Article
Pharmacology & Pharmacy
Xuelian Cheng, Jingjing Li, Limei Feng, Songwei Feng, Xiao Wu, Yongming Li
Summary: The study identifies HRGs as potential biomarkers for patients with refractory TACE and provides a novel immunological perspective for developing personalized therapies.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Immunology
Sihang Yu, Lei Zhou, Jiaying Fu, Long Xu, Buhan Liu, Yuanxin Zhao, Jian Wang, Xiaoyu Yan, Jing Su
Summary: There is increasing evidence showing the crucial role of the immune microenvironment, particularly the polarization state and function of macrophages, in the development of hepatocellular carcinoma. Tumor-derived exosomes in hepatocellular carcinoma act as information carriers and regulate the physiological state of cells in the microenvironment, thus controlling cancer progression. This review focuses on the role of exosome content in disease outcomes at different stages of hepatitis B virus/hepatitis C virus-induced hepatocellular carcinoma, and explores the mechanism by which macrophages contribute to hepatocellular carcinoma formation and the regulation of macrophage functions by the heterogeneity of exosome loading. The application prospects of exosome-based targeted drug delivery in immunotherapy research on hepatocellular carcinoma are also summarized.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Yun Liu, Hao Zhuang, Fang Cao, Jie Li, Yan Guo, Jun Zhang, Qiang Zhao, Yuanyuan Liu
Summary: High expression of Shc3 was observed in patients with chemoresistant and recurrent HCCs. Shc3 overexpression increased MDR1/P-glycoprotein expression and reduced HCC cell sensitivity to doxorubicin and sorafenib. This study suggests a potential strategy to target the Shc3 pathway in conjunction with systemic chemotherapy for improved clinical treatment of HCC.
CELL DEATH & DISEASE
(2021)
Review
Oncology
GuoYun Wang, GaiXiang Luo, MeiJing Zhao, HuiLai Miao
Summary: This article discusses the research progress on exosomes in the development of hepatocellular carcinoma, tumor microenvironment, treatment resistance, and immunosuppression. Understanding the pathogenesis and identifying early diagnostic markers are crucial for diagnosing and treating HCC.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Shuang Li, Limin Chen
Summary: Exosomes are extracellular vesicles that play important roles in cell-to-cell communication and can be stably present in various body fluids. They have a unique double-layer saclike structure and reflect the characteristics of their host cells. Exosomes derived from hepatocellular carcinoma cells show heterogeneity in their cargo. Additionally, exosomes are capable of efficiently delivering cargoes to target cells, which significantly impact HCC progression, including tumor occurrence, development, metastasis, immune regulation, and drug resistance. Previous studies have demonstrated wide applications of exosomes in the diagnosis and treatment of HCC. This review discusses recent findings on the significant roles of exosomes in HCC, focusing on their effects and underlying mechanisms in regulating HCC progression and their potential clinical value as biomarkers and therapeutic targets.
FRONTIERS IN ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
Songpeng Yang, Shu Yang, Hongying Zhang, Hui Hua, Qingbin Kong, Jiao Wang, Yangfu Jiang
Summary: Berbamine and ouabain synergize with sorafenib to inhibit hepatocellular carcinoma cells growth by activating p38MAPK and EGFR-ERK pathways. The combination of sorafenib with berbamine or ouabain synergistically inhibits both sorafenib-naive and sorafenib-resistant hepatocellular carcinoma cells growth, induces cell death, and significantly inhibits hepatocellular carcinoma xenografts growth in vivo. Targeting Na+/K+-ATPase represents a novel strategy to potentiate the anti-hepatocellular carcinoma effects of sorafenib.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Review
Cell Biology
Fan Pan, Xin-Rong Lin, Li-Ping Hao, Xiao-Yuan Chu, Hai-Jun Wan, Rui Wang
