
Guili Zhao, Wenjuan Zhang, Xiaodong Fu, Xin Xie, Song Bai, Xiangyang Li
Summary: The viral protein genome-linked protein of telosma mosaic virus plays an important role in viral reproduction. This study explored the expression conditions of the protein and synthesized a series of novel compounds. The compounds exhibited excellent binding affinity to the viral protein and inhibited its expression.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Gastroenterology & Hepatology
Ryan A. Hlady, Xia Zhao, Louis Y. El Khoury, Aesis Luna, Kien Pham, Qunfeng Wu, Jeong-Heon Lee, Nikolaos T. Pyrsopoulos, Chen Liu, Keith D. Robertson
Summary: Chronic HCV infection significantly impacts the epigenome, especially enhancers; HCV shares epigenetic targets with interferon-alpha; the majority of epigenetic changes induced by HCV persist as scars on the epigenome after viral cure.
Review
Immunology
Jiajia Yang, Dawei Wang, Yuancheng Li, Hongmei Wang, Qiang Hu, Ying Wang
Summary: Viral hepatitis is a global public health issue, causing significant morbidity and mortality. The burden of viral hepatitis is mainly caused by five unrelated hepatotropic viruses: HAV, HBV, HCV, HDV, and HEV. Metabolomics, an emerging technology, can provide information about metabolic levels and changes in metabolic pathways. Changes in glucose, lipid, and amino acid levels are associated with the pathogenesis and medication mechanism of viral hepatitis. Differential metabolites can be used as biomarkers for diagnosis, prognosis, and therapeutic responses. This review provides a comprehensive overview of metabolomics in viral hepatitis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Virology
Tristan R. Grams, Terri G. Edwards, David C. Bloom
Summary: Herpes simplex virus 1 (HSV-1) utilizes a long noncoding RNA called the latency-associated transcript (LAT) to silence the virus in neurons. This study demonstrates that LAT binds both the cellular transmembrane protein 43 (TMEM43) and HSV-1 genomes in human neurons, resulting in the localization of the viral genomes to the nuclear periphery and repression of viral transcription. Additionally, TMEM43 appears to play a similar role in regulating cellular genes.
JOURNAL OF VIROLOGY
(2023)
Review
Virology
Yanting Du, Chen Wang, Ying Zhang
Summary: Viral coinfection is widespread in nature and can lead to altered viral pathogenicity, disrupted host defense, and mixed clinical symptoms. We analyzed virus-virus interactions from both the perspectives of viruses and hosts and elucidated possible mechanisms.
Review
Biochemistry & Molecular Biology
Cristina Bayo, Gerhard Jung, Marta Espanol-Rego, Francesc Balaguer, Daniel Benitez-Ribas
Summary: Cancer vaccines aim to modulate the immune system to induce protective immune responses against cancer-related antigens. Administering cancer-preventive vaccination at early stages is seen as a potential way to increase clinical efficacy, as research begins to focus on these approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Michal Largman-Chalamish, Asaf Wasserman, Adi Silberman, Tal Levinson, Omri Ritter, Shlomo Berliner, David Zeltser, Itzhak Shapira, Ori Rogowski, Shani Shenhar-Tsarfaty
Summary: This study utilized estimated C-reactive protein velocity (eCRPv) to differentiate between acute viral and bacterial infections. By dividing the admission CRP level by time from symptom onset, eCRPv can provide a rapid and accurate differentiation, especially for patients with high CRP values.
Review
Immunology
Iole Macchia, Valentina La Sorsa, Francesca Urbani, Sonia Moretti, Caterina Antonucci, Claudia Afferni, Giovanna Schiavoni
Summary: Eosinophils are important in allergic asthma and parasitic infections, but they also participate in the immune response against respiratory viruses. In the context of COVID-19, eosinophils can serve as potential biomarkers for diagnosis, prognosis, and severity prediction. This review provides an overview of the role of eosinophils in various respiratory viral infections and discusses their utility as prognostic/predictive immune biomarkers in emerging respiratory viral diseases, particularly COVID-19.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yaling Zhao, Xue Cao, Weihua Zhong, Shunkang Zhou, Zhanbiao Li, Hong An, Xiahua Liu, Ruifeng Wu, Surakshya Bohora, Yan Wu, Zhenyi Liang, Jiahao Chen, Xin Yang, Guohui Zhou, Tong Zhang
Summary: This study reveals the molecular mechanism of transmission of the Southern rice black-streaked dwarf virus (SRBSDV), finding that the SRBSDV-encoded P6 protein regulates rice ethylene signaling to coordinate viral infection and transmission. In early infection, P6 interacts with OsRTH2 to activate ethylene signaling and enhance virus proliferation, repelling the insect vector. In late infection, P6 enters the nucleus and interacts with OsEIL2 to suppress ethylene signaling, attracting the insect vector for viral transmission.
