期刊
CANCER LETTERS
卷 277, 期 1, 页码 22-28出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2008.11.022
关键词
Bcl-w; Migration; Cell signaling; Gastric carcinoma
类别
资金
- Korea Science and Engineering Foundation (KOSEF)
- Ministry of Science and Technology (MOST) of the Korean government
- Ministry of Education, Science and Technology in Korea [FG08-21-12]
- Korean Government (MOEHRD) [KRF-2006-311-C00563]
We have previously reported that Bcl-w enhances the invasiveness of gastric cancer cells by inducing MMP-2 expression via phosphoinositide 3-kinase (PI3K), Akt and Sp1. This study demonstrates that Bcl-w additionally induces uPA expression and FAK activation. Analyses of the hierarchical relationship and functions of these components showed that the PI3K-Akt-Sp1 pathway also mediates the induction of uPA, and that both uPA and MMP-2 contribute to Bcl-w-induced invasion via the stimulation of the FAK-dependent migratory pathway. These findings significantly advance our understandings of the Bcl-w-induced signaling processes that results in the migration and invasion of cancer cells. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
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