Summary: Hepatocellular carcinoma (HCC) is the 6th most prevalent cancer globally, and m6A modification may play a role in its pathogenesis. METTL3, a key methyltransferase, is involved in the carcinogenesis and progression of HCC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Jia Zheng, Zhihong Yang, Yanlei Li, Li Yang, Ruili Yao
Summary: AKR1C3, highly expressed in sorafenib-resistant patients, promotes HCC cell proliferation and acute sorafenib resistance through AKT phosphorylation. Targeting AKR1C3 may be a promising therapeutic strategy to overcome sorafenib resistance in HCC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Shuhua Wei, Fenghua Wei, Mengyuan Li, Yuhan Yang, Jingwen Zhang, Chunxiao Li, Junjie Wang
Summary: Sorafenib, a multi-kinase inhibitor, has been approved for cancer treatment, especially hepatocellular carcinoma (HCC). However, many cancer patients acquire drug resistance to sorafenib in subsequent treatment, and the immunological mechanisms behind this resistance are still unclear. This review focuses on the immunoregulatory effects of sorafenib on the tumor microenvironment, the potential immunological mechanisms of therapeutic resistance, and the combination of sorafenib with immunotherapy to improve efficacy.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Cui Tang, Shixiong Qiu, Wenying Mou, Jinming Xu, Peijun Wang
Summary: The transcription factor HOXB13 is involved in the occurrence, progression, and drug resistance of various cancers. This study revealed that HOXB13 is up-regulated in hepatocellular carcinoma (HCC) tissues and promotes the multiplication, metastasis, and drug resistance of HCC cells. The mechanism involves the activation of PIMREG transcription by HOXB13, which in turn regulates the expression of cell cycle and DNA repair-related factors. These findings provide insights into the role of HOXB13 in HCC and its potential as a target for HCC treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Cell Biology
Siqi Zhao, Wubin Zheng, Chao Yu, Gaoxin Xu, Xinyi Zhang, Chao Pan, Yongheng Feng, Kunxing Yang, Jin Zhou, Yong Ma
Summary: Cell death is crucial in the development of multicellular organisms and degenerative diseases. Ferroptosis, a distinct form of cell death mediated by iron-dependent lipid peroxidation, has been found to be involved in various diseases, including HCC. Recent advances have shed light on the specific mechanisms of ferroptosis in HCC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Engineering, Environmental
Huimin Lin, Qing Xu, Fang Zhang, Hualan Wu, Ben Hu, Guimei Chen, Xiaohua Ban, Xiaohui Duan, Meng Yu
Summary: Induction of tumor stemness is a key factor in acquired drug-resistance during traditional treatments. Sorafenib, an anti-angiogenic drug, has been the first-line treatment for hepatocellular carcinoma (HCC), but drug resistance remains a challenge. Upregulation of hypoxia-inducible factors (HIFs) by sorafenib contributes to acquired stemness-related drug resistance in HCC. To overcome this, piceatannol (PCT) was used to form a carrier-free nanomedicine (FPSN) with sorafenib and Fe3+ via chelation bonding, which showed potential in overcoming drug resistance in HCC by targeting HIFs and neovascularization blockade.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Oncology
Veronica Zelli, Chiara Compagnoni, Roberta Capelli, Alessandra Corrente, Mauro Di Vito Nolfi, Francesca Zazzeroni, Edoardo Alesse, Alessandra Tessitore
Summary: Extracellular vesicles (EVs), including exosomes, play crucial roles in hepatocellular carcinoma (HCC) therapy. Exosomal miRNAs carried by EVs are involved in regulating tumor behavior, reshaping tumor microenvironment, and contributing to drug resistance mechanisms.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Hsin-An Chen, Chi-Cheng Li, Yu-Jung Lin, Tso-Fu Wang, Ming-Cheng Chen, Yen-Hao Su, Yu-Lan Yeh, V. Vijaya Padma, Po-Hsiang Liao, Chih-Yang Huang
Summary: This study investigated the mechanism of resistance of hepatocellular carcinoma cells to histone deacetylase inhibitors, and found that downregulation of miR-107 leads to resistance in hepatocellular carcinoma cells.