Review
Clinical Neurology
Huong X. T. Nguyen, Kate Bradley, Bridgette J. McNamara, Rosie Watson, Roslyn Malay, Dina LoGiudice
Summary: Dementia is a pressing health priority for Indigenous peoples globally. This study aims to investigate the risk, protective, genetic, neuroradiological, and biological factors related to dementia and cognitive impairment in Indigenous peoples. The findings suggest that modifiable risk factors for dementia include childhood adversity, hearing loss, low education attainment, unskilled work history, stroke, head injury, epilepsy, diabetes, hypertension, hyperlipidemia, depression, low BMI, poor mobility, and continence issues. Non-modifiable risk factors include increasing age, sex, and genetic polymorphisms. Education, ex-smoking, physical and social activity, and engagement with cultural or religious practices are highlighted as potential protective factors. There is a lack of research on dementia biomarkers involving Indigenous peoples.
ALZHEIMERS & DEMENTIA
(2023)
Review
Immunology
Soo-Jeung Park, Da-eun Nam, Hae Chang Seong, Young S. Hahn
Summary: Myeloid-derived suppressor cells (MDSCs) play an important role in viral infections by suppressing host immune responses and balancing viral infection and tissue damage. Viruses can evade immune recognition by inducing the differentiation and expansion of MDSCs. This article provides an overview of the immunomodulation and genetic regulation of MDSCs during viral infections, with a specific focus on the role of MDSCs in SARS-CoV-2 infection and COVID-19, and discusses potential therapeutics targeting MDSCs.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Chemistry, Analytical
Lais Canniatti Brazaca, Pamyla Layene dos Santos, Paulo Roberto de Oliveira, Diego Pessoa Rocha, Jessica Santos Stefano, Cristiane Kalinke, Rodrigo Alejandro Abarza Munoz, Juliano Alves Bonacin, Bruno Campos Janegitz, Emanuel Carrilho
Summary: This critical review article discusses the advancements in electrochemical biosensors for diagnosing viral infections, focusing on genosensors, aptasensors, and immunosensors. The article also addresses the advantages of biosensors in viral disease diagnosis and potential future trends in the field, such as lab-on-a-chip and flexible sensors.
ANALYTICA CHIMICA ACTA
(2021)
Review
Virology
Piotr Rzymski, Agnieszka Szuster-Ciesielska, Tomasz Dzieciatkowski, Willis Gwenzi, Andrzej Fal
Summary: mRNA vaccines are life-saving interventions and have shown promise in providing protection against various viruses. There are ongoing technological challenges in developing the mRNA platform, as well as potential for manufacturing in low-income countries. The continued research and interest in mRNA technology may overcome existing challenges and expand the portfolio of authorized vaccines, opening up new pathways against infections with no current immunization methods.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Veerasamy Yengopal, Temitope Ayodeji Esan, Zorayda Joosab
Summary: The study found that there was a weak association between caries among HIV+ children and CD4 counts, viral load, and WHO clinical stage of the disease. Correlation analyses showed significant associations between VL and CD4 count, as well as VL and WHO stage. However, there was no substantial evidence of a significant association between the presence of caries and these factors in HIV+ children.
INTERNATIONAL JOURNAL OF PAEDIATRIC DENTISTRY
(2021)
Review
Biochemistry & Molecular Biology
Meng Yang, Yule Liu
Summary: This review focuses on the roles of autophagy in plant virus infection and offers a glimpse of recent advances in how plant viruses manipulate host autophagy pathways.
