期刊
CANCER LETTERS
卷 266, 期 1, 页码 12-20出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2008.02.028
关键词
HIF-1 signalling; reactive oxygen species; cancer; ERK/MEK; PI3K; PKB/Akt; mTOR; protein hydroxylation
类别
The heterodimeric transcription factor HIF-1 (hypoxia-inducible factor 1) represents the key mediator of hypoxia response. HIF-1 controls numerous genes of pivotal importance for cellular metabolism, angiogenesis, cell cycle regulation and inhibition of apoptosis. HIF-1 overexpression and enhanced transcriptional activity are linked to tumour initiation and progression. Malfunction of the HIF-1 signalling network has been associated with breast, ovarian and prostate cancers. Elevated reactive oxygen species (ROS), also observed in such tumours, have been implicated in HIF-1 signalling. Deciphering the role of ROS in cancer onset and their involvement in signalling networks should prove invaluable for the design of novel anticancer therapeutics. (c) 2008 Elsevier Ireland Ltd. All rights reserved.
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