Article
Pharmacology & Pharmacy
Elisa Herraez, Ruba Al-Abdulla, Meraris Soto, Oscar Briz, Dominik Bettinger, Heike Bantel, Sofia del Carmen, Maria A. Serrano, Andreas Geier, Jose J. G. Marin, Rocio I. R. Macias
Summary: Impaired function of organic cation transporter 1 (OCT1) in hepatocellular carcinoma (HCC) has been associated with unsatisfactory response to sorafenib. However, some patients lacking OCT1 at the plasma membrane (PM) of HCC cells still respond to sorafenib, suggesting that another transporter may contribute to take up this drug. The aim of this study was to investigate whether OCT3 could contribute to the uptake of sorafenib and other tyrosine kinase inhibitors (TKIs) and whether OCT3 determination can predict HCC response to sorafenib. Functional in vitro studies revealed that OCT3 is also able to mediate sorafenib uptake. Other TKIs, such as regorafenib, lenvatinib, and cabozantinib can also interact with this transporter. In HCC samples, OCT3 was expressed at the PM of cancer cells, and its presence, detected in 26% of tumors, was associated with better outcomes in patients treated with sorafenib. Analysis by immunohistochemistry of OCT3 in the PM of tumor cells may help to predict the response of HCC patients to sorafenib and potentially to other TKIs.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Engineering, Electrical & Electronic
Zhenxiao Fu, Amit Kumar Shukla, Zhiqiang Mu, Kai Lu, Yemin Dong, Ziyan Luo, Xuepeng Qiu, Zhifeng Zhu, Yumeng Yang
Summary: This work thoroughly examines the effect of out-of-plane polarized spin current through macro-spin simulations. The spin polarization is found to have a significant impact on the performance of spintronic memory and oscillator devices, emphasizing the importance of deliberate control.
IEEE TRANSACTIONS ON ELECTRON DEVICES
(2022)
Article
Materials Science, Multidisciplinary
Peng Wu, Jun Yan, Pengli Liang, Zhifeng Zhu, Tao Wu
Summary: This study investigated the longitudinal resistivity, magnetization, and ferromagnetic resonance (FMR) properties of Mn3SnC material. Abnormal thermal hysteresis loop and angular-dependent longitudinal resistivity were observed for the first time under an in-plane magnetic field. The angular-dependent resistivity measurement revealed a correlation between the transport properties of Mn3SnC and the in-plane magnetic field orientation.
PHYSICA STATUS SOLIDI-RAPID RESEARCH LETTERS
(2022)
Article
Physics, Fluids & Plasmas
Zhifeng Zhu, Bo Li, Qiang Gao, Jiajian Zhu, Zhongshan Li
Summary: In this study, a femtosecond laser filament was used to trigger and guide a high-voltage DC pulse discharge, achieving spatiotemporal control of the discharge plasma. By optimizing parameters, sub-nanosecond jitter of the discharge could be achieved. This technique shows great potential in gas flow field composition measurement and studying the spatiotemporal evolution of discharge plasma.
PLASMA SCIENCE & TECHNOLOGY
(2022)
Article
Cell Biology
Haixu Xu, Jie Zhao, Jinping Li, Zhifeng Zhu, Zhaohai Cui, Ran Liu, Rong Lu, Zhi Yao, Qiong Xu
Summary: This study identifies a novel mechanism in which CAF-derived chemokine CCL5 enhances the metastasis and invasion of HCC through the HIF1 alpha/ZEB1 axis. This finding may have implications for the prognosis of HCC and provides a new therapeutic target for HCC.
CELL DEATH & DISEASE
(2022)
Article
Engineering, Electrical & Electronic
K. Yadagiri, Jingwei Long, Yuxi Wang, Zhifeng Zhu, T. Wu
Summary: This article presents low damping FeGaB and Al2O3/FeGaB thin films. FeGaB exhibits lower damping factor than Al2O3/FeGaB. The coercive field and magnetic anisotropy of Al2O3/FeGaB thin films are enhanced due to static magnetization. The magnetic domain wall velocity is larger in FeGaB thin film due to its low anisotropy and the impact of spin-orbit coupling. These findings suggest the potential applications of these films in microwave and spintronic devices.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
(2022)
Article
Optics
Zhifeng Zhu, Qiang Gao, Bo Li, Zhanyu Feng, Ercong Gao, Ming Li, Zhongshan Li
Summary: In this paper, a new method called femtosecond laser filament-triggered discharge plasma spectroscopy is proposed for one-dimensional equivalence ratio measurements. The experimental results demonstrate the capability of this method to accurately measure the equivalence ratio in combustion flow fields, with some dependence on the temperature of the methane-air mixture.
