期刊
CANCER LETTERS
卷 276, 期 1, 页码 32-37出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2008.10.024
关键词
SUDS3; BRMS1; Metastasis suppression; Motility
类别
资金
- National Institute of Health [CA87728, F32CA113037]
- National Foundation for Cancer Research Center for Metastasis Research
BRMS1 and SUDS3 are related members of SIN3-HDAC chromatin remodeling complexes. We hypothesized that they might have overlapping functions and that SUDS3 over-expression could compensate for BRMS1 deficiency. SUDS3 expression was ubiquitous in seven breast cell lines, regardless of metastatic potential. SUDS3 over-expression in BRMS1-non-expressing metastatic cells did not suppress metastasis, motility, osteopontin secretion, or EGF receptor expression, phenotypes associated with BRMS1-mediated metastasis suppression. This study demonstrates functional differences for BRMS1 family members and highlights how the composition of SIN3-HDAC (BRMS1/SUDS3) complexes uniquely affects protein expression and biological behaviors. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据