期刊
CANCER LETTERS
卷 270, 期 2, 页码 242-249出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2008.05.014
关键词
Chenodeoxycholic acid derivative; Hepatoma cell line; Apoptosis; Mitochondria; Cytochrome c
类别
资金
- Shandong Science and Technology Committee of China [2005GG3202192]
We investigated whether HS-1200 has anti-proliferation effects on human hepatoma cells in vitro. Here, chromatin condensation, DNA ladder formation and proteolytic cleavage of poly (ADP-ribose) polymerase (PARP) were observed after treatment of HS-1200, indicating the occurrence of apoptotic cell death, which was associated with up-regulation of Bax, cleaved-caspase-3 and cleaved-caspase-9. Inhibition of caspase-9 rescued HS-1200-induced apoptosis. Furthermore, cells treated with HS-1200 showed a reduction in mitochondrial membrane potential (Delta psi(m).) and caused cytochrome c release into the cytosol. The results indicated that synthetic chenodeoxycholic acid HS-1200 could induce cell apoptosis in BEL7402 human hepatoma cell line, via a Bax/cytochrome c/caspase-9 independent pathway. This study suggested that HS-1200 is potentially useful as an apoptosis inducer for the treatment of hepatocellular carcinoma. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
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