OPTICS AND LASERS IN ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Jingwei Long, Qi Hu, Zhengping Yuan, Yunsen Zhang, Yue Xin, Jie Ren, Bowen Dong, Gengfei Li, Yumeng Yang, Huihui Li, Zhifeng Zhu
Summary: The writing performance of easy-cone magnetic tunnel junction (MTJ) and perpendicularly magnetized MTJ (pMTJ) was investigated under different temperatures using the macrospin model. The easy-cone MTJ exhibited a more stable writing performance and wider operating temperature range compared to the pMTJ. Additionally, the two types of MTJs showed opposite temperature dependence in current overdrive and write error rate, indicating that the easy-cone MTJ is more suitable for high-temperature operation.
Article
Computer Science, Information Systems
Zhilong Liu, Minggang Li, Zhifeng Zhu, Linhai Xiao, Changhua Nie, Zhangchun Tang
Summary: This paper proposes a method for identifying the health states of nuclear power main circulating pump based on ensemble empirical mode decomposition (EEMD) and support vector machine optimized by optimized quantum genetic algorithm (OQGA-SVM). The vibration signal of the main circulating pump is decomposed by EEMD to analyze the vibration signal characteristics in healthy and fault states and propose target characteristic indexes. Then, an OQGA-SVM model is established and the target characteristic indexes are used as input parameters. Experimental data analysis and validation show that the EEMD-OQGA-SVM method accurately and effectively identifies the health states of the main circulating pump, with higher accuracy and efficiency than the EEMD-SVM and EEMD-QGA-SVM methods.
Article
Materials Science, Multidisciplinary
Baofang Cai, Yihan He, Yue Xin, Zhengping Yuan, Xue Zhang, Zhifeng Zhu, Gengchiau Liang
Summary: The conventional computing method based on the von Neumann architecture faces challenges of high energy consumption and limited data exchange bandwidth. Neuromorphic computing and stochastic computing have emerged as promising alternatives due to their potential for energy-efficient and high-performance computing. Among the various unconventional computing technologies, MTJs have shown remarkable efficiency and similarity to biological nervous systems, making them a suitable candidate for implementing unconventional computing architectures.
APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
(2023)
Article
Materials Science, Textiles
Xun Zhang, Zhifeng Zhu, Jack Lin
Summary: Dimethylaminoethyl (DAE) starch was prepared by the tertiary amination of acid-converted maize starch (ACS) with 2-dimethylaminoethyl chloride hydrochloride (DAEC center dot HCl), and a series of DAE derivatives with different degrees of substitution (DS) were obtained. The amination significantly improved the bonding strength to polyester fibers and prevented difficulties in quaternized starch desizing. DAE starch showed competitive desizability during oxidant-alkali desizing. Thus, introduction of DAE groups onto ACS achieved a starch-based sizing material with strong bonding and good desizability, particularly with a DS value of 0.037-0.058 for potential application in polyester warp sizing.
FIBERS AND POLYMERS
(2023)
Article
Physics, Applied
Zhengping Yuan, Jingwei Long, Zhengde Xu, Yue Xin, Lihua An, Jie Ren, Xue Zhang, Yumeng Yang, Zhifeng Zhu
Summary: The dynamics of a spin torque-driven ferrimagnetic (FiM) system is investigated, demonstrating ultrafast switching in the picosecond range. Excessive current leads to magnetic oscillation, preventing unlimited increase in switching speed. The impact of thermal fluctuations is studied, distinguishing FiM dynamics into different regions. A significant deviation between FiM and ferromagnet (FM) is observed, with FM being insensitive to thermal fluctuations while the thermal effect is pronounced in FiM.
JOURNAL OF APPLIED PHYSICS
(2023)
Article
Physics, Condensed Matter
Weiyan Zhang, Tao Yu, Zhifeng Zhu, Binghan Li
Summary: The temperature characteristics of the read current of NOR embedded flash memory with a 1.5T-per-cell structure are analyzed and verified in this study. It is found that the read current of a programmed cell can increase, decrease, or remain unchanged with temperature, depending on the reading overdrive voltage or programming strength. By precisely controlling the programming strength and setting the reference cells to match the temperature coefficient of the tail data cells, the issue of current coefficient mismatch can be solved, leading to an improved read window.
