期刊
CANCER LETTERS
卷 285, 期 2, 页码 190-199出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2009.05.014
关键词
Alpha-fetoprotein; Hepatoma; All trans retinoic acid; Nuclear receptor; Apoptosis
类别
资金
- National Natural Science Foundation of China [30621002, 30671856, 30772536, 30660071, 30760090]
- Foundation of National Education Ministry for graduate [20070001735]
The role of AFP in the retinoic acid-RAR signaling pathway was investigated in human hepatoma Bel 7402 cells. The results showed that AFP and RAR-beta were co-localized and interacted in cytoplasm. AFP may inhibit translocation of RAR-beta into the nucleus via competitive binding to RAR-beta with ATRA, which was reversed by AFP-siRNA transfection. Our data suggest that the ATRA resistance of Bel 7402 cells is at least in part attributable to their high level of cytoplasmic AFP. Thus, by counteracting the effect of AFP, it may be possible to increase the sensitivity of tumor cells to ATRA. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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