期刊
CANCER LETTERS
卷 269, 期 1, 页码 46-56出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2008.04.016
关键词
breast cancer metastasis suppressor 1; non-small cell lung cancer; metastasis; chemokine (C-X-C mottif) receptor 4
类别
资金
- National Natural Science Foundation of China [30771219]
- Science Research Foundation of Chinese Ministry of Health [WKJ2007-3-001]
This report shows that over-expression of BRMS1 reduces SDF-induced chemotaxis and suppresses nuclear factor-kappa B (NF-kappa B) activity in NSCLC cell line. Inhibition of NF-kappa B activity impairs SDF-1 alpha-dependent migration and NF-kappa B can directly bind to the chemokine (C-X-C motto receptor 4 (CXCR4) promoter in vivo. However, knockdown of BRMS1 promotes NSCLC cell migration and CXCR4 expression. Furthermore, BRMS1 and CXCR4 expression levels are inversely correlated in the NSCLC cases. The level of BRMS1 mRNA is found to be markedly lower in the distant metastasis group than in the non-distant metastasis group (P = 0.003). However, CXCR4 mRNA was higher in the distant metastasis group than in the non-distant metastasis group (P = 0.032). These results indicate that BRMS1 regulates metastatic potential at least in part through the down-regulation of CXCR4, to be indirectly regulated by BRMS1 through nuclear factor-kappa B activation. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
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