JOURNAL OF SEMICONDUCTORS
(2023)
Article
Chemistry, Multidisciplinary
Xinran Wang, Hao Wu, Ruizhi Qiu, Xinhao Huang, Junrong Zhang, Jingwei Long, Yuxuan Yao, Yaru Zhao, Zhifeng Zhu, Junyong Wang, Shuyuan Shi, Haixin Chang, Weisheng Zhao
Summary: In this study, field-free switching at room temperature of the CoFeB/MgO heterostructure with perpendicular magnetic anisotropy is realized using large-scale, chemical vapor deposition (CVD)-grown, few-layer WTe2 thin films, thanks to unconventional spin-orbit torques (SOTs) in WTe2. Micro magnetic simulations are also used to investigate magnetization dynamics in the presence of out-of-plane polarized spin. This work paves the way for constructing all-electrical, low-power spintronic devices based on two-dimensional transition metal dichalcogenides (TMDs).
CELL REPORTS PHYSICAL SCIENCE
(2023)
Article
Physics, Applied
Zhengde Xu, Jie Ren, Zhengping Yuan, Yue Xin, Xue Zhang, Shuyuan Shi, Yumeng Yang, Zhifeng Zhu
Summary: In this paper, a trilayer AFM/insulator/heavy metal structure is proposed as the AFM memory device. The field-free switching of the AFM with a perpendicular Neel vector can be achieved by using two orthogonal currents. The device enables ultrafast switching within 40 ps and has reversibility.
JOURNAL OF APPLIED PHYSICS
(2023)
Article
Materials Science, Multidisciplinary
Xue Zhang, Baofang Cai, Jie Ren, Zhengping Yuan, Zhengde Xu, Yumeng Yang, Gengchiau Liang, Zhifeng Zhu
Summary: In this study, a two-dimensional atomistic model is developed and a torque analysis method is provided to study ferrimagnetic oscillation. By analyzing the spatial distribution of magnetization and effective fields, we demonstrate the presence and importance of spatially nonuniform oscillation phenomena. This research provides an important tool for gaining a deeper understanding of ferrimagnets and antiferromagnets.
Review
Oncology
Xinru Zhou, Yin Jia, Chuanbin Mao, Shanrong Liu
Summary: Small extracellular vesicles (sEVs), such as exosomes, have emerged as crucial targets for liquid biopsy and promising drug delivery vehicles in tumor progression. They can serve as biomarkers for tumor diagnosis and as drug carriers for cancer treatment.
Article
Oncology
Ruochan Chen, Ju Zhu, Xiao Zhong, Jie Li, Rui Kang, Daolin Tang
Summary: The interplay between autophagy and apoptosis plays a crucial role in tumorigenesis and cancer therapy, with HMGB1 serving as a key regulator in these processes.
Article
Oncology
Zongfu Pan, Xixuan Lu, Tong Xu, Jinming Chen, Lisha Bao, Ying Li, Yingying Gong, Yulu Che, Xiaozhou Zou, Zhuo Tan, Ping Huang, Minghua Ge
Summary: This study uncovered the emerging role of HN1 in promoting dedifferentiation of anaplastic thyroid cancer (ATC) cells. HN1 negatively regulated the thyroid differentiation markers and had an inhibitory effect on the transcriptional activation of CTCF, thereby influencing the chromatin accessibility of thyroid differentiation genes.
Article
Oncology
Yi Qin, Shengjun Xiong, Jun Ren, Gautam Sethi
Summary: Autophagy plays an important regulatory role in glioblastoma, and its dysregulation can lead to drug resistance and radioresistance. It also affects stem cell characteristics, overall growth, and metastasis. Therefore, autophagy is a promising target for glioblastoma therapy.
Article
Oncology
Katsuya Nagaoka, Xuewei Bai, Dan Liu, Kevin Cao, Joud Mulla, Chengcheng Ji, Hongze Chen, Muhammad Azhar Nisar, Amalia Bay, William Mueller, Grace Hildebrand, Jin-Song Gao, Shaolei Lu, Hiroko Setoyama, Yasuhito Tanaka, Jack R. Wands, Chiung-Kuei Huang
Summary: This study found that serum 2-OG levels in cholangiocarcinoma patients are associated with the effectiveness of chemotherapy. Patients with progressive disease showed significantly higher levels of serum 2-OG compared to stable disease and partial response patients. The study also revealed that overexpression of ASPH mimics the effects of 2-OG, and knockdown of ASPH improves chemotherapy. Targeting ASPH enhances the effects of chemotherapy by modulating ATM and ATR, two key regulators of DDRs.
