期刊
CANCER LETTERS
卷 263, 期 2, 页码 312-320出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2008.01.008
关键词
mRNA; cyclin D1; TS; plasma; prognostic; breast cancer
类别
We studied by real-time PCR cyclin D1 and thymidylate synthase (TS) mRNA in plasma as possible markers of clinical outcome in breast cancer. We observed poor outcome in patients with presence of cyclin D1 mRNA in good-prognosis groups, such as negative vascular invasion. Presence of both markers was associated with non-response to treatment after relapse. In patients treated with tamoxifen, a trend to significant relation between poor outcome and cyclin D1 mRNA was found. Cyclin D1 mRNA in plasma could identify patients with poor overall survival in good-prognosis groups and patients non-responsive to tamoxifen. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
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