期刊
CANCER LETTERS
卷 284, 期 1, 页码 71-79出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2009.04.020
关键词
Glioma-initiating cells; Interferon; Oligodendrogenesis; Differentiation
类别
The response of cancer patients to interferon (IFN) treatment is long-lasting, indicating that IFN may act on small cancer stem cell populations. Glioma-initiating cells (GICs) can self-renew and induce the formation of heterogeneously differentiated tumor cells and are resistant to chemotherapeutic agents like temozolomide. In this study, we showed that via STAT3 signaling, IFN-beta suppressed the proliferation, self-renewal, and tumorigenesis of GICs, induced their terminal differentiation to mature oligodendroglia-like cells, and exhibited synergistic cytotoxicity with temozolomide. Therefore, IFN may be a potential therapeutic agent for inducing the terminal differentiation of GICs. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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