Review
Oncology
Zdenko Herceg, Akram Ghantous, Christopher P. Wild, Athena Sklias, Lavinia Casati, Susan J. Duthie, Rebecca Fry, Jean-Pierre Issa, Richard Kellermayer, Igor Koturbash, Yukata Kondo, Johanna Lepeule, Sheila C. S. Lima, Carmen J. Marsit, Vardhman Rakyan, Richard Saffery, Jack A. Taylor, Andrew E. Teschendorff, Toshikazu Ushijima, Paolo Vineis, Cheryl Lyn Walker, Robert A. Waterland, Joe Wiemels, Srikant Ambatipudi, Davide Degli Esposti, Hector Hernandez-Vargas
INTERNATIONAL JOURNAL OF CANCER
(2018)
Article
Public, Environmental & Occupational Health
Michelle C. Turner, Paolo Vineis, Eduardo Seleiro, Michaela Dijmarescu, David Balshaw, Roberto Bertollini, Marc Chadeau-Hyam, Timothy Gant, John Gulliver, Ayoung Jeong, Soterios Kyrtopoulos, Marco Martuzzi, Gary W. Miller, Timothy Nawrot, Mark Nieuwenhuijsen, David H. Phillips, Nicole Probst-Hensch, Jonathan Samet, Roel Vermeulen, Jelle Vlaanderen, Martine Vrijheid, Christopher Wild, Manolis Kogevinas
Article
Oncology
Farida Selmouni, Ahmed Zidouh, Latifa Belakhel, Catherine Sauvaget, Maria Bennani, Youssef Chami Khazraji, Abdellatif Benider, Christopher P. Wild, Rachid Bekkali, Ibtihal Fadhil, Rengaswamy Sankaranarayanan
Article
Oncology
Salvatore Vaccarella, Joannie Lortet-Tieulent, Rodolfo Saracci, Miranda M. Fidler, David I. Conway, Nadia Vilahur, Diana Sarfati, Ahmedin Jemal, Johan P. Mackenbach, Michael G. Marmot, Kurt Straif, Christopher P. Wild
CA-A CANCER JOURNAL FOR CLINICIANS
(2018)
Article
Public, Environmental & Occupational Health
Sinead Watson, Sophie E. Moore, Momodou K. Darboe, Gaoyun Chen, Yu-Kang Tu, Yi-Ting Huang, Kamilla G. Eriksen, Robin M. Bernstein, Andrew M. Prentice, Christopher P. Wild, Ya Xu, Michael N. Routledge, Yun Yun Gong
Article
Nutrition & Dietetics
Veronique Chajes, Lorna J. Gibson, Carine Biessy, Nadia Slimani, Gershim Asiki, Laure Dossus, Christopher P. Wild, Robert Newton
BRITISH JOURNAL OF NUTRITION
(2019)
Review
Oncology
Joachim Schuz, Carolina Espina, Christopher P. Wild
MOLECULAR ONCOLOGY
(2019)
Review
Oncology
Christopher P. Wild, Carolina Espina, Linda Bauld, Bernardo Bonanni, Hermann Brenner, Karen Brown, Joakim Dillner, David Forman, Ellen Kampman, Mef Nilbert, Karen Steindorf, Hans Storm, Paolo Vineis, Michael Baumann, Joachim Schuez
MOLECULAR ONCOLOGY
(2019)
Editorial Material
Oncology
Ulrik Ringborg, Julio E. Celis, Michael Baumann, Alexander Eggermont, Christopher P. Wild, Anton Berns
MOLECULAR ONCOLOGY
(2019)
Article
Cell Biology
Maimuna Mendy, Elodie Caboux, Christopher P. Wild, Rolando Herrero, Rosita Accardi-Gheit, Gary Clifford, Elisabeth Francon, Ausrele Kesminiene, James Mckay, Sabina Rinaldi, Augustin Scalbert, Ghislaine Scello, Eduardo Seleiro, Jiri Zavadil
BIOPRESERVATION AND BIOBANKING
(2019)
Article
Oncology
Jonathan M. Samet, Weihsueh A. Chiu, Vincent Cogliano, Jennifer Jinot, David Kriebel, Ruth M. Lunn, Frederick A. Beland, Lisa Bero, Patience Browne, Lin Fritschi, Jun Kanno, Dirk W. Lachenmeier, Qing Lan, Gerard Lasfargues, Frank Le Curieux, Susan Peters, Pamela Shubat, Hideko Sone, Mary C. White, Jon Williamson, Marianna Yakubovskaya, Jack Siemiatycki, Paul A. White, Kathryn Z. Guyton, Mary K. Schubauer-Berigan, Amy L. Hall, Yann Grosse, Veronique Bouvard, Lamia Benbrahim-Tallaa, Fatiha El Ghissassi, Beatrice Lauby-Secretan, Bruce Armstrong, Rodolfo Saracci, Jiri Zavadil, Kurt Straif, Christopher P. Wild
