期刊
CANCER JOURNAL
卷 16, 期 4, 页码 325-335出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/PPO.0b013e3181eb33bc
关键词
chemokines; chemokine receptors; antitumor immunity; immunotherapy; gene therapy; cancer vaccines; dendritic cells; infiltrating T cells
类别
资金
- NCI/NIH
- V Foundation
- Bankhead-Coley Cancer Research Program
- Department of Veterans Affairs
- University of California
Chemokines (ie, chemoattractant cytokines) are a family of small secreted molecules that mediate leukocyte migration. It is becoming increasingly more evident that chemokines play an integral role in the initiation of a specific immune response. With respect to cancer, chemokines are being studied for both their role in tumor biology and as promising immunotherapy candidates. We review several areas of chemokine importance in tumor immunity and discuss the experimental evidence that is leading to the clinical use of this cytokine family in new treatment approaches for patients with cancer.
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