期刊
CANCER LETTERS
卷 271, 期 1, 页码 64-80出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2008.05.047
关键词
sPDZD2; p53; Prostate; Breast; Liver
类别
资金
- University of Hong Kong
- [HKU7474/04M]
- [200507176053]
- [200611159071]
- [HKU7580/05M]
Tumor suppressive actions of the autocrine human secreted PDZ domain-containing protein 2 (sPDZD2) have been reported, but the mechanisms remain enigmatic. Here, we showed that sPDZD2 induced senescence of prostate cancer DU145 cells, quiescence of breast cancer MCF-7 and liver cancer Hep-G2 cells, via transcriptional activation of mutant or wild-type p53. Furthermore, sPDZD2 sensitized mutant p53-positive DU145 cells and wild-type p53-positive MCF-7 cells to apoptosis induction through genotoxic stress imposed by sub-lethal concentration of hydrogen peroxide. Together our findings suggest a potential autocrine pathway of p53 activation by transcriptional regulation, and a new approach to reactivate p53 for cancer therapy. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
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