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2020)
Meeting Abstract
Oncology
Christopher P. Wild
CANCER PREVENTION RESEARCH
(2020)
Meeting Abstract
Pathology
B. Abedi-Ardekani, D. Nasrollahzadeh, R. Njie, S. O. Bittaye, C. Carreira, M. Salieu Jallow, M. Almonte, C. P. Wild
Article
Surgery
Christopher Battista, Christopher Wild, Sarah Kreul, Michael Albert
INTERNATIONAL JOURNAL OF SPINE SURGERY
(2018)
Review
Health Policy & Services
David Forman, Linda Bauld, Bernardo Bonanni, Hermann Brenner, Karen Brown, Joakim Dillner, Ellen Kampman, Marta Manczuk, Elio Riboli, Karen Steindorf, Hans Storm, Carolina Espina, Christopher P. Wild
JOURNAL OF CANCER POLICY
(2018)
Review
Oncology
Xinru Zhou, Yin Jia, Chuanbin Mao, Shanrong Liu
Summary: Small extracellular vesicles (sEVs), such as exosomes, have emerged as crucial targets for liquid biopsy and promising drug delivery vehicles in tumor progression. They can serve as biomarkers for tumor diagnosis and as drug carriers for cancer treatment.
Article
Oncology
Ruochan Chen, Ju Zhu, Xiao Zhong, Jie Li, Rui Kang, Daolin Tang
Summary: The interplay between autophagy and apoptosis plays a crucial role in tumorigenesis and cancer therapy, with HMGB1 serving as a key regulator in these processes.
Article
Oncology
Zongfu Pan, Xixuan Lu, Tong Xu, Jinming Chen, Lisha Bao, Ying Li, Yingying Gong, Yulu Che, Xiaozhou Zou, Zhuo Tan, Ping Huang, Minghua Ge
Summary: This study uncovered the emerging role of HN1 in promoting dedifferentiation of anaplastic thyroid cancer (ATC) cells. HN1 negatively regulated the thyroid differentiation markers and had an inhibitory effect on the transcriptional activation of CTCF, thereby influencing the chromatin accessibility of thyroid differentiation genes.
Article
Oncology
Yi Qin, Shengjun Xiong, Jun Ren, Gautam Sethi
Summary: Autophagy plays an important regulatory role in glioblastoma, and its dysregulation can lead to drug resistance and radioresistance. It also affects stem cell characteristics, overall growth, and metastasis. Therefore, autophagy is a promising target for glioblastoma therapy.
Article
Oncology
Katsuya Nagaoka, Xuewei Bai, Dan Liu, Kevin Cao, Joud Mulla, Chengcheng Ji, Hongze Chen, Muhammad Azhar Nisar, Amalia Bay, William Mueller, Grace Hildebrand, Jin-Song Gao, Shaolei Lu, Hiroko Setoyama, Yasuhito Tanaka, Jack R. Wands, Chiung-Kuei Huang
Summary: This study found that serum 2-OG levels in cholangiocarcinoma patients are associated with the effectiveness of chemotherapy. Patients with progressive disease showed significantly higher levels of serum 2-OG compared to stable disease and partial response patients. The study also revealed that overexpression of ASPH mimics the effects of 2-OG, and knockdown of ASPH improves chemotherapy. Targeting ASPH enhances the effects of chemotherapy by modulating ATM and ATR, two key regulators of DDRs.
